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DisConn SIGNED

Neural drivers of functional disconnectivity in brain disorders

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 DisConn project word cloud

Explore the words cloud of the DisConn project. It provides you a very rough idea of what is the project "DisConn" about.

spontaneous    hubs    basis    disorders    fmri    pathophysiological    developmental    excitatory    events    macroscale    disruption    advent    mysterious    deficits    synchronization    recordings    almost    mouse    impaired    connectivity    directionally    severe    plasticity    elucidate    schizophrenia    silencing    breakdown    hallmark    substrates    rsfmri    communication    unifying    shared    understand    connectopathies    perturbational    manipulations    mechanisms    populations    disrupted    resting    models    synaptic    regional    causal    fostered    back    physiologically    neurophysiological    expanding    pave    co    hierarchical    brain    generation    treat    mechanistic    functional    coupling    description    drives    inhibitory    index    translation    diagnose    aberrant    drivers    relationships    invariably    combination    neuroimaging    probe    cortical    peripheral    network    disconnectivity    vulnerable    cellular    regions    learning    canonical    patterns    uncover    imbalances    awake    organization    occurrence    link    psychiatric    autism    neural    revealed    manipulate    interpretable    map   

Project "DisConn" data sheet

The following table provides information about the project.

Coordinator
FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA 

Organization address
address: VIA MOREGO 30
city: GENOVA
postcode: 16163
website: www.iit.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 1˙498˙125 €
 EC max contribution 1˙498˙125 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-02-01   to  2024-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA IT (GENOVA) coordinator 1˙498˙125.00

Map

 Project objective

A rapidly expanding approach to understanding neural organization is to map patterns of spontaneous neural activity as an index of functional communication and connectivity across brain regions. Fostered by the advent of neuroimaging methods like resting-state fMRI (rsfMRI), this approach has revealed that functional connectivity is almost invariably disrupted in severe psychiatric disorders, such as autism or schizophrenia. However, the neural basis of such functional disconnectivity remains mysterious. What drives brain-wide functional synchronization? And are there shared pathophysiological mechanisms leading to impaired large-scale neural coupling? This project aims to elucidate the neural drivers of macroscale functional connectivity, as well as its breakdown in brain connectopathies. To achieve this goal, I propose a multi-scale perturbational approach to establish causal relationships between specific neural events and brain-wide functional connectivity via a novel combination of rsfMRI and advanced neural manipulations and recordings in the awake mouse. By directionally silencing functional hubs as well as more peripheral cortical regions, I will provide a hierarchical description of spontaneous network organization that will uncover regional substrates vulnerable to network disruption. I will also manipulate physiologically-distinct excitatory or inhibitory populations to probe a unifying mechanistic link between excitatory/inhibitory imbalances and aberrant functional connectivity. Finally, to account for the hallmark co-occurrence of synaptic deficits and functional disconnectivity in developmental disorders, I will link cellular mechanisms of synaptic plasticity and learning to the generation of canonical and aberrant spontaneous activity patterns. These studies will pave the way to a back-translation of aberrant functional connectivity into interpretable neurophysiological events and models that can help understand, diagnose or treat brain disorders.

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The information about "DISCONN" are provided by the European Opendata Portal: CORDIS opendata.

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