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BioNanoProbes SIGNED

Bio-Inspired Glycan-NanoProbes as Antimicrobial Pro-Drugs

Total Cost €

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EC-Contrib. €

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Partnership

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 BioNanoProbes project word cloud

Explore the words cloud of the BioNanoProbes project. It provides you a very rough idea of what is the project "BioNanoProbes" about.

degradative    group    amr    cell    disaccharide    antibiotics    densities    largely    accessible    positive    counter    possibility    nanoparticle    fluorescent    architecture    mechanisms    relative    endosomal    ligand    ligands    internalizable    nano    bacteria    excitingly    nanopartiples    lactose    nanomaterials    label    toward    soluble    chemistry    adhesion    roles    binding    microbiology    gram    nanodots    mucosal    interactions    release    qds    functionalized    molecules    recognition    screened    host    synthetic    preliminary    antimicrobial    negative    manner    starting    carbohydrates    easily    moieties    cdse    pro    confocal    multivalent    killing    exhibit    multidisciplinary    methods    play    labelling    protein    demonstrated    assays    drug    microscopy    class    affinity    surface    nanoprobes    trojan    clusters    intracellular    presenting    selective    toxic    horse    galan    compensated    glycan    lysosomal    bi    weak    shown    data    carbohydrate    bacterial    drugs    affinities    specificity    attaching    nature    tem    cheap    materials    resistance    glycobiology    act    carbon    glyco    organic    water   

Project "BioNanoProbes" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY OF BRISTOL 

Organization address
address: BEACON HOUSE QUEENS ROAD
city: BRISTOL
postcode: BS8 1QU
website: www.bristol.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
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 Coordinator Country United Kingdom [UK]
 Total cost 212˙933 €
 EC max contribution 212˙933 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-05-01   to  2021-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY OF BRISTOL UK (BRISTOL) coordinator 212˙933.00

Map

 Project objective

Methods for specific recognition and targeting of bacteria are of key importance in developing approaches to counter the growth of antimicrobial resistance (AMR). Cell surface carbohydrates play key roles in cell recognition mechanisms and bacterial adhesion. These key interactions typically exhibit high specificity and weak affinities toward their carbohydrate ligand. This low affinity is compensated in nature by the architecture of the protein, the host presenting the carbohydrate ligands in a multivalent manner or as clusters on the cell or mucosal surface. Glyco-nanomaterials offer the possibility of attaching several different molecules to the same nanoparticle while controlling the relative densities of these ligands. Recently, the Galan group demonstrated that a simple disaccharide, such as lactose can act as a “Trojan horse” on bi-functionalized fluorescent nanopartiples (CdSe QDs) to help intracellular delivery of other non-internalizable glycan moieties and largely avoid the endosomal/lysosomal degradative pathway. Following this, the group has developed a new class of water-soluble, non-toxic fluorescent carbon-based nanomaterials which are easily accessible from cheap carbohydrate starting materials and more excitingly, preliminary data have shown that these new carbon nanodots are able to label both Gram-negative and Gram-positive bacteria. Based on these exciting results, the aim of this project is to develop a new class of glycan-based nanoprobes for labelling and delivery of antibiotics into bacteria. The glycan-based nano pro-drugs will be evaluated in bacterial binding and killing assays and screened for selective labelling and drug release using confocal microscopy and TEM. This is a multidisciplinary project involving synthetic organic and materials chemistry, glycobiology and microbiology.

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The information about "BIONANOPROBES" are provided by the European Opendata Portal: CORDIS opendata.

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