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SENATOR TERMINATED
Staff Exchange for Novel applications in 19f magnetic resonance imaging
Total Cost €
0EC-Contrib. €
0Partnership
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0SENATOR project word cloud
Explore the words cloud of the SENATOR project. It provides you a very rough idea of what is the project "SENATOR" about.
materials
generally
risk
animals
biomaterial
historically
deemed
novelty
cell
safe
professionals
background
signal
kidneys
basis
absolutely
expansion
impairment
preclinical
discrimination
door
repeated
regarding
gbca
molecular
move
surrounding
gbcas
tissues
imaged
clinical
multifunctional
mri
active
visualised
2015
found
resolution
agents
therapeutic
tissue
until
cells
ligands
quantitative
technique
safety
healthcare
renal
modality
spurred
whilst
area
migration
smart
released
competing
deposits
fda
insights
patients
opened
gadolinium
resonance
diagnostic
nanoparticles
limit
accumulated
inside
generation
functionalisation
tolerated
signatures
payload
labelled
magnetic
announcement
advised
accumulate
invasive
incorporated
mounting
trafficking
situations
bone
body
perfluorocarbon
imaging
living
biology
individual
structures
19f
contrast
reagents
brain
administered
Project "SENATOR" data sheet
The following table provides information about the project.
| Coordinator |
INSTITUTO DE MEDICINA MOLECULAR JOAO LOBO ANTUNES
Organization address contact info |
| Coordinator Country | Portugal [PT] |
| Total cost | 1˙541˙000 € |
| EC max contribution | 1˙541˙000 € (100%) |
| Programme |
1. H2020-EU.1.3.3. (Stimulating innovation by means of cross-fertilisation of knowledge) |
| Code Call | H2020-MSCA-RISE-2019 |
| Funding Scheme | MSCA-RISE |
| Starting year | 2020 |
| Duration (year-month-day) | from 2020-05-01 to 2024-04-30 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | INSTITUTO DE MEDICINA MOLECULAR JOAO LOBO ANTUNES | PT (LISBOA) | coordinator | 234˙600.00 |
| 2 | PERCUROS BV | NL (LEIDEN) | participant | 202˙400.00 |
| 3 | ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM | NL (ROTTERDAM) | participant | 165˙600.00 |
| 4 | UNIVERSITA DEGLI STUDI DI CAMERINO | IT (CAMERINO) | participant | 161˙000.00 |
| 5 | TECOBIOSCIENCES GMBH | DE (LANDSHUT) | participant | 156˙400.00 |
| 6 | UNIVERSITA DEGLI STUDI DI NAPOLI FEDERICO II | IT (NAPOLI) | participant | 156˙400.00 |
| 7 | MEDRES-MEDICAL RESEARCH GMBH | DE (KOLN) | participant | 147˙200.00 |
| 8 | HEINRICH-HEINE-UNIVERSITAET DUESSELDORF | DE (DUSSELDORF) | participant | 110˙400.00 |
| 9 | GOOD BIOMARKER SCIENCES BV | NL (SASSENHEIM) | participant | 82˙800.00 |
| 10 | PROGREDUM GMBH | DE (KAISERSLAUTERN) | participant | 82˙800.00 |
| 11 | ACADEMISCH ZIEKENHUIS LEIDEN | NL (LEIDEN) | participant | 41˙400.00 |
Map
Project objective
Magnetic resonance imaging (MRI) is a leading clinical diagnostic technique, which is able to provide whole body imaging, and when individual cells are imaged in living animals, it can provide new insights into the biology of cell trafficking and migration. For cells to be visualised by MRI, they generally must be labelled to enable their discrimination from surrounding tissue. The development of magnetic resonance imaging (MRI) contrast agents is therefore an active area of research, where the basis for this interest is the expansion of MRI as a high-resolution and non-invasive important preclinical and clinical imaging modality. Moreover, there are now new opportunities to developing smart materials with multifunctional abilities including MRI contrast in-built within biomaterial structures, functionalisation with targeting ligands and the carrying of a therapeutic payload. This move towards a new generation of MRI contrast reagents has also been spurred on by the mounting evidence against gadolinium-based contrast agents (GBCAs). They are currently the agents of choice and were considered historically safe and well tolerated until recently. However, they have been found to accumulate in various tissues of patients who do not have renal impairment, including bone, brain and kidneys. Furthermore, in 2015, the FDA released a new safety announcement regarding GBCAs and the risk of accumulated deposits in the brain following repeated use. Whilst GBCAs are being investigated, they can still be administered but healthcare professionals have been advised to limit the use of GBCA to situations in which contrast is deemed absolutely necessary.This has opened the door to the novelty of using perfluorocarbon (19F) being incorporated inside smart nanoparticles, which can offer unique quantitative signatures for molecular MRI with no competing background signal.
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The information about "SENATOR" are provided by the European Opendata Portal: CORDIS opendata.
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lastchecktime (2024-05-12 8:43:35) correctly updated