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Opendata, web and dolomites

UCARE SIGNED

Uncovering the epigenetic signature of female-specifiC biological networks and key driver genes of coronary ArteRy diseasE

Total Cost €

EC-Contrib. €

Partnership

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UCARE project word cloud

Explore the words cloud of the UCARE project. It provides you a very rough idea of what is the project "UCARE" about.

shown samples tissues trend 51 group endothelial biology human thrombus plasma causes whereas signatures plaques ucare artery cell expression ruptured clinical powered dna free ages pathophysiology diagnostics methylation women gradually closing cad suffer profiles gap refers gene translated move analyze cells men pooling corresponds epigenetic regulatory missed sexes intact sex deaths unravel evident younger lagging data diseased genes underlying utilize diagnoses diagnostic patterns cardiovascular differences worrying biobank trials recognition rupture individual disease atherosclerotic networks aid delayed single diagnosis contributed player convincingly underrepresentation expressed efforts 42 mechanism tissue female plaque mostly vascular erosion hospitalizations systemically coronary clinically

Project "UCARE" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITAIR MEDISCH CENTRUM UTRECHT Organization address address: HEIDELBERGLAAN 100 city: UTRECHT postcode: 3584 CX website: www.umcutrecht.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Netherlands [NL]
Total cost	1˙999˙979 €
EC max contribution	1˙999˙979 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2019-COG
Funding Scheme	ERC-COG
Starting year	2020
Duration (year-month-day)	from 2020-08-31 to 2025-08-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITAIR MEDISCH CENTRUM UTRECHT UNIVERSITAIR MEDISCH CENTRUM UTRECHT Organization address address: HEIDELBERGLAAN 100 city: UTRECHT postcode: 3584 CX website: www.umcutrecht.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (UTRECHT)	coordinator	1˙999˙979.00

Map

Project objective

Cardiovascular disease causes 51% of deaths in women and 42% of deaths in men in Europe. Women are contributing mostly to the worrying trend of increases in hospitalizations for coronary artery disease (CAD) at younger ages. Missed and delayed diagnoses in women are more common than in men, as the pathophysiology of CAD in women is different than in men. Men often have atherosclerotic plaque rupture as underlying mechanism for CAD whereas women more often suffer from plaque erosion. Plaque erosion refers to thrombus formation on top of an intact non-ruptured plaque in the coronary artery.

Early recognition of plaque erosion will, therefore, specifically aid in the diagnosis of CAD in women. However, knowledge on CAD and plaque erosion in women is lagging behind. This is due to the underrepresentation of women in clinical trials for CAD and biobank studies. This gap is now only gradually being recognized in research, but not yet fully addressed as pooling of data from both sexes is still common practice. My research efforts have convincingly contributed to the awareness that sex differences in human diseased vascular tissue are relevant. With my group I have shown that sex differences are specifically evident in regulatory gene networks and key player genes for CAD. This also corresponds with sex-specific epigenetic signatures of atherosclerotic plaques, and human endothelial gene expression patterns.

In UCARE, I propose to utilize vascular tissues and plaque samples from well-powered studies to analyze these by sex to a single-cell level. This approach will identify female-specific key player genes in individual cells of plaques and unravel clinically relevant female-specific biology of CAD and plaque erosion. These findings will be translated to systemically expressed DNA methylation profiles in cell free DNA in plasma to move towards early diagnostics. This is a necessary and challenging step towards closing the diagnostic gap between men and women.

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The information about "UCARE" are provided by the European Opendata Portal: CORDIS opendata.

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evolSingleCellGRN (2019)

Constraint, Adaptation, and Heterogeneity: Genomic and single-cell approaches to understanding the evolution of developmental gene regulatory networks