INTEGER

Integrated approaches to study gene regulation during cellular differentiation

Coordinatore	BIOMEDICAL SCIENCES RESEARCH CENTER ALEXANDER FLEMING    more  Organization address address: Al. Fleming Street 34 city: VARI-ATHENS postcode: 16672 contact info Titolo: Dr. Nome: John Cognome: Strouboulis Email: send email Telefono: -8970232 Fax: -8979888
Nazionalità Coordinatore	Greece [EL]
Totale costo	2˙300˙000 €
EC contributo	2˙300˙000 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2007-1-1-ITN
Funding Scheme	MC-ITN
Anno di inizio	2009
Periodo (anno-mese-giorno)	2009-01-01   -   2012-12-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	BIOMEDICAL SCIENCES RESEARCH CENTER ALEXANDER FLEMING  Organization address address: Al. Fleming Street 34 city: VARI-ATHENS postcode: 16672 contact info Titolo: Dr. Nome: John Cognome: Strouboulis Email: send email Telefono: -8970232 Fax: -8979888	EL (VARI-ATHENS)	coordinator	712˙929.94
2	FONDAZIONE TELETHON  Organization address address: VIA VARESE 16/B city: ROMA postcode: 185 contact info Titolo: Dr. Nome: Valerio Cognome: Orlando Email: send email Telefono: -501703229 Fax: -501703828	IT (ROMA)	participant	381˙339.20
3	MEDICAL RESEARCH COUNCIL  Organization address address: NORTH STAR AVENUE POLARIS HOUSE city: SWINDON postcode: SN2 1FL contact info Titolo: Dr. Nome: Ana Cognome: Pombo Email: send email Telefono: -83838208 Fax: -83838282	UK (SWINDON)	participant	214˙480.19
4	THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD  Organization address address: University Offices, Wellington Square city: OXFORD postcode: OX1 2JD contact info Titolo: Ms. Nome: Philippa Cognome: Kraftl Email: send email Telefono: -289470 Fax: -289337	UK (OXFORD)	participant	212˙830.19
5	Source Bioscience plc  Organization address address: "ORCHARD PLACE, BUSINESS PARK 1" city: NOTTINGHAM postcode: NG8 6PX contact info Titolo: Mr. Nome: Robert Cognome: Bakewell Email: send email Telefono: 44-115-9739012 Fax: 44-115-9739011	UK (NOTTINGHAM)	participant	207˙880.19
6	LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN  Organization address address: GESCHWISTER SCHOLL PLATZ 1 city: MUENCHEN postcode: 80539 contact info Titolo: Prof. Nome: Axel Cognome: Imhof Email: send email Telefono: -218075460 Fax: +49-89-218075 440	DE (MUENCHEN)	participant	205˙009.20
7	KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW  Organization address address: KLOVENIERSBURGWAL 29 HET TRIPPENHUIS city: AMSTERDAM postcode: 1011 JV contact info Titolo: Mr. Nome: Don Cognome: Van Velzen Email: send email Telefono: -2121799 Fax: -212864	NL (AMSTERDAM)	participant	204˙047.80
8	"BIOMEDICAL RESEARCH FOUNDATION, ACADEMY OF ATHENS"  Organization address address: Soranou Efesiou 4 city: ATHENS postcode: 11527 contact info Titolo: Prof. Nome: Dimitris Cognome: Thanos Email: send email Telefono: -6597424 Fax: -6597779	EL (ATHENS)	participant	161˙483.30

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 Obiettivo del progetto (Objective)

'Cellular differentiation from stem cells to fully functional mature cells is a multi step process executed by complex transcription programs. Once differentiated, cells must faithfully maintain their identity through cellular memory mechanisms. The utilisation of genetic information stored in linear DNA sequence occurs within the three dimensional context of chromatin, chromosomes and the nucleus, all of which contribute to gene regulation mechanisms. The main aim of this ITN is to get a comprehensive view on the mechanisms controling gene expression during cell differentiation by integrating studies on multiple regulatory levels from DNA binding transcription factors through to nuclear organization. We will take a multi-faceted approach addressing the functions of: (i) transcription factors and their co-factors (ii) chromatin domains and histone variants, (iii) epigenetic mechanisms of cellular memory and identity, (iv) global gene interactions in nuclear space and (iv) nuclear territories of gene activity. Genomics approaches will be employed to describe global changes in gene target networks and gene interactions in the nucleus during ES cell differentiation into the hepatic, neuronal and hematopoietic lineages. Proteomics will be employed for the characterization of transcription factor and epigenetic modifying complexes and of the in vivo protein composition of specialized chromatin domains. The research activities of this ITN are organized in the context of a multidisciplinary Training Program, which provides unique opportunities for the training of early stage researchers to address fundamental biological questions with far reaching implications in biotechnology and human health.'

Introduzione (Teaser)

Development of a stem cell to its mature counterpart with a specific identity is controlled by complex transcription networks. An EU project has uncovered new mechanisms that direct the cell differentiation journey.