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LIVERZAP TERMINATED

Live, In vivo Visualisation of liver Regeneration in Zebrafish After Photoablation of hepatocytes

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 LIVERZAP project word cloud

Explore the words cloud of the LIVERZAP project. It provides you a very rough idea of what is the project "LIVERZAP" about.

zebrafish    position    cell    damaged    molecular    static    microscopy    map    regenerative    restore    histological    time    behaviours    temporally    regeneration    driving    liverzap    transparency    insights    photon    imaging    limited    chronic    human    environment    competencies    transplantation    techniques    monitoring    photoactivatable    host    species    functions    fellow    scarring    lost    community    rapid    platform    crucially    capacity    silac    cutting    compromised    liver    optogenetics    deep    metabolic    excellent    edge    remodelling    restoration    rearrangement    specialised    mammalian    screened    regenerating    opacity    injury    cellular    realise    live    mechanisms    fixed    cirrhosis    treatment    outcomes    expertise    surface    location    whereas    tissue    combined    architecture    dynamic    proteomics    pioneering    ablation    hepatocyte    pathologies    vital    generating    hindered    vivo    therapies    tools    protocol    uniquely    disease    organ    larval    suited    body    generate   

Project "LIVERZAP" data sheet

The following table provides information about the project.

Coordinator
KOBENHAVNS UNIVERSITET 

Organization address
address: NORREGADE 10
city: KOBENHAVN
postcode: 1165
website: www.ku.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Total cost 200˙194 €
 EC max contribution 200˙194 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-01-01   to  2019-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KOBENHAVNS UNIVERSITET DK (KOBENHAVN) coordinator 200˙194.00

Map

 Project objective

The specialised tissue architecture of the liver is crucially important for its essential metabolic functions in the body. The liver has the unique regenerative capacity to restore lost architecture when damaged. However, this remodelling process is compromised in chronic liver disease by scarring and cirrhosis. Often the only treatment is organ transplantation, thus the development of novel therapies is of vital importance. The necessary understanding of the dynamic cell rearrangement driving restoration of liver architecture has been limited by temporally static histological analyses of fixed regenerating tissue. Real-time monitoring of the mammalian liver is hindered by tissue opacity and deep organ position, whereas the surface location of the zebrafish liver and larval transparency makes this species uniquely suited for live, in vivo imaging of regeneration. LIVERZAP will generate a detailed map of the different cell behaviours driving restoration of liver architecture by pioneering real-time, in vivo imaging of regeneration in zebrafish. This will be achieved by: i) generating a novel, photoactivatable method for rapid hepatocyte ablation and ii) developing a deep tissue, 2-photon microscopy live imaging protocol. The molecular factors controlling the identified cell behaviours will be screened for using SILAC-based proteomics. To realise LIVERZAP, expertise in liver research, deep tissue microscopy and proteomics within the host environment will be combined with the fellow’s live imaging experience. LIVERZAP will generate excellent new tools for the regeneration community and greatly enhance the fellow’s competencies in specialised techniques, including cutting-edge microscopy systems and optogenetics. The outcomes of LIVERZAP will produce essential insights into the cellular and molecular mechanisms driving restoration of liver architecture following injury, providing a platform for the long-term development of therapies for human liver pathologies.

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The information about "LIVERZAP" are provided by the European Opendata Portal: CORDIS opendata.

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