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MEDILIGHT

Miniaturized smart system for light stimulation and monitoring of wound healing

Total Cost €

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EC-Contrib. €

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Partnership

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Outcomes and
results

MEDILIGHT project word cloud

Explore the words cloud of the MEDILIGHT project. It provides you a very rough idea of what is the project "MEDILIGHT" about.

comfort controller fibroblasts soft annually waveguide device technologies history explored acquisition optical 450 sensors health therapy wounds fabrication professional programs interconnected multiple care proven light self 750nm disposable predominantly plug medical blood parts visible 495nm induces edge monitor respective transmission algorithms leds waveguides compliant layers electronic spatial monitored keratinocytes vivo hygiene interconnection rechargeable loops pcb schemes analog patients heterogeneous billion exposure skin battery mechanically backed oxygen red feedback 620 surface electronics professionals photodiode deeper approximately stretchable data combining temperature structures containing module healing blue antibacterial wound vitro spectrum consist optimized integration electrical dressing monitoring therapeutic chronic coupling million resolution burden animal temporal embedding status smart

Project "MEDILIGHT" data sheet

The following table provides information about the project.

Coordinator	TECHNISCHE UNIVERSITAT BERLIN Organization address address: STRASSE DES 17 JUNI 135 city: BERLIN postcode: 10623 website: www.tu-berlin.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Germany [DE]
Project website	http://www.medilight-project.eu
Total cost	2˙988˙034 €
EC max contribution	2˙475˙310 € (83%)
Programme	1. H2020-EU.2.1.1.1. (A new generation of components and systems: Engineering of advanced embedded and energy and resource efficient components and systems)
Code Call	H2020-ICT-2014-1
Funding Scheme	RIA
Starting year	2015
Duration (year-month-day)	from 2015-02-01 to 2018-07-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	TECHNISCHE UNIVERSITAT BERLIN TECHNISCHE UNIVERSITAT BERLIN Organization address address: STRASSE DES 17 JUNI 135 city: BERLIN postcode: 10623 website: www.tu-berlin.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (BERLIN)	coordinator	587˙500.00
2	URGO RECHERCHE INNOVATION ET DEVELOPPEMENT URGO RECHERCHE INNOVATION ET DEVELOPPEMENT Organization address address: 42 RUE DE LONGVIC city: CHENOVE postcode: 21300 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (CHENOVE)	participant	504˙308.00
3	MICROSEMI SEMICONDUCTOR LIMITED MICROSEMI SEMICONDUCTOR LIMITED Organization address address: PHASE 2 CASTLEGATE BUSINESS PARK city: GWENT postcode: NP26 5YW website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (GWENT)	participant	410˙000.00
4	RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG Organization address address: SEMINARSTRASSE 2 city: HEIDELBERG postcode: 69117 website: www.uni-heidelberg.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (HEIDELBERG)	participant	401˙218.00
5	SIGNALGENERIX LIMITED SIGNALGENERIX LIMITED Organization address address: GRIGORI AFXENTIOU 23C MESA GEITONIA city: LIMASSOL postcode: 4003 website: www.signalgenerix.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CY (LIMASSOL)	participant	324˙375.00
6	AMIRES SRO AMIRES SRO Organization address address: STAVITELSKA 1099/6 city: PRAHA 6 postcode: 160 00 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CZ (PRAHA 6)	participant	151˙750.00
7	LABORATOIRES URGO LABORATOIRES URGO Organization address address: 42 rue de Longvic city: Chenove postcode: 21300 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (Chenove)	participant	96˙159.00
8	CSEM CENTRE SUISSE D'ELECTRONIQUE ET DE MICROTECHNIQUE SA - RECHERCHE ET DEVELOPPEMENT CSEM CENTRE SUISSE D'ELECTRONIQUE ET DE MICROTECHNIQUE SA - RECHERCHE ET DEVELOPPEMENT Organization address address: RUE JAQUET DROZ 1 city: NEUCHATEL postcode: 2000 website: www.csem.ch contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (NEUCHATEL)	participant	0.00

