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TOX-ANT SIGNED

Toxin-antidote selfish elements in animals: from gene drive to speciation

Total Cost €

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EC-Contrib. €

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Partnership

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 TOX-ANT project word cloud

Explore the words cloud of the TOX-ANT project. It provides you a very rough idea of what is the project "TOX-ANT" about.

biochemistry    sup    surprisingly    multidisciplinary    laws    vertebrates    pha    animals    close    global    mechanism    toxin    diverse    anticipated    medicine    genetics    gene    idea    raises    predict    critical    time    health    unknown    prevalence    mosquito    synthetic    acting    spread    lack    team    speciation    genomics    virus    mapping    stimulate    tropicalis    biology    questions    drive    screen    suggests    perpetuated    nematode    paternal    antagonize    antidote    nematodes    class    discovered    species    selfish    bulk    leveraging    extremely    examples    underlying    animal    35    expertise    evolutionary    segregation    evo    dissected    medaka    vectors    populations    rare    ta    diseases    elegans    largely    effect    mimicking    fitness    adults    genetically    natural    mendelian    qtl    subverting    molecular    relative    action    balancing    efficient    first    origin    zika    devo    view    fish    decade    burdens    malaria    contribution    challenged    discover    mechanisms    spreading    dissecting    dissect    previously   

Project "TOX-ANT" data sheet

The following table provides information about the project.

Coordinator
INSTITUT FUER MOLEKULARE BIOTECHNOLOGIE GMBH 

Organization address
address: DR BOHRGASSE 3
city: WIEN
postcode: 1030
website: www.imba.oeaw.ac.at

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Austria [AT]
 Total cost 1˙498˙428 €
 EC max contribution 1˙498˙428 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-STG
 Funding Scheme ERC-STG
 Starting year 2020
 Duration (year-month-day) from 2020-03-01   to  2025-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT FUER MOLEKULARE BIOTECHNOLOGIE GMBH AT (WIEN) coordinator 1˙498˙428.00

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 Project objective

Toxin-antidote (TA) elements are a class of selfish elements that spread in natural populations by subverting the laws of Mendelian segregation (gene drive activity). For a decade, the only known TA element in animals was a paternal-acting element discovered in the nematode C. elegans. The lack of other examples perpetuated the idea that TA elements were extremely rare in animals. However, I recently challenged this view with two key findings 1) I genetically dissected a second TA element in C. elegans, the element sup-35/pha-1, and 2) I identified five novel TA elements in C. tropicalis, a close relative of C. elegans. Surprisingly, some of these novel TA elements can affect the fitness of adults and can antagonize each other mimicking the effect of balancing selection. Overall, my research strongly suggests that TA elements are much more common in animals than previously anticipated and raises critical questions about their origin, prevalence, mechanism of action, and contribution to speciation, all of which are largely unknown. This proposal has three main objectives: 1. To dissect the molecular mechanisms underlying an animal TA element for the first time. 2. To identify and characterize novel TA elements in diverse nematode species. 3. To screen for TA elements in medaka fish. My team and I will achieve these objectives by leveraging my multidisciplinary expertise in genomics, evo-devo, and biochemistry, as well as a state-of-the-art bulk QTL mapping method that I recently developed. Dissecting the molecular mechanisms used by natural selfish elements will help us design more efficient and specific synthetic drive elements that could target mosquito vectors spreading diseases such as malaria and Zika virus - global health burdens. I predict that we will discover and characterize many novel TA selfish elements in diverse species from nematodes to vertebrates. Our findings will stimulate new research areas in genetics, evolutionary biology, and medicine.

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