Opendata, web and dolomites

Evolutionary Neurogenomics

The impact of recent retrotransposon invasions on the evolution of human neural gene expression

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 Evolutionary Neurogenomics project word cloud

Explore the words cloud of the Evolutionary Neurogenomics project. It provides you a very rough idea of what is the project "Evolutionary Neurogenomics" about.

sensitive    human    kznf    types    extra    validate    opens    methylation    previously    dutch    cell    curie    neurological    waves    integrate    activated    locations    zinc    diseases    intimately    recruitment    invasions    health    expression    neuron    cortical    clues    evolution    silenced    disorders    differentiation    opportunity    throughout    attack    retrotransposon    thousands    modules    networks    neuronal    source    group    training    unknown    exploration    gene    individual    mechanism    functionally    genome    neural    odowska    goals    retrotransposons    retrovirus    suggest    evolutionary    genomes    reactivated    finger    aberrantly    novelties    astonishing    cancer    regulatory    dna    restricted    proteins    hold    insertions    classes    sk    showed    assay    correlated    marie    re    50    disease    patterns    krab    primate    genomic    genes    professional    me    mobile    stem    fellowship    suggesting    neurodevelopmental   

Project "Evolutionary Neurogenomics" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITEIT VAN AMSTERDAM 

Organization address
address: SPUI 21
city: AMSTERDAM
postcode: 1012WX
website: www.uva.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Project website http://www.frankjacobslab.com
 Total cost 177˙598 €
 EC max contribution 177˙598 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2015
 Duration (year-month-day) from 2015-06-01   to  2017-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITEIT VAN AMSTERDAM NL (AMSTERDAM) coordinator 177˙598.00

Map

 Project objective

Throughout evolution, primate genomes have been under attack by different classes of retrotransposons, retrovirus-derived mobile DNA elements. As a result, an astonishing ~50% of the human genome is derived from many types of retrotransposons. I previously showed that primate-specific retrotransposon invasions are restricted by primate-specific KRAB zinc finger proteins. These findings suggest that through recruitment to thousands of new genomic locations, KRAB zinc finger proteins have become intimately integrated into pre-existing gene regulatory pathways. Retrotransposons are an important source for evolutionary novelties, but the impact of thousands of human-specific retrotransposon-KZNF regulatory modules on the evolution of human gene expression patterns is unknown. There is increasing evidence that retrotransposons become reactivated during neural differentiation, suggesting that neuronal gene-regulatory networks may be extra sensitive to retrotransposon insertions. Furthermore, new retrotransposon insertions may hold clues to the mechanism of human disease: Even when retrotransposons are efficiently silenced in health, they may become aberrantly activated by changes in DNA methylation observed in neurological diseases and cancer. Using a previously established human and non-human primate stem cell cortical neuron differentiation assay, I will identify, validate and functionally test neurodevelopmental genes that have come under the control of retrotransposons. This will address the impact of recent waves of retrotransposon insertions on the evolution of human neural gene expression patterns and opens up the exploration of how new retrotransposon insertions may be correlated to human neurological disorders. The Marie Skłodowska-Curie individual fellowship will provide the opportunity to establish my research group in Europe and re-integrate in Dutch and EU networks, as well as allow me to achieve my professional development training goals.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "EVOLUTIONARY NEUROGENOMICS" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "EVOLUTIONARY NEUROGENOMICS" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

DNANanoProbes (2019)

Design of light-harvesting DNA-nanoprobes with ratiometric signal amplification for fluorescence imaging of live cells.

Read More  

Photonic Radar (2019)

Implementation of Long Reach Hybrid Photonic Radar System and convergence over FSO and PON Networks

Read More  

MAGIMOX (2019)

Nanometre scale imaging of magnetic perovskite oxide thin films using scanning transmission electron microscopy

Read More