FISHFORPHARMA

Training Network on Zebrafish Infection Models for Pharmaceutical Screens

Coordinatore	UNIVERSITEIT LEIDEN    more  Organization address address: RAPENBURG 70 city: LEIDEN postcode: 2300 RA contact info Titolo: Mr. Nome: Ton Cognome: Brouwer Email: send email Telefono: +31 71 5273149 Fax: +31 71 5275269
Nazionalità Coordinatore	Netherlands [NL]
Totale costo	3˙741˙745 €
EC contributo	3˙741˙745 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2011-ITN
Funding Scheme	MC-ITN
Anno di inizio	2012
Periodo (anno-mese-giorno)	2012-01-01   -   2015-12-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	UNIVERSITEIT LEIDEN  Organization address address: RAPENBURG 70 city: LEIDEN postcode: 2300 RA contact info Titolo: Mr. Nome: Ton Cognome: Brouwer Email: send email Telefono: +31 71 5273149 Fax: +31 71 5275269	NL (LEIDEN)	coordinator	838˙675.75
2	THE UNIVERSITY OF SHEFFIELD  Organization address address: FIRTH COURT WESTERN BANK city: SHEFFIELD postcode: S10 2TN contact info Titolo: Ms. Nome: Joanne Cognome: Watson Email: send email Telefono: 441142000000 Fax: +44114 2221455	UK (SHEFFIELD)	participant	524˙600.98
3	INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE  Organization address address: Rue De L'Universite 147 city: PARIS CEDEX 07 postcode: 75338 contact info Titolo: Dr. Nome: Bernard Cognome: Delmas Email: send email Telefono: 134652627 Fax: 134652591	FR (PARIS CEDEX 07)	participant	510˙391.18
4	AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS  Organization address address: CALLE SERRANO 117 city: MADRID postcode: 28006 contact info Titolo: Mr. Nome: Eusebio Cognome: Jiménez Arroyo Email: send email Telefono: +34 91 566 8852 Fax: +34 91 566 89 13	ES (MADRID)	participant	458˙609.80
5	WAGENINGEN UNIVERSITY  Organization address address: DROEVENDAALSESTEEG 4 city: WAGENINGEN postcode: 6708 PB contact info Titolo: Ms. Nome: Gerda Cognome: Bakker Email: send email Telefono: +31 317 483382 Fax: +31 317 483955	NL (WAGENINGEN)	participant	265˙833.70
6	CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE  Organization address address: Rue Michel -Ange 3 city: PARIS postcode: 75794 contact info Titolo: Dr. Nome: Jocelyn Cognome: Mere Email: send email Telefono: +33 467613535 Fax: +33 4 67043236	FR (PARIS)	participant	254˙095.62
7	INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)  Organization address address: 101 Rue de Tolbiac city: PARIS postcode: 75654 contact info Titolo: Mr. Nome: Vincent Cognome: Boyer Email: send email Telefono: 33467636146 Fax: 33467637025	FR (PARIS)	participant	254˙095.60
8	EUROPEAN MOLECULAR BIOLOGY LABORATORY  Organization address address: Meyerhofstrasse 1 city: HEIDELBERG postcode: 69117 contact info Titolo: Dr. Nome: Phil Cognome: Irving Email: send email Telefono: 4962210000000 Fax: 4962210000000	DE (HEIDELBERG)	participant	226˙626.42
9	ZF-SCREENS BV  Organization address address: J H OORTWEG 19 city: LEIDEN postcode: 2333 CH contact info Titolo: Mr. Nome: Pieter Cognome: Slijkerman Email: send email Telefono: +31 71 3322270	NL (LEIDEN)	participant	211˙850.10
10	GLAXOSMITHKLINE INVESTIGACION Y DESARROLLO SL  Organization address address: C/ SANTIAGO GRISOLIA 4 city: TRES CANTOS postcode: 28760 contact info Titolo: Ms. Nome: Elena Cognome: Lopez Email: send email Telefono: 34918075956 Fax: 34918070550	ES (TRES CANTOS)	participant	196˙966.00

Mappa

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 Obiettivo del progetto (Objective)

'Infectious diseases caused by pathogenic micro-organisms are major causes of death, disability, and social and economic disruption for millions of people. During evolution these pathogens have developed intricate strategies to manipulate host defence mechanisms and outwit the immune system. To reduce the burden of infectious diseases it is important to increase understanding of these host-pathogen interaction mechanisms and to develop more effective strategies for drug discovery. The zebrafish holds much promise as a high-throughput drug screening model. In the last few years, zebrafish models for studying human pathogens or closely related animal pathogens have emerged at a rapid pace. The fact that zebrafish produce large amounts of embryos, which develop externally and are optically transparent, gives unprecedented possibilities for live imaging of disease processes and is the basis of novel high-thoughput drug screening approaches. In recent years good models have been developed for toxicity, safety and efficacy of drug screening in zebrafish embryos. However, the major bottleneck for development of high-throughput antimicrobial drug screens has been that infection models rely on manual injection and handling of zebrafish embryos. This limiting factor has been overcome by a unique automated injection system that will be applied in this project. The FishForPharma training network brings together leading European research groups that have pioneered the use of zebrafish infection models and partners from the Biotech and Pharma sectors that aim to commercialise zebrafish tools for biomedical applications. FishForPharma aims to deliver the proof-of-principle for drug discovery using zebrafish infectious disease models and to increase understanding of host-pathogen interaction mechanisms to identify new drug targets for infectious disease treatment. Most importantly, we aim to equip a cohort of young researchers with the knowledge and skills to achieve these goals.'