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HelpUS SIGNED

Pioneering focused Ultrasounds as a new non-invasive deep brain stimulation for a causal investigation of empathy related brain processes in moral learning and decision making

Total Cost €

0

EC-Contrib. €

0

Partnership

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 HelpUS project word cloud

Explore the words cloud of the HelpUS project. It provides you a very rough idea of what is the project "HelpUS" about.

affective    structures    alter    decision    compare    models    harm    cognition    fmri    mechanistic    motivating    computational    transformed    humans    nature    deeper    brain    antisocial    stead    showing    modulate    unleash    individuals    inform    learning    us    stimulation    prosociality    empathy    self    frustratingly    painful    stop    feel    disorders    noninvasively    hypothesis    anterior    equation    cooperate    testable    selectively    kicking    social    successful    had    incorporate    associating    causal    thereby    vicarious    transform    hypotheses    context    ultrasounds    transforming    expression    kick    relationship    explore    barrier    negative    provides    kicked    depends    select    altering    limbic    insula    actions    cingulate    balance    suggesting    behavior    friend    tools    brake    interventions    optimize    benefits    brand    leaning    captures    representation    remained    neural    neuroscience    pave    push    themselves    deep    pain    emotions    outcomes    untreatable    facial    regions    generally    cooperation    powerless    currency   

Project "HelpUS" data sheet

The following table provides information about the project.

Coordinator
KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW 

Organization address
address: KLOVENIERSBURGWAL 29 HET TRIPPENHUIS
city: AMSTERDAM
postcode: 1011 JV
website: www.knaw.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 1˙500˙000 €
 EC max contribution 1˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-STG
 Funding Scheme ERC-STG
 Starting year 2018
 Duration (year-month-day) from 2018-07-01   to  2023-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW NL (AMSTERDAM) coordinator 1˙500˙000.00

Map

 Project objective

The success of humans depends on their ability to cooperate. Cooperation requires learning to avoid actions that harm others and select those that balance benefits for self and others. Reinforcement leaning captures how individuals learn to optimize benefits for themselves, by associating actions and outcomes for the self. The social context requires to incorporate outcomes for others into that equation by transforming them into the currency used to value our own outcomes. Research on empathy, by suggesting that we transform the emotions of others into neural representation of how we would feel in their stead, provides testable mechanistic hypotheses of how we do that. The painful facial expression of our friend after we kick him would be transformed into the pain we would feel when kicked, associating kicking with negative value, thereby motivating us to stop kicking. Testing this hypothesis would require altering brain activity in the anterior insula and cingulate involved in this process, and showing that these changes alter decision making. Because current tools in humans cannot selectively modulate activity in these deeper regions we however remain frustratingly powerless to do so. Here we will develop a brand new method using ultrasounds to modulate brain activity at any depth to brake down this barrier. Using fmri, we will measure vicarious activity and compare it with computational models. This will push our understanding of our social nature to a new computational level, and pave the way to a more causal understanding of prosociality that can inform successful interventions for so far untreatable antisocial disorders. More generally deep brain stimulation via US, and the understanding of how US modulate brain activity, will unleash affective neuroscience to noninvasively explore what had remained beyond our reach: the causal relationship between deeper (limbic) structures and behavior and cognition.

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The information about "HELPUS" are provided by the European Opendata Portal: CORDIS opendata.

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