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BioNanoProbes SIGNED

Bio-Inspired Glycan-NanoProbes as Antimicrobial Pro-Drugs

Total Cost €

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EC-Contrib. €

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Partnership

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 BioNanoProbes project word cloud

Explore the words cloud of the BioNanoProbes project. It provides you a very rough idea of what is the project "BioNanoProbes" about.

cell    affinities    moieties    recognition    compensated    trojan    relative    glycan    toxic    galan    release    clusters    mechanisms    architecture    weak    adhesion    ligand    fluorescent    counter    class    methods    data    starting    drug    multivalent    tem    materials    attaching    chemistry    functionalized    host    largely    bi    possibility    nature    pro    glyco    manner    drugs    specificity    nanoparticle    nanopartiples    nanomaterials    nano    endosomal    gram    protein    carbon    microscopy    interactions    soluble    confocal    selective    affinity    internalizable    roles    antimicrobial    cheap    accessible    molecules    binding    exhibit    densities    bacteria    ligands    bacterial    qds    assays    nanoprobes    act    degradative    nanodots    screened    horse    group    amr    microbiology    positive    resistance    label    synthetic    cdse    excitingly    intracellular    killing    carbohydrates    glycobiology    organic    play    negative    mucosal    antibiotics    lysosomal    carbohydrate    multidisciplinary    demonstrated    labelling    disaccharide    water    preliminary    toward    shown    presenting    surface    lactose    easily   

Project "BioNanoProbes" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY OF BRISTOL 

Organization address
address: BEACON HOUSE QUEENS ROAD
city: BRISTOL
postcode: BS8 1QU
website: www.bristol.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
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 Coordinator Country United Kingdom [UK]
 Total cost 212˙933 €
 EC max contribution 212˙933 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-05-01   to  2021-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY OF BRISTOL UK (BRISTOL) coordinator 212˙933.00

Map

 Project objective

Methods for specific recognition and targeting of bacteria are of key importance in developing approaches to counter the growth of antimicrobial resistance (AMR). Cell surface carbohydrates play key roles in cell recognition mechanisms and bacterial adhesion. These key interactions typically exhibit high specificity and weak affinities toward their carbohydrate ligand. This low affinity is compensated in nature by the architecture of the protein, the host presenting the carbohydrate ligands in a multivalent manner or as clusters on the cell or mucosal surface. Glyco-nanomaterials offer the possibility of attaching several different molecules to the same nanoparticle while controlling the relative densities of these ligands. Recently, the Galan group demonstrated that a simple disaccharide, such as lactose can act as a “Trojan horse” on bi-functionalized fluorescent nanopartiples (CdSe QDs) to help intracellular delivery of other non-internalizable glycan moieties and largely avoid the endosomal/lysosomal degradative pathway. Following this, the group has developed a new class of water-soluble, non-toxic fluorescent carbon-based nanomaterials which are easily accessible from cheap carbohydrate starting materials and more excitingly, preliminary data have shown that these new carbon nanodots are able to label both Gram-negative and Gram-positive bacteria. Based on these exciting results, the aim of this project is to develop a new class of glycan-based nanoprobes for labelling and delivery of antibiotics into bacteria. The glycan-based nano pro-drugs will be evaluated in bacterial binding and killing assays and screened for selective labelling and drug release using confocal microscopy and TEM. This is a multidisciplinary project involving synthetic organic and materials chemistry, glycobiology and microbiology.

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The information about "BIONANOPROBES" are provided by the European Opendata Portal: CORDIS opendata.

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