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NABBA

Design and development of advanced NAnomedicines to overcome Biological BArriers and to treat severe diseases

Total Cost €

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EC-Contrib. €

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Partnership

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Outcomes and
results

NABBA project word cloud

Explore the words cloud of the NABBA project. It provides you a very rough idea of what is the project "NABBA" about.

characterization recombinant assembly types nanoparticles proteins form stage emphasis innovative gene esrs antibodies chemistry internationally mechanisms platforms nps shielded interests either nanomedicine probes programs benefit academia drugs crossing pharmacokinetics cutting opportunity molecular strategies give solution network ruling techniques peculiar manufacturing chemical biological nanobiotechnology biomedical participation synthetic vehicles expertises pathological acquainted synthesis companies limiting expedients edge loading diagnostic nabba proof nano functionalization technologies technological possibility train biodistribution circulation sophisticated cooperation physiological many scientific pharmacological pharmaceutics devoted industries therapeutics np industrial barriers detection therapeutic esr scientists cross conventional

Project "NABBA" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITA' DEGLI STUDI DI MILANO-BICOCCA Organization address address: PIAZZA DELL'ATENEO NUOVO 1 city: MILANO postcode: 20126 website: www.unimib.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Italy [IT]
Project website	http://www.nabbaproject.eu
Total cost	2˙851˙274 €
EC max contribution	2˙851˙274 € (100%)
Programme	1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
Code Call	H2020-MSCA-ITN-2014
Funding Scheme	MSCA-ITN-ETN
Starting year	2015
Duration (year-month-day)	from 2015-01-01 to 2019-02-28

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITA' DEGLI STUDI DI MILANO-BICOCCA UNIVERSITA' DEGLI STUDI DI MILANO-BICOCCA Organization address address: PIAZZA DELL'ATENEO NUOVO 1 city: MILANO postcode: 20126 website: www.unimib.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (MILANO)	coordinator	917˙551.00
2	CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS Organization address address: RUE MICHEL ANGE 3 city: PARIS postcode: 75794 website: www.cnrs.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	participant	525˙751.00
3	HELMHOLTZ-ZENTRUM FUR INFEKTIONSFORSCHUNG GMBH HELMHOLTZ-ZENTRUM FUR INFEKTIONSFORSCHUNG GMBH Organization address address: INHOFFENSTRASSE 7 city: BRAUNSCHWEIG postcode: 38124 website: www.helmholtz-hzi.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (BRAUNSCHWEIG)	participant	498˙432.00
4	UNIVERSIDAD DE SANTIAGO DE COMPOSTELA UNIVERSIDAD DE SANTIAGO DE COMPOSTELA Organization address address: COLEXIO DE SAN XEROME PRAZA DO OBRADOIRO S/N city: SANTIAGO DE COMPOSTELA postcode: 15782 website: http://www.usc.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (SANTIAGO DE COMPOSTELA)	participant	495˙745.00
5	UNIVERSITEIT UTRECHT UNIVERSITEIT UTRECHT Organization address address: HEIDELBERGLAAN 8 city: UTRECHT postcode: 3584 CS website: www.uu.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (UTRECHT)	participant	255˙374.00
6	ENVIROINVEST KORNYEZETVEDELMI ES BIOTECHNOLOGIAI ZARTKORUEN MUKODO RESZVENYTARASASAG ENVIROINVEST KORNYEZETVEDELMI ES BIOTECHNOLOGIAI ZARTKORUEN MUKODO RESZVENYTARASASAG Organization address address: KERTVAROS UTCA 2 city: PECS postcode: 7632 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	HU (PECS)	participant	158˙418.00
7	BIOTALENTUM TUDASFEJLESZTO KFT BIOTALENTUM TUDASFEJLESZTO KFT Organization address address: AULICH LAJOS UTCA 26 city: GOEDOELLO postcode: 2100 website: www.biotalentum.hu contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	HU (GOEDOELLO)	partner	0.00
8	EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH Organization address address: Raemistrasse 101 city: ZUERICH postcode: 8092 website: https://www.ethz.ch/de.html contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (ZUERICH)	partner	0.00
9	NOVARTIS PHARMA AG NOVARTIS PHARMA AG Organization address address: LICHTSTRASSE 35 city: BASEL postcode: 4056 website: www.novartis.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (BASEL)	partner	0.00
10	SYLENTIS SAU SYLENTIS SAU Organization address address: PLAZA DESCUBRIDOR DIEGO DE ORDAS 3 city: Madrid postcode: 28003 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (Madrid)	partner	0.00

