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BioNanoProbes SIGNED

Bio-Inspired Glycan-NanoProbes as Antimicrobial Pro-Drugs

Total Cost €

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EC-Contrib. €

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Partnership

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 BioNanoProbes project word cloud

Explore the words cloud of the BioNanoProbes project. It provides you a very rough idea of what is the project "BioNanoProbes" about.

carbohydrate    nanoprobes    toxic    drug    nano    easily    presenting    horse    functionalized    amr    carbohydrates    binding    accessible    glyco    nature    shown    soluble    internalizable    selective    act    nanodots    affinity    interactions    affinities    drugs    demonstrated    gram    degradative    water    attaching    surface    counter    protein    manner    preliminary    bacterial    positive    assays    confocal    toward    organic    bacteria    methods    bi    trojan    largely    microscopy    excitingly    intracellular    release    microbiology    chemistry    specificity    clusters    antimicrobial    nanomaterials    possibility    qds    tem    molecules    pro    class    labelling    killing    architecture    fluorescent    starting    nanopartiples    group    galan    nanoparticle    synthetic    adhesion    ligands    cheap    multivalent    recognition    screened    glycobiology    host    lysosomal    data    exhibit    play    label    lactose    mechanisms    weak    carbon    compensated    densities    ligand    cell    materials    disaccharide    moieties    multidisciplinary    glycan    negative    roles    antibiotics    cdse    mucosal    resistance    relative    endosomal   

Project "BioNanoProbes" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY OF BRISTOL 

Organization address
address: BEACON HOUSE QUEENS ROAD
city: BRISTOL
postcode: BS8 1QU
website: www.bristol.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
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 Coordinator Country United Kingdom [UK]
 Total cost 212˙933 €
 EC max contribution 212˙933 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-05-01   to  2021-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY OF BRISTOL UK (BRISTOL) coordinator 212˙933.00

Map

 Project objective

Methods for specific recognition and targeting of bacteria are of key importance in developing approaches to counter the growth of antimicrobial resistance (AMR). Cell surface carbohydrates play key roles in cell recognition mechanisms and bacterial adhesion. These key interactions typically exhibit high specificity and weak affinities toward their carbohydrate ligand. This low affinity is compensated in nature by the architecture of the protein, the host presenting the carbohydrate ligands in a multivalent manner or as clusters on the cell or mucosal surface. Glyco-nanomaterials offer the possibility of attaching several different molecules to the same nanoparticle while controlling the relative densities of these ligands. Recently, the Galan group demonstrated that a simple disaccharide, such as lactose can act as a “Trojan horse” on bi-functionalized fluorescent nanopartiples (CdSe QDs) to help intracellular delivery of other non-internalizable glycan moieties and largely avoid the endosomal/lysosomal degradative pathway. Following this, the group has developed a new class of water-soluble, non-toxic fluorescent carbon-based nanomaterials which are easily accessible from cheap carbohydrate starting materials and more excitingly, preliminary data have shown that these new carbon nanodots are able to label both Gram-negative and Gram-positive bacteria. Based on these exciting results, the aim of this project is to develop a new class of glycan-based nanoprobes for labelling and delivery of antibiotics into bacteria. The glycan-based nano pro-drugs will be evaluated in bacterial binding and killing assays and screened for selective labelling and drug release using confocal microscopy and TEM. This is a multidisciplinary project involving synthetic organic and materials chemistry, glycobiology and microbiology.

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The information about "BIONANOPROBES" are provided by the European Opendata Portal: CORDIS opendata.

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