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TOX-ANT SIGNED

Toxin-antidote selfish elements in animals: from gene drive to speciation

Total Cost €

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EC-Contrib. €

0

Partnership

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 TOX-ANT project word cloud

Explore the words cloud of the TOX-ANT project. It provides you a very rough idea of what is the project "TOX-ANT" about.

raises    animal    selfish    stimulate    genetics    medicine    natural    leveraging    relative    effect    evolutionary    qtl    expertise    synthetic    mendelian    examples    antidote    medaka    largely    nematodes    tropicalis    extremely    nematode    spread    acting    critical    drive    malaria    screen    evo    populations    mechanisms    dissected    underlying    origin    adults    unknown    class    health    devo    diseases    team    ta    time    first    fish    action    idea    discover    35    laws    previously    discovered    toxin    anticipated    biology    dissecting    mapping    global    paternal    decade    vertebrates    gene    view    fitness    virus    lack    efficient    prevalence    genetically    sup    spreading    zika    bulk    antagonize    multidisciplinary    molecular    mosquito    burdens    dissect    close    pha    balancing    elegans    questions    vectors    biochemistry    predict    speciation    rare    mechanism    subverting    challenged    genomics    contribution    suggests    species    segregation    mimicking    surprisingly    diverse    animals    perpetuated   

Project "TOX-ANT" data sheet

The following table provides information about the project.

Coordinator
INSTITUT FUER MOLEKULARE BIOTECHNOLOGIE GMBH 

Organization address
address: DR BOHRGASSE 3
city: WIEN
postcode: 1030
website: www.imba.oeaw.ac.at

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Austria [AT]
 Total cost 1˙498˙428 €
 EC max contribution 1˙498˙428 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-STG
 Funding Scheme ERC-STG
 Starting year 2020
 Duration (year-month-day) from 2020-03-01   to  2025-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT FUER MOLEKULARE BIOTECHNOLOGIE GMBH AT (WIEN) coordinator 1˙498˙428.00

Map

 Project objective

Toxin-antidote (TA) elements are a class of selfish elements that spread in natural populations by subverting the laws of Mendelian segregation (gene drive activity). For a decade, the only known TA element in animals was a paternal-acting element discovered in the nematode C. elegans. The lack of other examples perpetuated the idea that TA elements were extremely rare in animals. However, I recently challenged this view with two key findings 1) I genetically dissected a second TA element in C. elegans, the element sup-35/pha-1, and 2) I identified five novel TA elements in C. tropicalis, a close relative of C. elegans. Surprisingly, some of these novel TA elements can affect the fitness of adults and can antagonize each other mimicking the effect of balancing selection. Overall, my research strongly suggests that TA elements are much more common in animals than previously anticipated and raises critical questions about their origin, prevalence, mechanism of action, and contribution to speciation, all of which are largely unknown. This proposal has three main objectives: 1. To dissect the molecular mechanisms underlying an animal TA element for the first time. 2. To identify and characterize novel TA elements in diverse nematode species. 3. To screen for TA elements in medaka fish. My team and I will achieve these objectives by leveraging my multidisciplinary expertise in genomics, evo-devo, and biochemistry, as well as a state-of-the-art bulk QTL mapping method that I recently developed. Dissecting the molecular mechanisms used by natural selfish elements will help us design more efficient and specific synthetic drive elements that could target mosquito vectors spreading diseases such as malaria and Zika virus - global health burdens. I predict that we will discover and characterize many novel TA selfish elements in diverse species from nematodes to vertebrates. Our findings will stimulate new research areas in genetics, evolutionary biology, and medicine.

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The information about "TOX-ANT" are provided by the European Opendata Portal: CORDIS opendata.

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