Opendata, web and dolomites

ShuttleCat SIGNED

Shuttle Catalysis for Reversible Molecular Construction

Total Cost €


EC-Contrib. €






Project "ShuttleCat" data sheet

The following table provides information about the project.


Organization address
address: Raemistrasse 101
postcode: 8092

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 1˙485˙000 €
 EC max contribution 1˙485˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-STG
 Funding Scheme ERC-STG
 Starting year 2018
 Duration (year-month-day) from 2018-01-01   to  2022-12-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

Homogeneous catalysis is one of the pillars of modern chemical synthesis because it enables the sustainable preparation of molecules that find applications in medicinal chemistry, agrochemistry, and materials science. However, many catalytic reactions use hazardous reagents, are unpractical on laboratory-scale or limited in scope. Moreover, while a relatively broad set of catalytic reactions are available to construct chemical bonds, methods to cleave those, which could find applications in biomass and waste valorization, are rare. Inspired by the synthetic power of other metal-catalyzed reversible reactions, such as transfer hydrogenation and alkene metathesis, I herein describe a groundbreaking approach to homogeneous catalysis that makes use of a novel paradigm called “shuttle catalysis”, defined as the catalytic reversible transfer of chemical moieties between two molecules, to construct and deconstruct organic compounds. The first part of the proposal describes the invention of reversible catalytic functionalization reactions of alkenes following this principle. The second part addresses the challenge of developing safer catalytic carbonylation and decarbonylation reactions that do not use nor release toxic carbon monoxide gas. Finally, the last part proposes to apply the shuttle catalysis concept to the invention of unprecedented C–X (X = P, O, S, N) bond metathesis reactions. This new approach to catalysis has the potential to revolutionize the preparation, and streamline the discovery, of numerous important molecules with applications across the molecular sciences. Importantly, in order to mitigate the high risks inherent to such a groundbreaking approach, we have collected preliminary results to demonstrate the feasibility of each of the proposed subprojects.


year authors and title journal last update
List of publications.
2018 Luca Legnani, Gabriele Prina-Cerai, Tristan Delcaillau, Suzanne Willems, Bill Morandi
Efficient access to unprotected primary amines by iron-catalyzed aminochlorination of alkenes
published pages: 434-439, ISSN: 0036-8075, DOI: 10.1126/science.aat3863
Science 362/6413 2020-03-05
2019 Yong Ho Lee, Bill Morandi
Transition metal-mediated metathesis between P–C and M–C bonds: Beyond a side reaction
published pages: 96-118, ISSN: 0010-8545, DOI: 10.1016/j.ccr.2018.12.001
Coordination Chemistry Reviews 386 2020-03-05
2018 Tobias Biberger, Szabolcs Makai, Zhong Lian, Bill Morandi
Iron-Catalyzed Ring-Closing C−O/C−O Metathesis of Aliphatic Ethers
published pages: 6940-6944, ISSN: 1433-7851, DOI: 10.1002/anie.201802563
Angewandte Chemie International Edition 57/23 2020-03-05
2019 Benjamin N. Bhawal, Bill Morandi
Catalytic Isofunctional Reactions-Expanding the Repertoire of Shuttle and Metathesis Reactions
published pages: 10074-10103, ISSN: 1433-7851, DOI: 10.1002/anie.201803797
Angewandte Chemie International Edition 58/30 2020-03-05
2019 Yong Ho Lee, Bill Morandi
Palladium-Catalyzed Intermolecular Aryliodination of Internal Alkynes
published pages: 6444-6448, ISSN: 1433-7851, DOI: 10.1002/anie.201812396
Angewandte Chemie International Edition 58/19 2020-03-05
2020 Tristan Delcaillau, Alessandro Bismuto, Zhong Lian, Bill Morandi
Nickel-Catalyzed Inter- and Intramolecular Aryl Thioether Metathesis by Reversible Arylation
published pages: 2110-2114, ISSN: 1433-7851, DOI: 10.1002/anie.201910436
Angewandte Chemie International Edition 59/5 2020-03-05
2020 Peng Yu, Alessandro Bismuto, Bill Morandi
Iridium-Catalyzed Hydrochlorination and Hydrobromination of Alkynes by Shuttle Catalysis
published pages: 2904-2910, ISSN: 1433-7851, DOI: 10.1002/anie.201912803
Angewandte Chemie International Edition 59/7 2020-03-05
2019 Xianjie Fang, Peng Yu, Suzanne Willems, Bill Morandi
Nickel‐Catalyzed Cascade Annulation for the Rapid Synthesis of Carbocyclic Nitriles
published pages: e1900059, ISSN: 0018-019X, DOI: 10.1002/hlca.201900059
Helvetica Chimica Acta 102/5 2020-03-05

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "SHUTTLECAT" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email ( and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "SHUTTLECAT" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)


The Enemy of the Good: Towards a Theory of Moral Progress

Read More  


The Mass Politics of Disintegration

Read More  

Neurovulnerability (2019)

Molecular mechanisms underlying selective neuronal death in motor neuron diseases

Read More