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MUSMICRO SIGNED

Causes and consequences of variation in the mammalian microbiota

Total Cost €

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EC-Contrib. €

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Partnership

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Project "MUSMICRO" data sheet

The following table provides information about the project.

Coordinator
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD 

Organization address
address: WELLINGTON SQUARE UNIVERSITY OFFICES
city: OXFORD
postcode: OX1 2JD
website: www.ox.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 1˙771˙166 €
 EC max contribution 1˙771˙166 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-STG
 Funding Scheme ERC-STG
 Starting year 2020
 Duration (year-month-day) from 2020-02-01   to  2025-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD UK (OXFORD) coordinator 1˙771˙166.00

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 Project objective

The mammalian gut teems with a particularly dense and diverse microbial community, the composition of which varies widely among hosts. A large body of laboratory work suggests these communities provide important functions for the host – including nutrition, pathogen protection and immune development – but we know very little about what shapes the mammalian gut microbiota, and how it affects the host, in natural populations. A major barrier to progress is a lack of powerful investigative tools for most wild animal species. I will overcome this by studying a natural population of the species that has the best laboratory tools, and knowledge, for the mammalian microbiome: the house mouse. Specifically, I will set up a new wild house mouse system and use it to address three broad questions: 1) what drives natural variation in the gut microbiota? 2) does microbiota variation predict fitness traits in the wild? and, critically, 3) does microbiota variation causally affect fitness-relevant traits? To do this, I will pair detailed, longitudinal studies of wild mice with controlled experiments in the lab, making use of state-of-the-art tools for this species, including: (i) faecal transplant experiments with germ-free animals, to test the phenotypic impact of different wild mouse microbiotas (ii) high resolution genotyping methods and (iii) new radio-frequency identification (RFID) technology we have recently developed for monitoring wild rodent survival and behaviour. By doing so, this project will directly tackle the key unanswered question: does the composition of the mammalian gut microbiota actually matter in nature?

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The information about "MUSMICRO" are provided by the European Opendata Portal: CORDIS opendata.

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