Map

Project objective

Many therapeutic targets are shielded behind biological barriers, limiting the possibility to reach them with conventional drugs or diagnostic probes. Biological barriers are even more problematic for most biological pharmaceutics, such as recombinant proteins, antibodies and gene therapeutics. The most promising solution to this challenge is the use of nano-vehicles for specific targeting and delivery. The aim of NABBA is to form European early stage researchers (ESR) with cutting-edge scientific knowledge in the field of nanoparticles (NP) for biomedical application, able to cross biological barriers. For this aim the project will train ESRs, focusing on key aspects of nanobiotechnology: (i) design and chemical synthesis of different types of NPs, (ii) related techniques of detection and characterization, (iii) strategies of loading, targeting and delivery of drugs or diagnostic probes; (iv) proof of principle of pharmacological activity including pharmacokinetics and biodistribution. As a peculiar feature of NABBA, strong emphasis will be devoted to molecular mechanisms ruling biological barriers under physiological and pathological conditions, in order to develop novel nano-technological expedients for their crossing. Strong emphasis will be devoted to advanced chemistry issues, enabling new synthetic strategies either for NP assembly or functionalization. Different biological barriers will be addressed. ESRs will strongly benefit from a network of internationally recognized scientists in the field of chemistry, nanobiotechnology and nanomedicine, and the participation of companies with relevant interests and expertises in the field. The planned cooperation programs between Academia and Industries will allow the circulation of ESRs and this will give them the opportunity for to get acquainted with the most advanced research in the field, the most sophisticated technologies and the most advanced Industrial manufacturing platforms and innovative strategies.

Deliverables

List of deliverables.
Website	Websites, patent fillings, videos etc.	2019-09-06 10:41:36
ESRs representative	Other	2019-09-06 10:41:36

