PAIN-OMICS

Multi-dimensional omics approach to stratification of patients with low back pain

Coordinatore	UNIVERSITA DEGLI STUDI DI PARMA    more  Organization address address: VIA UNIVERSITA 12 city: PARMA postcode: 43100 contact info Titolo: Prof. Nome: Massimo Cognome: Allegri Email: send email Telefono: +39 0521 703374
Nazionalità Coordinatore	Italy [IT]
Totale costo	8˙576˙693 €
EC contributo	5˙998˙886 €
Programma	FP7-HEALTH Specific Programme "Cooperation": Health
Code Call	FP7-HEALTH-2013-INNOVATION-1
Funding Scheme	CP-FP
Anno di inizio	2013
Periodo (anno-mese-giorno)	2013-09-01   -   2018-08-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	UNIVERSITA DEGLI STUDI DI PARMA  Organization address address: VIA UNIVERSITA 12 city: PARMA postcode: 43100 contact info Titolo: Prof. Nome: Massimo Cognome: Allegri Email: send email Telefono: +39 0521 703374	IT (PARMA)	coordinator	1˙156˙980.00
2	GENOS DOO ZA VJESTACENJE I ANALIZU  Organization address address: Vatrogasna 112 city: Osijek postcode: 31000 contact info Titolo: Mrs. Nome: Cizmesija Cognome: Ivana Email: send email Telefono: 38512352661	HR (Osijek)	participant	990˙300.00
3	HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH  Organization address address: Ingolstaedter Landstrasse 1 city: MUENCHEN postcode: 85764 contact info Titolo: Dr. Nome: Juergen Cognome: Ertel Email: send email Telefono: +49 89 3187 3022	DE (MUENCHEN)	participant	750˙364.00
4	"SPECIJALNA BOLNICA ZA ORTOPEDIJU, KIRURGIJU, NEUROLOGIJU I FIZIKALNU MEDICINU I REHABILITACIJU SVETA KATARINA USTANOVA"  Organization address address: BRACAK 8 city: ZABOK postcode: 49210 contact info Titolo: Prof. Nome: Dragan Cognome: Primorac Email: send email Telefono: 38598470710	HR (ZABOK)	participant	669˙300.00
5	THE CENTER FOR CLINICAL RESEARCH LLC  Organization address address: KIMEL PARK DRIVE 145 SUITE 330 city: WINSTON SALEM postcode: 27103 contact info Titolo: Dr. Nome: Leonardo Cognome: Kapural Email: send email Telefono: +1 3367148381 Fax: 13367658492	US (WINSTON SALEM)	participant	581˙020.00
6	KING'S COLLEGE LONDON  Organization address address: Strand city: LONDON postcode: WC2R 2LS contact info Titolo: Mr. Nome: Paul Cognome: Labbett Email: send email Telefono: +44 020 78488184 Fax: 442078000000	UK (LONDON)	participant	524˙124.00
7	IP RESEARCH CONSULTING SASU  Organization address address: QUAI DES DEUX PONTS 31 city: NOISY LE GRAND postcode: 93160 contact info Titolo: Dr. Nome: Iain Cognome: Pemberton Email: send email Telefono: +33 1 58842557	FR (NOISY LE GRAND)	participant	359˙900.00
8	AULCHENKO YURY SERGEYEVICH  Organization address address: DE SAVORNIN LOHMANLAAN 19 A city: GRONINGEN postcode: 9722 HC contact info Titolo: Dr. Nome: Yury Cognome: Aulchenko Email: send email Telefono: 31648712695	NL (GRONINGEN)	participant	324˙498.00
9	ZIEKENHUIS OOST-LIMBURG AUTONOME VERZORGINGSINSTELLING  Organization address address: SCHIEPSE BOS 6 city: GENK postcode: 3600 contact info Titolo: Mrs. Nome: Joke Cognome: Vanlangenaeker Email: send email Telefono: 3289321324	BE (GENK)	participant	322˙400.00
10	FONDAZIONE IRCCS POLICLINICO SAN MATTEO  Organization address address: VIALE GOLGI 19 city: PAVIA postcode: 27100 contact info Titolo: Mr. Nome: Franco Cognome: Marazza Email: send email Telefono: +39 0382 503550 Fax: +39 0382 502508	IT (PAVIA)	participant	320˙000.00
11	Edith Cowan University  Organization address address: Joondalup Drive 270 city: Joondalup postcode: 6027 contact info Titolo: Ms. Nome: Linda Cognome: Penny Email: send email Telefono: 61863045473	AU (Joondalup)	participant	0.00

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 Obiettivo del progetto (Objective)

'Pain-OMICS is a multidisciplinary consortium of leading clinical, academic and SME researchers in pain and different omics technologies. Genome-wide association studies identified a number of loci associated with pain, but the level of knowledge about underlying mechanisms of different pain syndromes as well as individual variation in the disease course remains inadequate. Pain-OMICS will capitalise on its existing high quality clinical, genetic, biochemical and pharmacological data and biological samples on over 5000 well characterised patients with low-back pain (LBP) and controls available to our EU and US clinical partners. We will exploit novel technological approaches made available through the expertise and global leading position of our analytical partners. These comprise cutting edge genomic, epigenomic, glycomic, and activomic approaches which reflect signal transduction and membrane dynamics. We believe that the inclusion of these complementary analyses will elucidate pathways through which acute LBP fails to resolve and becomes chronic LBP. In addition, these approaches will reveal pathways and biomarkers of chronic pain through which individual differences affects symptoms and response to therapy. Participation of leading clinics on both sides of the Atlantic will enable replication of all finding in at least three independent large cohorts, as well as in prospective study and a large twin cohort. A complex systems biology approach will be used to integrate, interrogate and understand this multidimensional dataset in order to achieve the aims of identifying novel diagnostic and prognostic biomarkers as well as new targets for therapeutic intervention. The track record of achievement of our partners coupled to participation of research-intensive SMEs is a strong indication that the ambitious work programme will be achieved and provides a framework for rapid translation of research discoveries into solutions for the benefit of large numbers of patients.'