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VESSEL CO-COPTION SIGNED

Vessel co-option and radioresistance in glioblastoma

Total Cost €

0

EC-Contrib. €

0

Partnership

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 VESSEL CO-COPTION project word cloud

Explore the words cloud of the VESSEL CO-COPTION project. It provides you a very rough idea of what is the project "VESSEL CO-COPTION" about.

resistance    cancer    co    migration    insights    removed    tumor    highlights    multipotent    fraction    option    treatment    radiotherapy    models    deadliest    stem    multiphoton    patients    mechanistically    90    cellular    types    uncover    involvement    aggressive    chemotherapy    spreading    organotypic    confers    cultures    benefit    impacts    perivascular    radiosensitize    initiating    dynamics    understand    underlying    orthotopic    multiple    molecular    intravital    niche    mostly    vessels    resection    gscs    therapy    receive    gsc    connections    progression    regime    glioblastoma    renewing    interaction    efficacy    space    self    human    attributed    therapeutic    recurrence    gbm    regrowth    glioma    radioresistance    vascular    radiation    clinically    directional    caused    cells    bulk    mechanism    invasive    rate    strategies    hypothesis    differentiated    screenings    survival    despite    vessel    exact    microscopy    unknown    brain   

Project "VESSEL CO-COPTION" data sheet

The following table provides information about the project.

Coordinator
INSTITUT CURIE 

Organization address
address: rue d'Ulm 26
city: PARIS
postcode: 75231
website: www.curie.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 1˙499˙823 €
 EC max contribution 1˙499˙823 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-08-01   to  2024-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT CURIE FR (PARIS) coordinator 1˙499˙823.00

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 Project objective

Glioblastoma (GBM) is one of the deadliest types of human cancer. Despite a very aggressive treatment regime – including resection of the tumor, radiation and chemotherapy – its estimated recurrence rate is more than 90%. Recurrence is mostly caused by the regrowth of highly invasive cells spreading from the tumor bulk, which are not removed by resection. To develop an effective therapeutic approach, we need to better understand the underlying molecular mechanism of radiation resistance and tumor spreading in GBM. Radioresistance in GBM is attributed to glioma stem cells (GSCs), a fraction of perivascular, self-renewing, multipotent and tumor-initiating cells. Growing evidence highlights the perivascular space as a niche for GSC survival, resistance to therapy, progression and dissemination. The unknown factor is the dynamics of GSCs, how they end up in the vascular niche and how this impacts on radioresistance. My overall hypothesis is that GSCs reach the perivascular niche through vessel co-option - the directional migration of tumor cells towards vessels - and that targeting vessel co-option has the potential to radiosensitize GBM. With this project, we aim to uncover the exact molecular and cellular connections among vessel co-option, GSCs, the vascular niche and radioresistance. Using multiple strategies, such as multiphoton intravital microscopy, orthotopic models of GBM, organotypic cultures, screenings and survival studies, we will investigate and mechanistically change the dynamics of GSC and differentiated GBM cells in order to understand the role of their interaction with brain vessels and whether this confers resistance to radiotherapy. These studies will provide clinically relevant insights into the involvement of GSCs, the vascular niche and vessel co-option in the resistance of GBM to therapy. Since all GBM patients receive radiotherapy, many would benefit from therapeutic strategies aimed at increasing its efficacy.

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The information about "VESSEL CO-COPTION" are provided by the European Opendata Portal: CORDIS opendata.

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