MEM-S

Bottom-up design and fabrication of industrial bio-inorganic nano-porous membranes with novel functionalities based on principles of protein self-assembly and biomineralization

Coordinatore	UNIVERSITATSMEDIZIN DER JOHANNES GUTENBERG-UNIVERSITAT MAINZ    more  Organization address address: Langenbeckstrasse 1 city: Mainz postcode: 55131 contact info Titolo: Prof. Nome: Werner E.G. Cognome: Müller Email: send email Telefono: +49 6131 3925910 Fax: +49 6131 3925243
Nazionalità Coordinatore	Germany [DE]
Sito del progetto	http://www.eu-mem-s.de
Totale costo	3˙649˙407 €
EC contributo	2˙816˙819 €
Programma	FP7-KBBE Specific Programme "Cooperation": Food, Agriculture and Biotechnology
Code Call	FP7-KBBE-2009-3
Funding Scheme	CP-FP
Anno di inizio	2010
Periodo (anno-mese-giorno)	2010-01-01   -   2012-12-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	UNIVERSITATSMEDIZIN DER JOHANNES GUTENBERG-UNIVERSITAT MAINZ  Organization address address: Langenbeckstrasse 1 city: Mainz postcode: 55131 contact info Titolo: Prof. Nome: Werner E.G. Cognome: Müller Email: send email Telefono: +49 6131 3925910 Fax: +49 6131 3925243	DE (Mainz)	coordinator	630˙634.00
2	UNIVERSITAET FUER BODENKULTUR WIEN  Organization address address: Gregor Mendel Strasse 33 city: WIEN postcode: 1180 contact info Titolo: Prof. Nome: Uwe B. Cognome: Sleytr Email: send email Telefono: +43 1 47654 2201 Fax: +43 1 47891 12	AT (WIEN)	participant	555˙180.00
3	WAGENINGEN UNIVERSITY  Organization address address: DROEVENDAALSESTEEG 4 city: WAGENINGEN postcode: 6708 PB contact info Titolo: Mr. Nome: Jos Cognome: Teunissen Email: send email Telefono: +31 317 485313 Fax: +31 317 484612	NL (WAGENINGEN)	participant	309˙400.00
4	LIONIX BV  Organization address address: HENGELOSESTRAAT 500 city: ENSCHEDE postcode: 7521 AN contact info Titolo: Mr. Nome: Henk Cognome: Leeuwis Email: send email Telefono: +31 53 489 3827 Fax: +31 53 489 3601	NL (ENSCHEDE)	participant	302˙685.00
5	AQUAMARIJN MICRO FILTRATION BV  Organization address address: BERKELKADE 11 city: ZUTPHEN postcode: 7201JE contact info Titolo: Prof. Nome: Cees J.M. Cognome: Van Rijn Email: send email Telefono: -520295 Fax: -8823257	NL (ZUTPHEN)	participant	270˙600.00
6	IWW RHEINISCH WESTFALISCHES INSTITUT FUR WASSERFORSCHUNG GEMEINNUTZIGE GMBH  Organization address address: MORITZSTRASSE 26 city: MULHEIM AN DER RUHR postcode: 45476 contact info Titolo: Mr. Nome: Klaus-Dieter Cognome: Neumann Email: send email Telefono: +49 208 40303 500 Fax: +49 208 40303 80	DE (MULHEIM AN DER RUHR)	participant	252˙600.00
7	UNIVERSITE PIERRE ET MARIE CURIE - PARIS 6  Organization address address: Place Jussieu 4 city: PARIS postcode: 75252 contact info Titolo: Dr. Nome: Elena Cognome: Billi-Rizza Email: send email Telefono: +33 1 44275517 Fax: +33 1 44274769	FR (PARIS)	participant	250˙000.00
8	NanotecMARIN GmbH  Organization address address: Duesbergweg 6 city: Mainz postcode: D 55099 contact info Titolo: Ms. Nome: Jasmine Cognome: Grams Email: send email Telefono: +49 6966 127713 Fax: +49 6966 127712	DE (Mainz)	participant	245˙720.00

Mappa

 Word cloud

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 Obiettivo del progetto (Objective)

'There is strong interest in the development of novel functionalized membranes which can be used as microsieves, as a component of integrated analytical systems, in food processing, drug discovery and diagnostic applications. This project is based on a combination of three break-through technologies, developed by the applicants in the past, with high impact for nano(bio)technological application: (i) the S-layer technology allowing the construction of nanoporous protein lattices, (ii) the biocatalytic formation of inorganic materials by silicatein, a group of unique enzymes capable to catalyze the formation of porous silica from soluble precursors, and (iii) the sol-gel technique for encapsulation (immobilization) of biomolecules serving as biocatalyst or as a component of sensors. The goal of this project is to design and fabricate - based on molecular biology inspired approaches - nano-porous bio-inorganic membranes with novel functionalities for industrial application. These membranes will be formed by S-layer proteins, which are able to assemble to highly ordered structures of defined pore-size, and recombinant silicateins or silicatein fusion proteins. The hydrated silica glass layer formed by silicatein will be used to encase biocatalysts (enzymes) or antibodies against small molecules as sample prep- or sensor components of integrated systems. The innovative type of the functionalized membranes developed in this project thus exploits two principles: (i) protein self-assembly and - and this has not been done before - (ii) enzymatic (silicatein-mediated) deposition of inorganic material used for reinforcement of the membranes as well as for encasing biomolecules, providing the membranes with new functionalities. The new technique will be exploited by three research-based SMEs and the enduser involved in the project, in microfluidics based sample processing and micro-array development, in industrial nanosieves, as well as in sensors in drinking water systems.'

Introduzione (Teaser)

Combining nanotechnology with molecular biology has enabled the development of several breakthrough technologies for wide-ranging industrial applications in food processing, drug discovery and diagnosis. For the first time ever, EU-funded scientists developed bio-functionalised protein membranes for an extensive host of industrial applications.