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Role of Apolipoproteins L in immunity and disease

Total Cost €


EC-Contrib. €






 APOLs project word cloud

Explore the words cloud of the APOLs project. It provides you a very rough idea of what is the project "APOLs" about.

apols    unpublished    dendritic    trypanosome    forming    found    devoid    treat    molecular    genes    plan    endothelial    immunity    primate    l1    belongs    obese    inflammation    pathology    myeloid    viral    preliminary    cells    characterizing    sickness    variation    neutralized    cell    lifespan    opening    extraordinary    antagonizes    inflammatory    work    sra    detection    similarities    induction    laboratory    transgenic    phenotype    cellular    mechanism    stimulus    rhodesiense    expressing    podocytes    indicate    led    antigenic    exhibit    death    bcl2    accounting    sleeping    killing    striking    chronic    pore    escaping    identification    subspecies    resistance    direct    stimuli    neutralize    apol    natural    variants    wild    human    physiological    apoptotic    family    infect    subsequent    mice    pathogenic    apolipoprotein    perspectives    pathogen    kidney    innate    proteins    serum    trypanosoma    activated    neutralization    function    apol1    experiments    protein    trypanosomes    deregulated    humans    conferring    either    disease    suggest   

Project "APOLs" data sheet

The following table provides information about the project.


Organization address
postcode: 1050

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Belgium [BE]
 Total cost 2˙250˙000 €
 EC max contribution 2˙250˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-ADG
 Funding Scheme ERC-ADG
 Starting year 2015
 Duration (year-month-day) from 2015-09-01   to  2021-06-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITE LIBRE DE BRUXELLES BE (BRUXELLES) coordinator 2˙250˙000.00


 Project objective

Work conducted in my laboratory on the trypanosome killing factor of human serum led to the identification of the primate-specific Apolipoprotein L1 (APOL1) as a novel pore-forming protein with striking similarities with proteins of the apoptotic BCL2 family. APOL1 belongs to a family of proteins induced under inflammatory conditions in myeloid and endothelial cells. APOL1 is efficiently neutralized by the SRA protein of Trypanosoma rhodesiense, accounting for the ability of this trypanosome subspecies to infect humans and cause sleeping sickness. We found that natural APOL1 variants escaping SRA neutralization and therefore conferring human resistance to T. rhodesiense are associated with chronic kidney disease. Moreover, transgenic mice expressing these APOL1 variants exhibit an obese phenotype. Our unpublished results also indicate that APOLs control the lifespan of dendritic cells and podocytes activated by viral stimuli. Therefore, we propose that the pathology of APOL variants is due to their deregulated activity on the control of the cellular lifespan in myeloid/endothelial cells activated by pathogen detection. This project aims at characterizing (i) the molecular mechanism by which APOLs control the lifespan of activated dendritic cells and podocytes, which has direct impact on innate immunity and inflammation, and (ii) the mechanism by which APOL1 variants cause pathology. In addition, we plan to detail the physiological function of APOLs by studying the phenotype of transgenic mice either expressing human APOL1 (wild-type and variants) or devoid of APOL genes, which we have recently generated. Finally, we propose to exploit the extraordinary potential of trypanosomes for antigenic variation in order to produce SRA variants able to neutralize the pathogenic APOL1 variants. Preliminary experiments suggest that in podocytes SRA antagonizes APOL1 induction by viral stimulus and subsequent cell death, opening new perspectives to treat kidney disease.


year authors and title journal last update
List of publications.
2016 Bart Cuypers, Laurence Lecordier, Conor J. Meehan, Frederik Van den Broeck, Hideo Imamura, Philippe Büscher, Jean-Claude Dujardin, Kris Laukens, Achim Schnaufer, Caroline Dewar, Michael Lewis, Oliver Balmer, Thomas Azurago, Sardick Kyei-Faried, Sally-Ann Ohene, Boateng Duah, Prince Homiah, Ebenezer Kofi Mensah, Francis Anleah, Jose Ramon Franco, Etienne Pays, Stijn Deborggraeve
Apolipoprotein L1 Variant Associated with Increased Susceptibility to Trypanosome Infection
published pages: , ISSN: 2150-7511, DOI: 10.1128/mBio.02198-15
mBio 7/2 2020-04-01
2017 Frédéric Fontaine, Laurence Lecordier, Gilles Vanwalleghem, Pierrick Uzureau, Nick Van Reet, Martina Fontaine, Patricia Tebabi, Benoit Vanhollebeke, Philippe Büscher, David Pérez-Morga, Etienne Pays
APOLs with low pH dependence can kill all African trypanosomes
published pages: 1500-1506, ISSN: 2058-5276, DOI: 10.1038/s41564-017-0034-1
Nature Microbiology 2/11 2020-03-03
2017 Gilles Vanwalleghem, Yannick Morias, Alain Beschin, David E. Szymkowski, Etienne Pays
Trypanosoma brucei growth control by TNF in mammalian host is independent of the soluble form of the cytokine
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-017-06496-2
Scientific Reports 7/1 2020-03-03

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