Take a look to the deliverables list in detail: detailed list of NABBA deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2018	Duy-Khiet Ho, Ana Costa, Chiara De Rossi, Cristiane de Souza Carvalho-Wodarz, Brigitta Loretz, Claus-Michael Lehr Polysaccharide Submicrocarrier for Improved Pulmonary Delivery of Poorly Soluble Anti-infective Ciprofloxacin: Preparation, Characterization, and Influence of Size on Cellular Uptake published pages: 1081-1096, ISSN: 1543-8384, DOI: 10.1021/acs.molpharmaceut.7b00967	Molecular Pharmaceutics 15/3	2019-09-06
2018	Alysia Cox, Patrizia Andreozzi, Roberta Dal Magro, Fabio Fiordaliso, Alessandro Corbelli, Laura Talamini, Clizia Chinello, Francesca Raimondo, Fulvio Magni, Maria Tringali, Silke Krol, Paulo Jacob Silva, Francesco Stellacci, Massimo Masserini, Francesca Re Evolution of Nanoparticle Protein Corona across the Bloodâ€“Brain Barrier published pages: 7292-7300, ISSN: 1936-0851, DOI: 10.1021/acsnano.8b03500	ACS Nano 12/7	2019-09-06
2016	Anshuman Dasgupta, Mengjiao Liu, Tarun Ojha, Gert Storm, Fabian Kiessling, Twan Lammers Ultrasound-mediated drug delivery to the brain: principles, progress and prospects published pages: 41-48, ISSN: 1740-6749, DOI: 10.1016/j.ddtec.2016.07.007	Drug Discovery Today: Technologies 20	2019-09-06
2018	Josu Andrieu, Francesca Re, Laura Russo, Francesco Nicotra Phage-displayed peptides targeting specific tissues and organs published pages: 1-11, ISSN: 1061-186X, DOI: 10.1080/1061186x.2018.1531419	Journal of Drug Targeting	2019-09-06
2017	Irene Santalices, Andrea Gonella, Dolores Torres, MarÃa JosÃ© Alonso Advances on the formulation of proteins using nanotechnologies published pages: 155-180, ISSN: 1773-2247, DOI: 10.1016/j.jddst.2017.06.018	Journal of Drug Delivery Science and Technology 42	2019-09-06
2018	Daniele Vinciguerra, Johanna Tran, Julien Nicolas Telechelic polymers from reversible-deactivation radical polymerization for biomedical applications published pages: 228-240, ISSN: 1359-7345, DOI: 10.1039/c7cc08544c	Chemical Communications 54/3	2019-09-06
2018	Duy-Khiet Ho, Sarah Frisch, Alexander Biehl, Emmanuel Terriac, Chiara De Rossi, Konrad Schwarzkopf, Franziska LautenschlÃ¤ger, Brigitta Loretz, Xabier Murgia, Claus-Michael Lehr Farnesylated Glycol Chitosan as a Platform for Drug Delivery: Synthesis, Characterization, and Investigation of Mucusâ€“Particle Interactions published pages: 3489-3501, ISSN: 1525-7797, DOI: 10.1021/acs.biomac.8b00795	Biomacromolecules 19/8	2019-09-06
2018	Hanzey Yasar, Duy-Khiet Ho, Chiara De Rossi, Jennifer Herrmann, Sarah Gordon, Brigitta Loretz, Claus-Michael Lehr Starch-Chitosan Polyplexes: A Versatile Carrier System for Anti-Infectives and Gene Delivery published pages: 252, ISSN: 2073-4360, DOI: 10.3390/polym10030252	Polymers 10/3	2019-09-06
2018	Gianpiero Lazzari, ValÃ©rie Nicolas, Michiya Matsusaki, Mitsuru Akashi, Patrick Couvreur, Simona Mura Multicellular spheroid based on a triple co-culture: A novel 3D model to mimic pancreatic tumor complexity published pages: 296-307, ISSN: 1742-7061, DOI: 10.1016/j.actbio.2018.08.008	Acta Biomaterialia 78	2019-09-06
2018	Daniele Vinciguerra, StÃ©phanie Denis, Julie Mougin, Merel Jacobs, Yohann Guillaneuf, Simona Mura, Patrick Couvreur, Julien Nicolas A facile route to heterotelechelic polymer prodrug nanoparticles for imaging, drug delivery and combination therapy published pages: 425-438, ISSN: 0168-3659, DOI: 10.1016/j.jconrel.2018.08.013	Journal of Controlled Release 286	2019-09-06
2017	Qingxue Sun, Tarun Ojha, Fabian Kiessling, Twan Lammers, Yang Shi Enhancing Tumor Penetration of Nanomedicines published pages: 1449-1459, ISSN: 1525-7797, DOI: 10.1021/acs.biomac.7b00068	Biomacromolecules 18/5	2019-09-06
2016	Okan Tezcan, Tarun Ojha, Gert Storm, Fabian Kiessling, Twan Lammers Targeting cellular and microenvironmental multidrug resistance published pages: 1199-1202, ISSN: 1742-5247, DOI: 10.1080/17425247.2016.1214570	Expert Opinion on Drug Delivery 13/9	2019-09-06
2016	Benjamin Theek, Maike Baues, Tarun Ojha, Diana MÃ¶ckel, Seena Koyadan Veettil, Julia Steitz, Louis van Bloois, Gert Storm, Fabian Kiessling, Twan Lammers Sonoporation enhances liposome accumulation and penetration in tumors with low EPR published pages: 77-85, ISSN: 0168-3659, DOI: 10.1016/j.jconrel.2016.02.021	Journal of Controlled Release 231	2019-09-06
2016	Miriam Colombo, Luisa Fiandra, Giulia Alessio, Serena Mazzucchelli, Manuela Nebuloni, Clara De Palma, Karsten Kantner, Beatriz Pelaz, Rany Rotem, Fabio Corsi, Wolfgang J. Parak, Davide Prosperi Tumour homing and therapeutic effect of colloidal nanoparticles depend on the number of attached antibodies published pages: 13818, ISSN: 2041-1723, DOI: 10.1038/ncomms13818	Nature Communications 7	2019-09-06
2017	Tarun Ojha, Vertika Pathak, Yang Shi, Wim E. Hennink, Chrit T.W. Moonen, Gert Storm, Fabian Kiessling, Twan Lammers Pharmacological and physical vessel modulation strategies to improve EPR-mediated drug targeting to tumors published pages: , ISSN: 0169-409X, DOI: 10.1016/j.addr.2017.07.007	Advanced Drug Delivery Reviews	2019-09-06

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