ER AND METABOLISM

Oxidative protein folding and pathogenesis of metabolic disorders

Coordinatore	THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE    more  Organization address address: The Old Schools, Trinity Lane city: CAMBRIDGE postcode: CB2 1TN contact info Titolo: Ms. Nome: Renata Cognome: Schaeffer Email: send email Telefono: +44 1223 333543 Fax: +44 1223 332988
Nazionalità Coordinatore	United Kingdom [UK]
Totale costo	100˙000 €
EC contributo	100˙000 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2010-RG
Funding Scheme	MC-IRG
Anno di inizio	2011
Periodo (anno-mese-giorno)	2011-03-01   -   2015-02-28

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE  Organization address address: The Old Schools, Trinity Lane city: CAMBRIDGE postcode: CB2 1TN contact info Titolo: Ms. Nome: Renata Cognome: Schaeffer Email: send email Telefono: +44 1223 333543 Fax: +44 1223 332988	UK (CAMBRIDGE)	coordinator	100˙000.00

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 Obiettivo del progetto (Objective)

'Endoplasmic reticulum (ER) oxidation 1 (ERO1) trasfers disulfide bonds to protein disulfide isomerase (PDI) and is essential for oxidative protein folding in simple eukaryotes such as yeast and worms. Higher eucaryotes have alternative pathways for disulfide bond formation (Zito et al., 2010). Recently we have discovered that the ER localized peroxiredoxin 4 (PRDX4) is able to couple use of hydroperoxides for oxidative protein folding, independently of ERO1 (Zito et al., 2010b). Hydrogen peroxide production is coupled both to nutrient assimilation and to insulin signaling whereas disulfide bond formation is limiting to the production of important signaling molecules such as insulin itself (in nutrient and insulin-responsive beta cells) and adipokines (in insulin responsive adipose tissue). The aim of this proposal is to evaluate, in cultured cells and intact mice, the impact of PRDX4 and ERO1 activity on the biosynthesis and the functional state of insulin and adypokines and consequently on intermediary metabolism. Recent evidence indicates that disulfide bond formation can be manipulated with chemical probes (Blais et al., 2010). Therefore the proposed study may bring to light novel targets for pharmacological intervention in diabetes and insulin resistance states.'