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THERA SIGNED
Therapeutic Drug Monitoring with Smartphone-integrated Surface Enhanced Raman Spectroscopy
Total Cost €
0EC-Contrib. €
0Partnership
0Views
0THERA project word cloud
Explore the words cloud of the THERA project. It provides you a very rough idea of what is the project "THERA" about.
weight
alternative
reactions
verified
barriers
tdm
miniaturized
sized
output
shown
analyte
proposition
device
minimum
ms
therapeutic
spectroscopy
experimentally
routine
chromatography
mass
exclusively
prevent
validate
molecules
hospitals
lc
single
clinical
droplet
tabletop
narrow
transform
first
samples
spectrometry
smartphone
enhanced
measuring
variety
liquid
circulating
maximise
mu
concentration
intervals
pure
patients
toxicity
drugs
efficacy
sers
surface
artificial
readiness
analytes
hplc
adverse
utility
friendliness
minutes
complexity
perform
central
de
blood
designated
thera
elisa
specialized
immunoassays
commercial
monitoring
consistent
feasibility
limit
technologies
adaptability
performance
business
maintenance
laboratories
tool
throughput
fraction
drug
raman
detection
data
commercially
plasma
size
Project "THERA" data sheet
The following table provides information about the project.
| Coordinator |
DANMARKS TEKNISKE UNIVERSITET
Organization address contact info |
| Coordinator Country | Denmark [DK] |
| Total cost | 0 € |
| EC max contribution | 150˙000 € (0%) |
| Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
| Code Call | ERC-2019-PoC |
| Funding Scheme | ERC-POC-LS |
| Starting year | 2020 |
| Duration (year-month-day) | from 2020-02-01 to 2021-07-31 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | DANMARKS TEKNISKE UNIVERSITET | DK (KGS LYNGBY) | coordinator | 150˙000.00 |
Map
Project objective
Therapeutic drug monitoring (TDM) is an essential tool for measuring the circulating concentration of specific narrow therapeutic drugs at designated intervals, in order to maximise the efficacy of the drug and avoid toxicity and adverse drug reactions. TDM is currently available only in central laboratories or large hospitals, and several barriers prevent its wide implementation in routine clinical practice. First, current technologies used for TDM (e.g. high-performance liquid chromatography – HPLC, mass spectrometry – MS) are exclusively used in central laboratories due to their cost, system size and weight, complexity of use and maintenance requirements. Second, alternative technologies (e.g. ELISA immunoassays) are analyte-specific and do not allow adaptability to new analytes (increasing costs). We verified the feasibility and clinical utility of using Surface Enhanced Raman Spectroscopy (SERS) for TDM using real plasma samples taken from de-identified patients. Importantly, our measurements were consistent with state-of-the-art data generated by LC-MS/MS. We already have experimentally shown a 0.1 μM detection limit on pure, artificial samples. Within THERA, we aim to transform our research output into a commercially-relevant (in terms of size, throughput, user friendliness and cost) product by creating a minimum viable product that will enable TDM for a wide variety of molecules. Our goal within this project is to validate this device on clinical samples and build a strong business case for it that will enable commercial exploitation. THERA will advance our SERS-based device from a current technology readiness level of 3 to 5/6. Our value proposition is a tabletop, miniaturized (smartphone-sized) device that can perform TDM on a single droplet of blood, in a matter of minutes, without the need for specialized personnel, at a fraction of the cost currently associated with TDM.
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The information about "THERA" are provided by the European Opendata Portal: CORDIS opendata.
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