Map

Project objective

Chronic wounds represent a significant burden to patients, health care professionals, and health care systems, affecting over 40 million patients and creating costs of approximately 40 billion € annually. Goal of the project is the fabrication of a medical device for professional wound care. The device will use recently proven therapeutic effects of visible light to enhance the self-healing process and monitor the status and history of the wound during therapy. Light exposure in the red part of the spectrum (620-750nm) induces growth of keratinocytes and fibroblasts in deeper layers of the skin. The blue part of the spectrum (450–495nm) is known to have antibacterial effects predominantly at the surface layers of the skin. In order to be compliant with hygiene requirements the system will consist of two parts: 1. a disposable wound dressing with embedded optical waveguides and integrated sensors for the delivery of light and monitoring (temperature and blood oxygen) of the wound. 2. a soft and compliant electronic module for multiple use containing LEDs, a photodiode, a controller, analog data acquisition, a rechargeable battery, and a data transmission unit. Both parts of the device will be interconnected by a mechanically robust plug, enabling a low loss coupling of light into the waveguide structures and electrical interconnection to the sensors. The status of the wound will be monitored with temporal and low level spatial resolution. The electronic module will be optimized for functionality and user comfort, combining leading edge heterogeneous integration technologies (PCB embedding) and stretchable electronics approaches. The detailed effects of light-exposure schemes will be explored and backed by in-vitro and in-vivo animal studies. Results will be used to develop smart algorithms and implement it into respective programs and feedback loops of the device.

Deliverables

List of deliverables.
Webpage of the project	Websites, patent fillings, videos etc.	2019-02-26 10:34:26
Development of the preliminary exploitation, dissemination and Communication strategy and the project brochure	Documents, reports	2019-02-26 10:34:26

Take a look to the deliverables list in detail: detailed list of MEDILIGHT deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2015	Kuch, N. Optimization of Keratinocyte-Fibroblast Co-Cultures published pages: , ISSN: , DOI:		2019-05-30
2015	Klapczynski, A. Effects of blue light irradiation on human dermal fibroblasts published pages: , ISSN: , DOI:		2019-05-30
2017	Enzlein, T. Influence of light on adipose derived stem cells published pages: , ISSN: , DOI:		2019-05-30
2016	Anja Becker, Anna Klapczynski, Natalia Kuch, Fabiola Arpino, Katja Simon-Keller, Carolina De La Torre, Carsten Sticht, Frank A. van Abeelen, Gerrit Oversluizen, Norbert Gretz Gene expression profiling reveals aryl hydrocarbon receptor as a possible target for photobiomodulation when using blue light published pages: 33847, ISSN: 2045-2322, DOI: 10.1038/srep33847	Scientific Reports 6	2019-05-30
2016	Kuch, N. Co-cultures of Fibroblasts and Keratinocytes under the influence of blue light published pages: , ISSN: , DOI:		2019-05-30
2015	Distler, E. Influence of blue LED irradiation on human melanoma cells published pages: , ISSN: , DOI:		2019-05-30
2017	Schreiner, S. Influence of Red Light Irradiation on Melanoma Cells published pages: , ISSN: , DOI:		2019-05-30
2017	Becker, A. Influence of photobiomodulation with blue light on the metabolism, proliferation and gene expression of human keratinocytes published pages: , ISSN: , DOI:		2019-05-30
2018	HÃ¼llen, A. Influence of Blue Light Irradiation on Bacteria using Escherichia coli as a model organism published pages: , ISSN: , DOI:		2019-05-30
2017	Schreiner, S. Effects of Blue Light Irradiation on Human Melanoma Cells published pages: , ISSN: , DOI:		2019-05-30
2018	Arif ul Maula Khan, Angelo Torelli, Ivo Wolf, Norbert Gretz AutoCellSeg: robust automatic colony forming unit (CFU)/cell analysis using adaptive image segmentation and easy-to-use post-editing techniques published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-24916-9	Scientific Reports 8/1	2019-05-30

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The information about "MEDILIGHT" are provided by the European Opendata Portal: CORDIS opendata.

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