Explore the words cloud of the MMA project. It provides you a very rough idea of what is the project "MMA" about.
The following table provides information about the project.
|Coordinator Country||Switzerland [CH]|
|Total cost||1˙466˙916 €|
|EC max contribution||1˙466˙916 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2017-04-01 to 2022-03-31|
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Protein-based hydrogels are commonly used as adhesives and sealants in surgical settings. Fibrin gels, for example, are biocompatible, however their use is hampered by poor mechanical properties. Previous attempts to improve fibrin gel mechanics relied on interpenetrating networks in combination with PEO, collagen and other polymers, however, only modest improvements were observed. The important challenge lies in understanding how molecular design principles can influence gel mechanics on the macroscale.
The goal of this research is to develop mechanically tunable protein hydrogels. Upon mixture of two liquid components, the systems I propose would spontaneously form a gel matrix consisting of oligomerized proteins that mimic the extracellular matrix and possess controllable mechanical responses. By understanding protein nanomechanics at the single-molecule level, and designing modes of energy dissipation into hydrogel networks, my project will have an impact by bridging the knowledge gap between single-molecule and macroscopic mechanical responses.
My approach is ground-breaking because I am leveraging the discoveries I made on a family of super-stable receptor-ligand proteins (Cohesins & Dockerin (Coh-Doc)). These reversible receptor-ligands can be broken and reformed thousands of times, yet still maintain high stability (1/2 covalent bond strength). After having pioneered the application of these mechano-stable domains as molecular handles in single-molecule experiments, I propose the following frontier research:
A) I will use molecular engineering of Coh-Doc complexes to test the hypothesis that mechanical properties of bulk materials can be rationally designed based on single-molecule mechanical behavior of receptor-ligands. B) I will adapt the system to seamlessly merge with the native fibrin clotting pathway, providing a self-healing mechano-stable fibrin-based gel that could be applied as a liquid or spray and strongly adhere to cells and tissues.
|year||authors and title||journal||last update|
Rafael C. Bernardi, Ellis Durner, Constantin Schoeler, Klara H. Malinowska, Bruna G. Carvalho, Edward A. Bayer, Zaida Luthey-Schulten, Hermann E. Gaub, Michael A. Nash
Mechanisms of Nanonewton Mechanostability in a Protein Complex Revealed by Molecular Dynamics Simulations and Single-Molecule Force Spectroscopy
published pages: 14752-14763, ISSN: 0002-7863, DOI: 10.1021/jacs.9b06776
|Journal of the American Chemical Society 141/37||2019-12-16|
Haipei Liu, Valentin Schittny, Michael A. Nash
Removal of a Conserved Disulfide Bond Does Not Compromise Mechanical Stability of a VHH Antibody Complex
published pages: 5524-5529, ISSN: 1530-6984, DOI: 10.1021/acs.nanolett.9b02062
|Nano Letters 19/8||2019-12-16|
Duy Tien Ta, Rosario Vanella, Michael A. Nash
Bioorthogonal Elastin-like Polypeptide Scaffolds for Immunoassay Enhancement
published pages: 30147-30154, ISSN: 1944-8244, DOI: 10.1021/acsami.8b10092
|ACS Applied Materials & Interfaces 10/36||2019-05-27|
Wolfgang Ott, Markus A. Jobst, Magnus S. Bauer, Ellis Durner, Lukas F. Milles, Michael A. Nash, Hermann E. Gaub
Elastin-like Polypeptide Linkers for Single-Molecule Force Spectroscopy
published pages: 6346-6354, ISSN: 1936-0851, DOI: 10.1021/acsnano.7b02694
|ACS Nano 11/6||2019-05-27|
Tobias Verdorfer, Rafael C. Bernardi, Aylin Meinhold, Wolfgang Ott, Zaida Luthey-Schulten, Michael A. Nash, Hermann E. Gaub
Combining in Vitro and in Silico Single-Molecule Force Spectroscopy to Characterize and Tune Cellulosomal Scaffoldin Mechanics
published pages: 17841-17852, ISSN: 0002-7863, DOI: 10.1021/jacs.7b07574
|Journal of the American Chemical Society 139/49||2019-05-27|
Haipei Liu, Duy Tien Ta, Michael A. Nash
Mechanical Polyprotein Assembly Using Sfp and Sortase-Mediated Domain Oligomerization for Single-Molecule Studies
published pages: 1800039, ISSN: 2366-9608, DOI: 10.1002/smtd.201800039
|Small Methods 2/6||2019-05-10|
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