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MagnetoVirology SIGNED

Diamond Magnetometry: A Versatile Tool for Virology and Medicine

Total Cost €

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EC-Contrib. €

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Partnership

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 MagnetoVirology project word cloud

Explore the words cloud of the MagnetoVirology project. It provides you a very rough idea of what is the project "MagnetoVirology" about.

possibility    claim    nanodiamonds    species    2020    radicals    detection    detecting    measuring    clinical    detrimental    collaborative    biotechnology    sensitivity    volume    patients    technique    bhc    conclude    fluorescent    cellular    oxygen    sc1    diamond    animal    outcome    fundamental    therapy    nmbp    mediating    elucidated    reactive    completion    industry    synovial    viral    programs    interdisciplinary    kinetics    virology    pathogenesis    free    host    virus    demonstrating    fnds    interplay    diagnostics    deeper    depends    drug    spatiotemporal    small    biology    exact    pharmaceutical    underscored    t1    point    complicated    inside    arthritis    usefulness    fr    unparalleled    nanotechnology    highlight    successful    ros    magnetometry    resolution    horizon    oxidants    toward    intend    relaxation    infection    time    centers    model    potentially    sindbis    vacancy    fluid    limitations    nitrogen    probe    cell    anti    health    quantified    infections    sinv    aligns    cells    opposite    dt   

Project "MagnetoVirology" data sheet

The following table provides information about the project.

Coordinator
ACADEMISCH ZIEKENHUIS GRONINGEN 

Organization address
address: HANZEPLEIN 1
city: GRONINGEN
postcode: 9713 GZ
website: www.umcg.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 187˙572 €
 EC max contribution 187˙572 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-07-01   to  2021-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ACADEMISCH ZIEKENHUIS GRONINGEN NL (GRONINGEN) coordinator 187˙572.00

Map

 Project objective

Reactive Oxygen Species (ROS)/ free radicals (FR) in cells have a very complicated role in viral infections. While some researchers point toward their usefulness in mediating viral infections, others conclude the exact opposite and claim that there are detrimental effects. To probe deeper into virus pathogenesis and improve anti-viral therapy, cellular FR - viral infection kinetics which potentially depends on virus, cell/animal model, type of reactive species, etc. needs to be investigated with high spatiotemporal resolution. However, all the traditional methods capable of detecting FR have limitations when real-time, long-duration, high resolution measurements are to be conducted within a small sample volume (inside of a cell). Recently, diamond magnetometry was proposed to study cellular FR with unparalleled sensitivity, resolution, and the possibility of real-time long-duration measurements. In this highly interdisciplinary collaborative research, I aim to establish this technique in studying cellular FR- viral infections kinetics. As a model system I will investigate the host cell FR response upon Sindbis virus (SINV) infection with high spatiotemporal resolution. FR response will be quantified via measuring T1 relaxation time of Nitrogen Vacancy centers in fluorescent nanodiamonds (FNDs). Furthermore, I intend to highlight the potential of diamond magnetometry in clinical diagnostics and drug development by demonstrating the FR detection in synovial fluid of arthritis patients (outcome of SINV infection) and detecting cells’ FR response to anti- oxidants. Upon successful completion, I will not only have elucidated the interplay of FR and SINV infections but also underscored the potential of diamond magnetometry in fundamental virology, infection biology, clinical diagnostics and pharmaceutical industry. This research strongly aligns with two work programs within Horizon 2020 focused on health (SC1-BHC) and nanotechnology- biotechnology (DT-NMBP).

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