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PHOCNOSIS SIGNED

Advanced nanophotonic point-of-care analysis device for fast and early diagnosis of cardiovascular diseases

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

PHOCNOSIS project word cloud

Explore the words cloud of the PHOCNOSIS project. It provides you a very rough idea of what is the project "PHOCNOSIS" about.

sensing cvd separation ultra portable disposable suitable diseases sensitive preclinical blood micro reducing compact consequent technological 1000x device special diagnosis industrial envisaged 3000 nanophotonic clinical point detected ng volume concentrated multiple deployment cardiovascular detection rates explore screening obtain label minutes involvement treatments first programs biomarkers concentration survival lower poct nanotechnology final below small mu biochips technique complexity cardiac commercialisation mass phocnosis academic purification fast significantly care paid lt validation limit nanofluidic handheld combined envisaging free

Project "PHOCNOSIS" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITAT POLITECNICA DE VALENCIA Organization address address: CAMINO DE VERA SN EDIFICIO 3A city: VALENCIA postcode: 46022 website: www.upv.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Spain [ES]
Project website	https://web.archive.org/web/20180412122207/https://phocnosis.eu/
Total cost	4˙146˙163 €
EC max contribution	3˙593˙962 € (87%)
Programme	1. H2020-EU.3.1.3. (Treating and managing disease)
Code Call	H2020-PHC-2014-two-stage
Funding Scheme	RIA
Starting year	2015
Duration (year-month-day)	from 2015-09-01 to 2019-02-28

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITAT POLITECNICA DE VALENCIA UNIVERSITAT POLITECNICA DE VALENCIA Organization address address: CAMINO DE VERA SN EDIFICIO 3A city: VALENCIA postcode: 46022 website: www.upv.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (VALENCIA)	coordinator	1˙097˙891.00
2	UNIVERSITEIT TWENTE UNIVERSITEIT TWENTE Organization address address: DRIENERLOLAAN 5 city: ENSCHEDE postcode: 7522 NB website: www.utwente.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (ENSCHEDE)	participant	423˙731.00
3	FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V. FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V. Organization address address: HANSASTRASSE 27C city: MUNCHEN postcode: 80686 website: www.fraunhofer.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (MUNCHEN)	participant	409˙050.00
4	AALBORG UNIVERSITET AALBORG UNIVERSITET Organization address address: FREDRIK BAJERS VEJ 7K city: AALBORG postcode: 9220 website: www.aau.dk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (AALBORG)	participant	344˙915.00
5	CDA GMBH CDA GMBH Organization address address: AM MITTELRAIN 11 city: SUHL OT ALBRECHTS postcode: 98529 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (SUHL OT ALBRECHTS)	participant	336˙537.00
6	ST GEORGE'S HOSPITAL MEDICAL SCHOOL ST GEORGE'S HOSPITAL MEDICAL SCHOOL Organization address address: CRANMER TERRACE city: LONDON postcode: SW17 0RE website: http://www.sgul.ac.uk/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	participant	315˙937.00
7	EV GROUP E. THALLNER GMBH EV GROUP E. THALLNER GMBH Organization address address: DI ERICH THALLNER STRASSE 1 city: ST FLORIAN AM INN postcode: 4782 website: www.evgroup.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	AT (ST FLORIAN AM INN)	participant	257˙650.00
8	BIONOS BIOTECH SL BIONOS BIOTECH SL Organization address address: BULEV SUR S/N - BIOPOLO LA FE EDIFICIO TORRE A HO city: VALENCIA postcode: 46029 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (VALENCIA)	participant	227˙000.00
9	DB VENTURE BUILDER SL DB VENTURE BUILDER SL Organization address address: CALLE ANTONIO SUAREZ 27 1 1 city: VALENCIA postcode: 46021 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (VALENCIA)	participant	131˙515.00
10	GENERA BIOTECH SL GENERA BIOTECH SL Organization address address: C/ CATEDRATICO AGUSTIN ESCARDINO 9 city: PATERNA VALENCIA postcode: 46980 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (PATERNA VALENCIA)	participant	49˙734.00
11	ART OF TECHNOLOGY AG ART OF TECHNOLOGY AG Organization address address: TECHNOPARKSTRASSE 1 city: ZURICH postcode: 8005 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (ZURICH)	participant	0.00

