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MHAtriCell

Hyaluronan-rich matrices crosslinked with collagen-like peptides for 3D culture of ovarian cancer cells

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

MHAtriCell project word cloud

Explore the words cloud of the MHAtriCell project. It provides you a very rough idea of what is the project "MHAtriCell" about.

mechanisms matrix sequence cancer helical direct models drug engineering cleavable tissue assays sequences cells assisted hydrogel amphiphiles cell matrices motif characterise inhibitory electron degradation potency comprising recreating binding collagen biomaterial popular vivo invasion pa realistically microenvironment vitro metalloproteinase microscopic potent selector final encapsulation reflect contain 3d migration hyaluronan platform tme pas model techniques peptide relatively monolayer culture artificial tumour enzyme implications crosslinked adhesion newly creation cultures ovarian 2d biomaterials fabricate discovery inhibitor mmp triple

Project "MHAtriCell" data sheet

The following table provides information about the project.

Coordinator	QUEEN MARY UNIVERSITY OF LONDON Organization address address: 327 MILE END ROAD city: LONDON postcode: E1 4NS website: http://www.qmul.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Project website	http://www.sems.qmul.ac.uk/research/projects/
Total cost	183˙454 €
EC max contribution	183˙454 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2014
Funding Scheme	MSCA-IF-EF-ST
Starting year	2015
Duration (year-month-day)	from 2015-06-15 to 2017-06-14

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	QUEEN MARY UNIVERSITY OF LONDON QUEEN MARY UNIVERSITY OF LONDON Organization address address: 327 MILE END ROAD city: LONDON postcode: E1 4NS website: http://www.qmul.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	coordinator	183˙454.00

Map

Project objective

In recent years creation of artificial matrices from relatively simple biomaterials that can support tumour growth in 3D is becoming an increasingly popular platform for recreating the tumour microenvironment (TME) in vitro since 3D cell culture models can more realistically reflect the in vivo TME compared with 2D monolayer cultures. In this project, we will design and fabricate novel hydrogel matrices comprising of hyaluronan crosslinked with collagen-like triple helical peptide amphiphiles (PAs). The novel HA-PA matrix will contain built-in cell adhesion sequence, HA-binding motif and matrix metalloproteinase (MMP) cleavable sequences. We will characterise these 3D hydrogel matrices to support the encapsulation and culture of ovarian cancer cells. The MMP-assisted hydrogel degradation, migration and invasion of ovarian cancer will be studied on these models using advanced electron microscopic techniques and enzyme assays. In the final phase of our study we will characterise the inhibitory potency of a highly potent and selector inhibitor of MMP-2 and MMP-9 on this system. The findings from this study will have direct implications in understanding the mechanisms associated with ovarian cancer dissemination and the newly developed hydrogel matrix can find further use as a novel biomaterial in tissue engineering and as a 3D cell culture model in cancer drug discovery and delivery.

Publications

List of publications.
year	authors and title	journal	last update
2017	J. Banerjee, H. S. Azevedo Crafting of functional biomaterials by directed molecular self-assembly of triple helical peptide building blocks published pages: , ISSN: 2042-8898, DOI:	Interface Focus	2019-07-24
2016	Jayati Banerjee, Yejiao Shi, Helena S. Azevedo In vitro bloodâ€“brain barrier models for drug research: state-of-the-art and new perspectives on reconstituting these models on artificial basement membrane platforms published pages: , ISSN: 1359-6446, DOI: 10.1016/j.drudis.2016.05.020	Drug Discovery Today	2019-07-24

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