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TOX-ANT SIGNED

Toxin-antidote selfish elements in animals: from gene drive to speciation

Total Cost €

0

EC-Contrib. €

0

Partnership

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 TOX-ANT project word cloud

Explore the words cloud of the TOX-ANT project. It provides you a very rough idea of what is the project "TOX-ANT" about.

subverting    perpetuated    critical    dissect    mapping    anticipated    antidote    biology    vectors    drive    malaria    predict    mechanisms    medicine    mimicking    view    team    sup    adults    mechanism    synthetic    virus    stimulate    diverse    raises    gene    devo    antagonize    bulk    relative    leveraging    tropicalis    genetically    medaka    vertebrates    paternal    evolutionary    class    idea    spread    dissecting    contribution    toxin    species    discover    balancing    screen    populations    origin    laws    underlying    examples    global    mosquito    35    nematode    efficient    fitness    diseases    discovered    multidisciplinary    effect    genomics    natural    challenged    time    selfish    surprisingly    dissected    spreading    unknown    prevalence    animal    burdens    extremely    first    health    rare    segregation    questions    molecular    nematodes    close    biochemistry    mendelian    qtl    lack    fish    zika    speciation    evo    elegans    largely    expertise    ta    action    genetics    acting    decade    suggests    previously    pha    animals   

Project "TOX-ANT" data sheet

The following table provides information about the project.

Coordinator
INSTITUT FUER MOLEKULARE BIOTECHNOLOGIE GMBH 

Organization address
address: DR BOHRGASSE 3
city: WIEN
postcode: 1030
website: www.imba.oeaw.ac.at

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Austria [AT]
 Total cost 1˙498˙428 €
 EC max contribution 1˙498˙428 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-STG
 Funding Scheme ERC-STG
 Starting year 2020
 Duration (year-month-day) from 2020-03-01   to  2025-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT FUER MOLEKULARE BIOTECHNOLOGIE GMBH AT (WIEN) coordinator 1˙498˙428.00

Map

 Project objective

Toxin-antidote (TA) elements are a class of selfish elements that spread in natural populations by subverting the laws of Mendelian segregation (gene drive activity). For a decade, the only known TA element in animals was a paternal-acting element discovered in the nematode C. elegans. The lack of other examples perpetuated the idea that TA elements were extremely rare in animals. However, I recently challenged this view with two key findings 1) I genetically dissected a second TA element in C. elegans, the element sup-35/pha-1, and 2) I identified five novel TA elements in C. tropicalis, a close relative of C. elegans. Surprisingly, some of these novel TA elements can affect the fitness of adults and can antagonize each other mimicking the effect of balancing selection. Overall, my research strongly suggests that TA elements are much more common in animals than previously anticipated and raises critical questions about their origin, prevalence, mechanism of action, and contribution to speciation, all of which are largely unknown. This proposal has three main objectives: 1. To dissect the molecular mechanisms underlying an animal TA element for the first time. 2. To identify and characterize novel TA elements in diverse nematode species. 3. To screen for TA elements in medaka fish. My team and I will achieve these objectives by leveraging my multidisciplinary expertise in genomics, evo-devo, and biochemistry, as well as a state-of-the-art bulk QTL mapping method that I recently developed. Dissecting the molecular mechanisms used by natural selfish elements will help us design more efficient and specific synthetic drive elements that could target mosquito vectors spreading diseases such as malaria and Zika virus - global health burdens. I predict that we will discover and characterize many novel TA selfish elements in diverse species from nematodes to vertebrates. Our findings will stimulate new research areas in genetics, evolutionary biology, and medicine.

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The information about "TOX-ANT" are provided by the European Opendata Portal: CORDIS opendata.

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