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ImmunoSep SIGNED

Personalized immunotherapy in sepsis: a precision medicine based approach

Total Cost €

EC-Contrib. €

Partnership

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ImmunoSep project word cloud

Explore the words cloud of the ImmunoSep project. It provides you a very rough idea of what is the project "ImmunoSep" about.

metabolome medicine sepsis mortality infections health 180 chart pathophysiology host intensive status biology individual enrolled dysfunction immunotherapy caused trial personalized platform generation antibiotics threatening data dysregulated psychological trials epigenome course proof life immunoparalysis decreased 40 integrate outcome overinflammation precision answer hope least significantly units biomarkers theranostics heterogeneity introducing transcriptome immunotherapeutic building revolutionized mission patients strategies usefulness endotypes multidimensional infection perform patient countries bridges complementary materialize immunotherapies datasets omics pursued clinical organ therapeutic treatment care community incompletely revolution genome hoped microbiome time did immune employed

Project "ImmunoSep" data sheet

The following table provides information about the project.

Coordinator	STICHTING KATHOLIEKE UNIVERSITEIT Organization address address: GEERT GROOTEPLEIN NOORD 9 city: NIJMEGEN postcode: 6525 EZ website: www.radboudumc.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Netherlands [NL]
Total cost	10˙081˙333 €
EC max contribution	10˙081˙333 € (100%)
Programme	1. H2020-EU.3.1.3. (Treating and managing disease)
Code Call	H2020-SC1-2019-Two-Stage-RTD
Funding Scheme	RIA
Starting year	2020
Duration (year-month-day)	from 2020-01-01 to 2023-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	STICHTING KATHOLIEKE UNIVERSITEIT STICHTING KATHOLIEKE UNIVERSITEIT Organization address address: GEERT GROOTEPLEIN NOORD 9 city: NIJMEGEN postcode: 6525 EZ website: www.radboudumc.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (NIJMEGEN)	coordinator	1˙660˙226.00
2	ELLINIKO INSTITUTO MELETIS TIS SIPSIS ELLINIKO INSTITUTO MELETIS TIS SIPSIS Organization address address: Michalakopoulou 88 city: ATHENS postcode: 11528 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	EL (ATHENS)	participant	1˙700˙000.00
3	ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM Organization address address: MEIBERGDREEF 15 city: AMSTERDAM postcode: 1105AZ website: www.amc.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (AMSTERDAM)	participant	950˙000.00
4	HOSPICES CIVILS DE LYON HOSPICES CIVILS DE LYON Organization address address: QUAI DES CELESTINS 3 city: LYON postcode: 69002 website: www.chu-lyon.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (LYON)	participant	760˙080.00
5	CENTRE HOSPITALIER UNIVERSITAIRE VAUDOIS CENTRE HOSPITALIER UNIVERSITAIRE VAUDOIS Organization address address: RUE DU BUGNON 21 city: LAUSANNE postcode: 1011 website: www.chuv.ch contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (LAUSANNE)	participant	760˙000.00
6	Universitätsklinikum Jena Universitätsklinikum Jena Organization address address: Bachstraße 18 city: Jena postcode: 7743 website: www.uniklinikum-jena.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (Jena)	participant	759˙875.00
7	RHEINISCHE FRIEDRICH-WILHELMS-UNIVERSITAT BONN RHEINISCHE FRIEDRICH-WILHELMS-UNIVERSITAT BONN Organization address address: REGINA PACIS WEG 3 city: BONN postcode: 53113 website: www.uni-bonn.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (BONN)	participant	505˙881.00
8	CEMM - FORSCHUNGSZENTRUM FUER MOLEKULARE MEDIZIN GMBH CEMM - FORSCHUNGSZENTRUM FUER MOLEKULARE MEDIZIN GMBH Organization address address: LAZARETTGASSE 14 AKH BT 25.3 city: WIEN postcode: 1090 website: http://www.oeaw.ac.at/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	AT (WIEN)	participant	499˙715.00
9	UNIVERSITATEA DE MEDICINA SI FARMACIE IULIU HATIEGANU CLUJ-NAPOCA UNIVERSITATEA DE MEDICINA SI FARMACIE IULIU HATIEGANU CLUJ-NAPOCA Organization address address: VICTOR BABES STREET 8 city: Cluj-Napoca postcode: 400012 website: www.umfcluj.ro contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	RO (Cluj-Napoca)	participant	460˙001.00
10	BIOASTER FONDATION DE COOPERATION SCIENTIFIQUE BIOASTER FONDATION DE COOPERATION SCIENTIFIQUE Organization address address: 40 AVENUE TONY GARNIER city: LYON postcode: 69007 website: www.bioaster.org contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (LYON)	participant	436˙270.00
11	EURICE EUROPEAN RESEARCH AND PROJECT OFFICE GMBH EURICE EUROPEAN RESEARCH AND PROJECT OFFICE GMBH Organization address address: HEINRICH-HERTZ-ALLEE 1 city: ST INGBERT postcode: 66386 website: www.eurice.eu contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (ST INGBERT)	participant	402˙625.00
12	TEL AVIV UNIVERSITY TEL AVIV UNIVERSITY Organization address address: RAMAT AVIV city: TEL AVIV postcode: 69978 website: http://www.tau.ac.il/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IL (TEL AVIV)	participant	399˙975.00
13	BIOMERIEUX SA BIOMERIEUX SA Organization address address: Chemin de l'Orme city: Marcy l'Etoile postcode: 69280 website: www.biomerieux.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (Marcy l'Etoile)	participant	399˙685.00
14	THE UNIVERSITY OF READING THE UNIVERSITY OF READING Organization address address: WHITEKNIGHTS CAMPUS WHITEKNIGHTS HOUSE city: READING postcode: RG6 6AH website: http://www.rdg.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (READING)	participant	387˙000.00

Map

Project objective

Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection, and is characterized by a high mortality of up to 30-40%. Treatment of sepsis was revolutionized by two steps that significantly decreased mortality: antibiotics and the intensive care units. It has been hoped that a third revolution, immunotherapy, would further improve outcome of sepsis, but this hope did not materialize. This was due to the incompletely understood pathophysiology, and the heterogeneity of the immune status in different sepsis patients. We propose that while both overinflammation and immunoparalysis are important, they are present in individual sepsis patients.The mission of the present project is to design and perform a proof-of-concept clinical trial of personalized immunotherapy in sepsis, and within this clinical trial, to develop a next-generation theranostics platform for the design of future personalized immunotherapy trials in sepsis. This theranostics platform would be based on an integrated, multidimensional systems biology analysis of omics-based datasets, to identify biomarkers, clinical endotypes, and therapeutic targets for precision medicine approaches. In order to achieve the mission proposed, several complementary aims will be pursued: Aim 1: To design and perform a large personalized immunotherapy trial in sepsis patients, that can provide a clinical answer towards the usefulness of currently employed immunotherapies for sepsis. Aim 2: To chart host genome, epigenome, transcriptome, metabolome and microbiome in at least 180 sepsis patients enrolled in Aim 1 over a defined time course. Aim 3: To use a theranostics approach based on the data provided by Aim 2 to design novel personalized immunotherapeutic strategies. Aim 4: To integrate the clinical and psychological aspects involved when introducing novel immunotherapies for infections in the health care systems of European countries, building bridges with the patient community.

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The information about "IMMUNOSEP" are provided by the European Opendata Portal: CORDIS opendata.