OBESITY AND LIGHT

Bringing Obesity to Light - Do obesogenic chemicals affect lipid metabolism through changes in circadian rhythm?

Coordinatore	STICHTING VU-VUMC    more  Organization address address: DE BOELELAAN 1105 city: AMSTERDAM postcode: 1081 HV contact info Titolo: Dr. Nome: Yvonne Cognome: Kops Email: send email Telefono: +31 20598400 Fax: +31 205989553
Nazionalità Coordinatore	Netherlands [NL]
Totale costo	183˙805 €
EC contributo	183˙805 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2011-IEF
Funding Scheme	MC-IEF
Anno di inizio	2013
Periodo (anno-mese-giorno)	2013-01-15   -   2015-01-14

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	STICHTING VU-VUMC  Organization address address: DE BOELELAAN 1105 city: AMSTERDAM postcode: 1081 HV contact info Titolo: Dr. Nome: Yvonne Cognome: Kops Email: send email Telefono: +31 20598400 Fax: +31 205989553	NL (AMSTERDAM)	coordinator	183˙805.80

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 Obiettivo del progetto (Objective)

'Bringing light to obesity will elucidate the interconnecting steps of two important signaling pathways i.e. circadian signaling and lipid metabolism. An increase in serum cholesterol level in shift workers indicates this link. Also obesogenic chemicals might influence lipid metabolism through changes in circadian rhythm. Research on obesity has gained in importance as the number of affected patients increases world-wide. The WHO lists five European countries in the top 23 states regarding obesity incidence. Moreover, the mounting healthcare costs turn obesity research to a hot topic. With OBELIX and EUCLOCK the EU already funds projects on obesity and circadian rhythm. This proposal joins both topics and links them to toxicology. The main goal is to study the role of circadian rhythm in lipid metabolism and obesogenic effects of chemicals. To elucidate the signaling pathway of environmentally induced obesity the zebrafish a model for genetic and physiological studies will be used. How do alterations in circadian rhythmicity influence lipid metabolism? How do the clock gene rev-erbα and the peroxisome proliferator activated receptors connect circadian and metabolic signaling pathways? Do obesogenic chemicals influence lipid metabolism through changes in circadian rhythm? A multidisciplinary approach will be made using toxicological, physiological, molecular biological and genetic methods in wildtype and transgenic zebrafish larvae and cells. The project will be done at Dr. Juliette Legler’s lab at the Institute of Environmental Studies at the VU University Amsterdam. Dr. Legler already proved to be an expert in ecotoxicological studies in particular regarding obesogenic chemicals. In addition her broad experience in project management and scientific supervision will allow the applicant to reach her scientific goals like enhancing scientific skills and gaining research experience which will be essential to reach professional maturity.'