Opendata, web and dolomites

MMA SIGNED

Molecular Mechanical Adhesives

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 MMA project word cloud

Explore the words cloud of the MMA project. It provides you a very rough idea of what is the project "MMA" about.

mechanical    mechanically    macroscopic    relied    merge    ligand    clotting    ground    reversible    peo    handles    components    mechanics    liquid    single    complexes    bond    collagen    mimic    settings    mechano    proteins    super    thousands    hampered    domains    tunable    attempts    interpenetrating    times    strength    molecule    coh    adhere    adapt    healing    form    hydrogel    hydrogels    possess    polymers    consisting    dockerin    extracellular    biocompatible    leveraging    sealants    dissipation    stability    combination    gels    designed    networks    macroscale    broken    bulk    designing    molecular    improvements    oligomerized    principles    cohesins    influence    ligands    engineering    am    experiments    spray    doc    made    lies    seamlessly    energy    tissues    poor    gel    self    frontier    covalent    modest    protein    cells    rationally    hypothesis    reformed    bridging    behavior    breaking    pioneered    spontaneously    discoveries    gap    fibrin    matrix    stable    family    modes    nanomechanics    receptor    mixture    adhesives    native    materials    surgical   

Project "MMA" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAT BASEL 

Organization address
address: PETERSPLATZ 1
city: BASEL
postcode: 4051
website: www.unibas.ch

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 1˙466˙916 €
 EC max contribution 1˙466˙916 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-STG
 Funding Scheme ERC-STG
 Starting year 2017
 Duration (year-month-day) from 2017-04-01   to  2022-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAT BASEL CH (BASEL) coordinator 1˙466˙916.00

Map

 Project objective

Protein-based hydrogels are commonly used as adhesives and sealants in surgical settings. Fibrin gels, for example, are biocompatible, however their use is hampered by poor mechanical properties. Previous attempts to improve fibrin gel mechanics relied on interpenetrating networks in combination with PEO, collagen and other polymers, however, only modest improvements were observed. The important challenge lies in understanding how molecular design principles can influence gel mechanics on the macroscale.

The goal of this research is to develop mechanically tunable protein hydrogels. Upon mixture of two liquid components, the systems I propose would spontaneously form a gel matrix consisting of oligomerized proteins that mimic the extracellular matrix and possess controllable mechanical responses. By understanding protein nanomechanics at the single-molecule level, and designing modes of energy dissipation into hydrogel networks, my project will have an impact by bridging the knowledge gap between single-molecule and macroscopic mechanical responses.

My approach is ground-breaking because I am leveraging the discoveries I made on a family of super-stable receptor-ligand proteins (Cohesins & Dockerin (Coh-Doc)). These reversible receptor-ligands can be broken and reformed thousands of times, yet still maintain high stability (1/2 covalent bond strength). After having pioneered the application of these mechano-stable domains as molecular handles in single-molecule experiments, I propose the following frontier research:

A) I will use molecular engineering of Coh-Doc complexes to test the hypothesis that mechanical properties of bulk materials can be rationally designed based on single-molecule mechanical behavior of receptor-ligands. B) I will adapt the system to seamlessly merge with the native fibrin clotting pathway, providing a self-healing mechano-stable fibrin-based gel that could be applied as a liquid or spray and strongly adhere to cells and tissues.

 Publications

year authors and title journal last update
List of publications.
2019 Rafael C. Bernardi, Ellis Durner, Constantin Schoeler, Klara H. Malinowska, Bruna G. Carvalho, Edward A. Bayer, Zaida Luthey-Schulten, Hermann E. Gaub, Michael A. Nash
Mechanisms of Nanonewton Mechanostability in a Protein Complex Revealed by Molecular Dynamics Simulations and Single-Molecule Force Spectroscopy
published pages: 14752-14763, ISSN: 0002-7863, DOI: 10.1021/jacs.9b06776
Journal of the American Chemical Society 141/37 2019-12-16
2019 Haipei Liu, Valentin Schittny, Michael A. Nash
Removal of a Conserved Disulfide Bond Does Not Compromise Mechanical Stability of a VHH Antibody Complex
published pages: 5524-5529, ISSN: 1530-6984, DOI: 10.1021/acs.nanolett.9b02062
Nano Letters 19/8 2019-12-16
2018 Duy Tien Ta, Rosario Vanella, Michael A. Nash
Bioorthogonal Elastin-like Polypeptide Scaffolds for Immunoassay Enhancement
published pages: 30147-30154, ISSN: 1944-8244, DOI: 10.1021/acsami.8b10092
ACS Applied Materials & Interfaces 10/36 2019-05-27
2017 Wolfgang Ott, Markus A. Jobst, Magnus S. Bauer, Ellis Durner, Lukas F. Milles, Michael A. Nash, Hermann E. Gaub
Elastin-like Polypeptide Linkers for Single-Molecule Force Spectroscopy
published pages: 6346-6354, ISSN: 1936-0851, DOI: 10.1021/acsnano.7b02694
ACS Nano 11/6 2019-05-27
2017 Tobias Verdorfer, Rafael C. Bernardi, Aylin Meinhold, Wolfgang Ott, Zaida Luthey-Schulten, Michael A. Nash, Hermann E. Gaub
Combining in Vitro and in Silico Single-Molecule Force Spectroscopy to Characterize and Tune Cellulosomal Scaffoldin Mechanics
published pages: 17841-17852, ISSN: 0002-7863, DOI: 10.1021/jacs.7b07574
Journal of the American Chemical Society 139/49 2019-05-27
2018 Haipei Liu, Duy Tien Ta, Michael A. Nash
Mechanical Polyprotein Assembly Using Sfp and Sortase-Mediated Domain Oligomerization for Single-Molecule Studies
published pages: 1800039, ISSN: 2366-9608, DOI: 10.1002/smtd.201800039
Small Methods 2/6 2019-05-10

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "MMA" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "MMA" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

Resonances (2019)

Resonances and Zeta Functions in Smooth Ergodic Theory and Geometry

Read More  

Aware (2019)

Aiding Antibiotic Development with Deep Analysis of Resistance Evolution

Read More  

PonD (2019)

Particles-on-Demand for Multiscale Fluid Dynamics

Read More