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BIOLOCHANICS SIGNED

Localization in biomechanics and mechanobiology of aneurysms: Towards personalized medicine

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

BIOLOCHANICS project word cloud

Explore the words cloud of the BIOLOCHANICS project. It provides you a very rough idea of what is the project "BIOLOCHANICS" about.

mechanics scientific patient evolutions internal aneurysms material possibly distributions predictions infuse full soft damage kills preceding tissues occurs theory enriched saint clinical scales optical cell permit strength phenomenon surgery usa degraded retrospective aorta progression tissue treatment exceeds occurring genetic mechanobiology models reveals implementing aortic extended stages vivo stress localization etienne computational repair university first mechanisms aa estimations achievements relates nonlocal sport thanks biomechanics continuum length structure orthopaedics characterizing human biology pharmacologic experiments persons pharmacological rupture patients interventional biolochanics prediction local calibrating hospital localized safety rat oncology risk named performed mice wall

Project "BIOLOCHANICS" data sheet

The following table provides information about the project.

Coordinator	ASSOCIATION POUR LA RECHERCHE ET LE DEVELOPPEMENT DES METHODES ET PROCESSUS INDUSTRIELS Organization address address: BOULEVARD SAINT MICHEL 60 city: PARIS postcode: 75272 website: www.armines.net contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	France [FR]
Total cost	1˙999˙396 €
EC max contribution	1˙999˙396 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2014-CoG
Funding Scheme	ERC-COG
Starting year	2015
Duration (year-month-day)	from 2015-05-01 to 2020-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	ASSOCIATION POUR LA RECHERCHE ET LE DEVELOPPEMENT DES METHODES ET PROCESSUS INDUSTRIELS ASSOCIATION POUR LA RECHERCHE ET LE DEVELOPPEMENT DES METHODES ET PROCESSUS INDUSTRIELS Organization address address: BOULEVARD SAINT MICHEL 60 city: PARIS postcode: 75272 website: www.armines.net contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	coordinator	1˙920˙003.00
2	CENTRE HOSPITALIER UNIVERSITAIRE SAINT ETIENNE - CHU CENTRE HOSPITALIER UNIVERSITAIRE SAINT ETIENNE - CHU Organization address address: n.a. city: SAINT ETIENNE postcode: 42055 website: www.chu-st-etienne.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (SAINT ETIENNE)	participant	79˙393.00

Map

Project objective

Rupture of Aortic Aneurysms (AA), which kills more than 30 000 persons every year in Europe and the USA, is a complex phenomenon that occurs when the wall stress exceeds the local strength of the aorta due to degraded properties of the tissue. The state of the art in AA biomechanics and mechanobiology reveals that major scientific challenges still have to be addressed to permit patient-specific computational predictions of AA rupture and enable localized repair of the structure with targeted pharmacologic treatment. A first challenge relates to ensuring an objective prediction of localized mechanisms preceding rupture. A second challenge relates to modelling the patient-specific evolutions of material properties leading to the localized mechanisms preceding rupture. Addressing these challenges is the aim of the BIOLOCHANICS proposal. We will take into account internal length-scales controlling localization mechanisms preceding AA rupture by implementing an enriched, also named nonlocal, continuum damage theory in the computational models of AA biomechanics and mechanobiology. We will also develop very advanced experiments, based on full-field optical measurements, aimed at characterizing localization mechanisms occurring in aortic tissues and at identifying local distributions of material properties at different stages of AA progression. A first in vivo application will be performed on genetic and pharmacological models of mice and rat AA. Eventually, a retrospective clinical study involving more than 100 patients at the Saint-Etienne University hospital will permit calibrating estimations of AA rupture risk thanks to our novel approaches and infuse them into future clinical practice. Through the achievements of BIOLOCHANICS, nonlocal mechanics will be possibly extended to other soft tissues for applications in orthopaedics, oncology, sport biomechanics, interventional surgery, human safety, cell biology, etc.

