Opendata, web and dolomites
  1. home
  2. trasparenza
  3. open h2020
  4. esx-4 t7ss

ESX-4 T7SS SIGNED

Structure/function of a prototypic type VII secretion system from a fast-growing pathogenic mycobacteria

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 ESX-4 T7SS project word cloud

Explore the words cloud of the ESX-4 T7SS project. It provides you a very rough idea of what is the project "ESX-4 T7SS" about.

aring    slow    except    investigation    mechanism    attractive    integrative    mycobacteria    substrate    membrane    recognition    responsible    modeling    survive    microbiology    crosses    deemed    mtb    inactive    t7ss    intact    characterization    secretion    functional    multiply    questions    13    extrapulmonary    mycp    communities    published    pulmonary    tuberculous    active    shown    resolution    mediated    sgm    inner    complementary    genetics    date    abscessus    diverse    rendering    resistant    eccc    ecce    protein    survival    virulence    opportunistic    host    lab    cell    acquired    experiments    ecce4    holo    function    mycobacterium    infection    collaborators    infections    data    esx    multiple    structure    dalton    combine    substrates    lack    mab    possess    central    clinically    biology    intracellular    ancestral    eccb    unlike    form    esx4    awaited    experimental    macrophages    rgm    interdisciplinary    structural    eccd    components    tuberculosis    multidrug    eagerly    functionally   

Project "ESX-4 T7SS" data sheet

The following table provides information about the project.

Coordinator		 EUROPEAN MOLECULAR BIOLOGY LABORATORY 

Organization address
address: Meyerhofstrasse 1
city: HEIDELBERG
postcode: 69117
website: http://www.embl.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country Germany [DE]
 Total cost 162˙806 €
 EC max contribution 162˙806 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-04-01   to  2021-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    EUROPEAN MOLECULAR BIOLOGY LABORATORY DE (HEIDELBERG) coordinator 162˙806.00

Map

 Project objective

Mycobacterium abscessus (Mab) is an opportunistic-multidrug-resistant non-tuberculous mycobacteria responsible for multiple clinically-acquired infections both pulmonary and extrapulmonary. Unlike many rapidly growing mycobacteria (RGM), Mab is able to survive and multiply within macrophages, similar to slow growing mycobacteria (SGM) such as M. tuberculosis (Mtb). In Mtb, five T7SS (ESX-1-5) have been identified and shown to be essential for intracellular survival (ESX-1), virulence (ESX-1 and ESX-5) or growth (ESX-3). T7SS are composed of five protein components essential for function: EccB, EccC, EccD, EccE and MycP. Except for a low-resolution structure of the holo ESX-5 complex from the host lab at 13 Å resolution, no structural data on any T7SS have been published to date, rendering structural work timely and eagerly awaited by relevant communities. Deemed inactive due to its lack of one of the established T7SS components EccE4, ESX-4 has been considered an ancestral T7SS form. However, Mab possess a fully intact and functional ESX-4, essential for its intracellular survival, rendering it a highly attractive target for an in-depth characterization. Here, I propose an interdisciplinary project that includes both functional and structural investigation. As the 2 M Dalton-holo-complex crosses the Mab inner membrane, experimental structural work will be challenging and require an integrative modeling approach to combine diverse experimental data sets. Complementary infection biology experiments including microbiology, genetics and cell biology will be carried out by collaborators. With this work, I aim to respond to central questions related to T7SS in general and Mab ESX-4 specifically, such as: what is the mechanism of T7SS-mediated secretion? What makes ESX-4 specific and different from other T7SS? What is the specific role of EccE4 to establish a functionally active ESX4? and What are the substrates and specific mechanism of ESX-4 substrate recognition?

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "ESX-4 T7SS" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "ESX-4 T7SS" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

NSTree (2020)

Understanding substrate delivery for cell wall biosynthesis in plants

Read More  

MetEpiC (2020)

P53-dependent Metabolic and Epigenetic Reprogramming in Carcinogenesis

Read More  

RipGEESE (2020)

Identifying the ripples of gene regulation evolution in the evolution of gene sequences to determine when animal nervous systems evolved

Read More