Map

Project objective

The PHOCNOSIS project aims at the development and the preclinical validation of a nanotechnology-based handheld point-of-care testing (POCT) analysis device for its application in the early diagnosis of cardiovascular diseases (CVD). The diagnosis will be carried out by means of the fast (<10 minutes), ultra-sensitive (<1 ng/L) and label-free detection of multiple cardiac biomarkers, using a small volume of whole blood (<100 μL). This POCT analysis device will significantly help in the implementation of mass screening programs, with the consequent impact on clinical management, reducing also costs of treatments, and increasing survival rates. The PHOCNOSIS analysis device will be based on two state-of-the-art technological elements in order to obtain a compact and highly sensitive final device. First, an integrated micro-/nanofluidic system will be used for biomarkers separation, purification and concentration, targeting an effective concentration increase by a factor greater than 1000x for the targeted biomarkers. Then, the concentrated biomarkers will be detected using a novel nanophotonic-based sensing technique, envisaging a final combined detection limit below 1 ng/L. This novel sensing technique allows us to obtain systems which are low-cost, compact and with a lower complexity, thus making them suitable for the development of portable devices for POCT. The PHOCNOSIS project will target the deployment of disposable biochips with an envisaged cost below €3 to be used in a handheld analysis device with an envisaged cost below €3000. Special attention will be paid within the PHOCNOSIS project to explore the potential deployment and commercialisation of the analysis device, by means of the involvement of relevant academic and industrial partners, as well as end users.

Publications

List of publications.
year	authors and title	journal	last update
2019	L. Torrijos-MorÃ¡n, J. GarcÃa-RupÃ©rez Single-channel bimodal interferometric sensor using subwavelength structures published pages: 8168, ISSN: 1094-4087, DOI: 10.1364/oe.27.008168	Optics Express 27/6	2019-09-09
2017	Odete GonÃ§alves, Scott Snider, Ruben Zadoyan, Quoc-Thang Nguyen, Henrik Vorum, Steffen B. Petersen, Maria Teresa Neves-Petersen Novel microfabrication stage allowing for one-photon and multi-photon light assisted molecular immobilization and for multi-photon microscope published pages: 100790F, ISSN: , DOI: 10.1117/12.2250567	Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications IX	2019-09-09
2018	V.A. Papadimitriou, L.I. Segerink, A. van den Berg, J.C.T. Eijkel 3D capillary stop valves for versatile patterning inside microfluidic chips published pages: 232-238, ISSN: 0003-2670, DOI: 10.1016/j.aca.2017.11.055	Analytica Chimica Acta 1000	2019-09-09
2019	Jad Sabek, Paula MartÃnez-PÃ©rez, Jaime GarcÃa-RupÃ©rez Computational binding study of cardiac troponin I antibody towards cardiac versus skeletal troponin I published pages: 147-151, ISSN: 1476-9271, DOI: 10.1016/j.compbiolchem.2019.04.002	Computational Biology and Chemistry 80	2019-09-09
2019	Jad Sabek, Luis Torrijos-MorÃ¡n, Amadeu Griol, Zeneida DÃaz Betancor, MarÃa-JosÃ© BaÃ±uls Polo, Ãngel Maquieira, Jaime GarcÃa-RupÃ©rez Real Time Monitoring of a UV Light-Assisted Biofunctionalization Protocol Using a Nanophotonic Biosensor published pages: 6, ISSN: 2079-6374, DOI: 10.3390/bios9010006	Biosensors 9/1	2019-09-09
2018	Rafael Alonso, Pilar JimÃ©nez-Meneses, Jaime GarcÃa-RupÃ©rez, MarÃa-JosÃ© BaÃ±uls, Ãngel Maquieira Thiolâ€“ene click chemistry towards easy microarraying of half-antibodies published pages: 6144-6147, ISSN: 1359-7345, DOI: 10.1039/c8cc01369a	Chemical Communications 54/48	2019-09-09
2019	MarÃa-JosÃ© BaÃ±uls, Miguel Ãngel GonzÃ¡lez-MartÃnez, Jad Sabek, Jaime GarcÃa-RupÃ©rez, Ãngel Maquieira Thiol-click photochemistry for surface functionalization applied to optical biosensing published pages: 103-113, ISSN: 0003-2670, DOI: 10.1016/j.aca.2019.01.055	Analytica Chimica Acta 1060	2019-09-09

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