Publications

List of publications.
year	authors and title	journal	last update
2017	Witold Krasny, Claire Morin, HÃ©lÃ¨ne Magoariec, StÃ©phane Avril A comprehensive study of layer-specific morphological changes in the microstructure of carotid arteries under uniaxial load published pages: 342-351, ISSN: 1742-7061, DOI: 10.1016/j.actbio.2017.04.033	Acta Biomaterialia 57	2020-03-23
2016	Ambroise Duprey, Olfa Trabelsi, Marco Vola, Jean-Pierre Favre, StÃ©phane Avril Biaxial rupture properties of ascending thoracic aortic aneurysms published pages: 273-285, ISSN: 1742-7061, DOI: 10.1016/j.actbio.2016.06.028	Acta Biomaterialia 42	2020-03-23
2017	S. Jamaleddin Mousavi, StÃ©phane Avril Patient-specific stress analyses in the ascending thoracic aorta using a finite-element implementation of the constrained mixture theory published pages: 1765-1777, ISSN: 1617-7959, DOI: 10.1007/s10237-017-0918-2	Biomechanics and Modeling in Mechanobiology 16/5	2020-03-23
2018	O. Trabelsi, M. Gutierrez, S. Farzaneh, A. Duprey, S. Avril A non-invasive methodology for ATAA rupture risk estimation published pages: 119-126, ISSN: 0021-9290, DOI: 10.1016/j.jbiomech.2017.11.012	Journal of Biomechanics 66	2020-03-23
2018	Witold Krasny, HÃ©lÃ¨ne Magoariec, Claire Morin, StÃ©phane Avril Kinematics of collagen fibers in carotid arteries under tension-inflation loading published pages: 718-726, ISSN: 1751-6161, DOI: 10.1016/j.jmbbm.2017.08.014	Journal of the Mechanical Behavior of Biomedical Materials 77	2020-03-23
2017	StÃ©phane Avril Hyperelasticity of Soft Tissues and Related Inverse Problems published pages: 37-66, ISSN: , DOI: 10.1007/978-3-319-45071-1_2		2020-03-23
2017	F. Condemi, S. Campisi, M. Viallon, T. Troalen, G. Xuexin, A. J. Barker, M. Markl, P. Croisille, O. Trabelsi, C. Cavinato, A. Duprey, S. Avril Fluid- and Biomechanical Analysis of Ascending Thoracic Aorta Aneurysm with Concomitant Aortic Insufficiency published pages: 2921-2932, ISSN: 0090-6964, DOI: 10.1007/s10439-017-1913-6	Annals of Biomedical Engineering 45/12	2020-03-23
2016	Matthew R. Bersi, Chiara Bellini, Paolo Di Achille, Jay D. Humphrey, Katia Genovese, StÃ©phane Avril Novel Methodology for Characterizing Regional Variations in the Material Properties of Murine Aortas published pages: 71005, ISSN: 0148-0731, DOI: 10.1115/1.4033674	Journal of Biomechanical Engineering 138/7	2020-03-23
2017	S. Jamaleddin Mousavi, Solmaz Farzaneh, StÃ©phane Avril Computational predictions of damage propagation preceding dissection of ascending thoracic aortic aneurysms published pages: e2944, ISSN: 2040-7939, DOI: 10.1002/cnm.2944	International Journal for Numerical Methods in Biomedical Engineering	2020-03-23
2018	Francesca Condemi, Salvatore Campisi, Magalie Viallon, Pierre Croisille, Jean-FranÃ§ois Fuzelier, StÃ©phane Avril Ascending thoracic aorta aneurysm repair induces positive hemodynamic outcomes in a patient with unchanged bicuspid aortic valve published pages: 145-148, ISSN: 0021-9290, DOI: 10.1016/j.jbiomech.2018.09.022	Journal of Biomechanics 81	2020-03-23
2018	VÃctor A. Acosta SantamarÃa, MarÃa Flechas GarcÃa, JÃ©rÃ´me Molimard, Stephane Avril Three-Dimensional Full-Field Strain Measurements across a Whole Porcine Aorta Subjected to Tensile Loading Using Optical Coherence Tomographyâ€“Digital Volume Correlation published pages: , ISSN: 2297-3079, DOI: 10.3389/fmech.2018.00003	Frontiers in Mechanical Engineering 4	2020-03-23
2018	V. A. Acosta SantamarÃa, G. Daniel, D. Perrin, J. N. Albertini, E. Rosset, S. Avril Model reduction methodology for computational simulations of endovascular repair published pages: 139-148, ISSN: 1025-5842, DOI: 10.1080/10255842.2018.1427740	Computer Methods in Biomechanics and Biomedical Engineering 21/2	2020-03-23
2019	Matthew R. Bersi, Chiara Bellini, Jay D. Humphrey, StÃ©phane Avril Local variations in material and structural properties characterize murine thoracic aortic aneurysm mechanics published pages: 203-218, ISSN: 1617-7959, DOI: 10.1007/s10237-018-1077-9	Biomechanics and Modeling in Mechanobiology 18/1	2020-03-23
2018	Nele Famaey, Julie Vastmans, Heleen Fehervary, Lauranne Maes, Emma Vanderveken, Filip Rega, S. Jamaleddin Mousavi, StÃ©phane Avril Numerical simulation of arterial remodeling in pulmonary autografts published pages: 2239-2257, ISSN: 0044-2267, DOI: 10.1002/zamm.201700351	ZAMM - Journal of Applied Mathematics and Mechanics / Zeitschrift fÃ¼r Angewandte Mathematik und Mechanik 98/12	2020-03-23
2018	Rossella Campobasso, Francesca Condemi, Magalie Viallon, Pierre Croisille, Salvatore Campisi, StÃ©phane Avril Evaluation of Peak Wall Stress in an Ascending Thoracic Aortic Aneurysm Using FSI Simulations: Effects of Aortic Stiffness and Peripheral Resistance published pages: 707-722, ISSN: 1869-408X, DOI: 10.1007/s13239-018-00385-z	Cardiovascular Engineering and Technology 9/4	2020-03-23
2019	Solmaz Farzaneh, Olfa Trabelsi, Bertrand Chavent, StÃ©phane Avril Identifying Local Arterial Stiffness to Assess the Risk of Rupture of Ascending Thoracic Aortic Aneurysms published pages: , ISSN: 0090-6964, DOI: 10.1007/s10439-019-02204-5	Annals of Biomedical Engineering	2020-03-23
2019	Solmaz Farzaneh, Olfa Trabelsi, StÃ©phane Avril Inverse identification of local stiffness across ascending thoracic aortic aneurysms published pages: 137-153, ISSN: 1617-7959, DOI: 10.1007/s10237-018-1073-0	Biomechanics and Modeling in Mechanobiology 18/1	2020-03-23

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