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DisConn SIGNED

Neural drivers of functional disconnectivity in brain disorders

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 DisConn project word cloud

Explore the words cloud of the DisConn project. It provides you a very rough idea of what is the project "DisConn" about.

treat    elucidate    neuroimaging    functional    hubs    link    imbalances    uncover    directionally    almost    basis    manipulations    canonical    co    generation    unifying    deficits    translation    schizophrenia    drivers    synaptic    manipulate    advent    inhibitory    vulnerable    revealed    developmental    combination    mechanistic    shared    understand    autism    silencing    connectopathies    index    drives    severe    pave    breakdown    back    populations    coupling    impaired    fostered    spontaneous    psychiatric    brain    recordings    patterns    macroscale    peripheral    excitatory    diagnose    substrates    occurrence    mechanisms    disruption    probe    network    fmri    description    learning    relationships    expanding    map    regional    communication    disconnectivity    synchronization    perturbational    hallmark    connectivity    neurophysiological    events    physiologically    mysterious    regions    disrupted    aberrant    disorders    awake    resting    organization    pathophysiological    neural    cellular    cortical    models    hierarchical    plasticity    interpretable    mouse    rsfmri    causal    invariably   

Project "DisConn" data sheet

The following table provides information about the project.

Coordinator
FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA 

Organization address
address: VIA MOREGO 30
city: GENOVA
postcode: 16163
website: www.iit.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 1˙498˙125 €
 EC max contribution 1˙498˙125 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-02-01   to  2024-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA IT (GENOVA) coordinator 1˙498˙125.00

Map

 Project objective

A rapidly expanding approach to understanding neural organization is to map patterns of spontaneous neural activity as an index of functional communication and connectivity across brain regions. Fostered by the advent of neuroimaging methods like resting-state fMRI (rsfMRI), this approach has revealed that functional connectivity is almost invariably disrupted in severe psychiatric disorders, such as autism or schizophrenia. However, the neural basis of such functional disconnectivity remains mysterious. What drives brain-wide functional synchronization? And are there shared pathophysiological mechanisms leading to impaired large-scale neural coupling? This project aims to elucidate the neural drivers of macroscale functional connectivity, as well as its breakdown in brain connectopathies. To achieve this goal, I propose a multi-scale perturbational approach to establish causal relationships between specific neural events and brain-wide functional connectivity via a novel combination of rsfMRI and advanced neural manipulations and recordings in the awake mouse. By directionally silencing functional hubs as well as more peripheral cortical regions, I will provide a hierarchical description of spontaneous network organization that will uncover regional substrates vulnerable to network disruption. I will also manipulate physiologically-distinct excitatory or inhibitory populations to probe a unifying mechanistic link between excitatory/inhibitory imbalances and aberrant functional connectivity. Finally, to account for the hallmark co-occurrence of synaptic deficits and functional disconnectivity in developmental disorders, I will link cellular mechanisms of synaptic plasticity and learning to the generation of canonical and aberrant spontaneous activity patterns. These studies will pave the way to a back-translation of aberrant functional connectivity into interpretable neurophysiological events and models that can help understand, diagnose or treat brain disorders.

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The information about "DISCONN" are provided by the European Opendata Portal: CORDIS opendata.

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