OPTIMALZ SIGNED
Optical imaging of ocular pathology in Alzheimer’s disease
Total Cost €
0EC-Contrib. €
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0OPTIMALZ project word cloud
Explore the words cloud of the OPTIMALZ project. It provides you a very rough idea of what is the project "OPTIMALZ" about.
Project "OPTIMALZ" data sheet
The following table provides information about the project.
| Coordinator |
MEDIZINISCHE UNIVERSITAET WIEN
Organization address contact info |
| Coordinator Country | Austria [AT] |
| Project website | http://optimalz.eu/ |
| Total cost | 1˙497˙000 € |
| EC max contribution | 1˙497˙000 € (100%) |
| Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
| Code Call | ERC-2014-STG |
| Funding Scheme | ERC-STG |
| Starting year | 2015 |
| Duration (year-month-day) | from 2015-09-01 to 2020-08-31 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | MEDIZINISCHE UNIVERSITAET WIEN | AT (WIEN) | coordinator | 1˙497˙000.00 |
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Project objective
Novel diagnostic techniques and disease models have the powerful potential to provide new insights into pathological and pathophysiological processes. Ocular manifestations of Alzheimer’s disease (AD) emerge as novel and attractive alternative to investigate disease progression in parallel to the brain. Using the eye as a window to the brain, we propose to develop multi-functional optical coherence tomography (OCT) as a noninvasive in-vivo technique for preclinical imaging of AD pathology. OCT is analogous to ultrasound B-mode imaging, using light rather than acoustical waves, and performs high-resolution real time 3D imaging of microstructure in biological tissues in situ. Based on the optical polarization properties or movement of particles, functional OCT methods provide additional contrast channels. In the proposed project, we will unite/join standard and functional OCT for imaging ocular and cerebral pathology in AD mouse models with threefold contrast. Structural changes caused by neuronal cell loss in the retina will be assessed longitudinally and with micron-scale resolution. Beta-amyloid plaques are birefringent and are deposited in both brain and retina in AD. We propose to exploit these intrinsic polarization properties for noninvasive detection and longitudinal characterization/assessment of retinal plaque load. Simultaneously, we will assess AD-related changes in retinal microvasculature. Retinal blood flow will be measured in quantitative units and monitored during disease progression. In addition to the retina, we will perform longitudinal imaging of AD-related lesions in the ocular lens with OCT. By correlating ocular AD pathology as imaged with OCT to cerebral lesions, the proposed research provides a new set of in vivo parameters that potentially shed new light on the pathogenesis and impact early diagnosis of AD in aging populations worldwide.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2020 |
Danielle J. Harper, Marco Augustin, Antonia Lichtenegger, Johanna Gesperger, Tanja Himmel, Martina Muck, Conrad W. Merkle, Pablo Eugui, Stefan Kummer, Adelheid Woehrer, Martin Glösmann, Bernhard Baumann Retinal analysis of a mouse model of Alzheimer’s disease with multicontrast optical coherence tomography published pages: 1, ISSN: 2329-423X, DOI: 10.1117/1.nph.7.1.015006 |
Neurophotonics 7/01 | 2020-04-07 |
| 2019 |
Pablo Eugui, Danielle J. Harper, Antonia Lichtenegger, Marco Augustin, Conrad W. Merkle, Adelheid Woehrer, Christoph K. Hitzenberger, Bernhard Baumann Polarization-sensitive imaging with simultaneous bright- and dark-field optical coherence tomography published pages: 4040, ISSN: 0146-9592, DOI: 10.1364/ol.44.004040 |
Optics Letters 44/16 | 2020-04-07 |
| 2020 |
Antonia Lichtenegger Multimodal visible light optical coherence microscopy for ex vivo brain imaging published pages: , ISSN: , DOI: |
2020-04-07 | |
| 2019 |
Antonia Lichtenegger, Johanna Gesperger, Barbara Kiesel, Martina Muck, Pablo Eugui, Danielle J. Harper, Matthias Salas, Marco Augustin, Conrad W. Merkle, Christoph K. Hitzenberger, Georg Widhalm, Adelheid Woehrer, Bernhard Baumann Revealing brain pathologies with multimodal visible light optical coherence microscopy and fluorescence imaging published pages: 1, ISSN: 1083-3668, DOI: 10.1117/1.jbo.24.6.066010 |
Journal of Biomedical Optics 24/06 | 2020-04-07 |
| 2019 |
Thomas Roetzer, Konrad Leskovar, Nadine Peter, Julia Furtner, Martina Muck, Marco Augustin, Antonia Lichtenegger, Martha Nowosielski, Johannes A. Hainfellner, Bernhard Baumann, Adelheid Woehrer Evaluating cellularity and structural connectivity on whole brain slides using a custom-made digital pathology pipeline published pages: 215-221, ISSN: 0165-0270, DOI: 10.1016/j.jneumeth.2018.10.029 |
Journal of Neuroscience Methods 311 | 2020-04-07 |
| 2019 |
Danielle J. Harper, Thomas Konegger, Marco Augustin, Kornelia Schützenberger, Pablo Eugui, Antonia Lichtenegger, Conrad W. Merkle, Christoph K. Hitzenberger, Martin Glösmann, Bernhard Baumann Hyperspectral optical coherence tomography for in vivo visualization of melanin in the retinal pigment epithelium published pages: 14, ISSN: 1864-063X, DOI: 10.1002/jbio.201900153 |
Journal of Biophotonics 12/12 | 2020-04-07 |
| 2019 |
Johanna Gesperger, Antonia Lichtenegger, Thomas Roetzer, Marco Augustin, Danielle J. Harper, Pablo Eugui, Conrad W. Merkle, Christoph K. Hitzenberger, Adelheid Woehrer, Bernhard Baumann Comparison of Intensity- and Polarization-based Contrast in Amyloid-beta Plaques as Observed by Optical Coherence Tomography published pages: 2100, ISSN: 2076-3417, DOI: 10.3390/app9102100 |
Applied Sciences 9/10 | 2020-04-07 |
| 2020 |
Danielle J. Harper Depth-resolved multi-contrast retinal imaging with high axial resolution published pages: , ISSN: , DOI: |
2020-04-07 | |
| 2019 |
Bernhard Baumann, Conrad W. Merkle, Rainer A. Leitgeb, Marco Augustin, Andreas Wartak, Michael Pircher, Christoph K. Hitzenberger Signal averaging improves signal-to-noise in OCT images: But which approach works best, and when? published pages: 5755, ISSN: 2156-7085, DOI: 10.1364/boe.10.005755 |
Biomedical Optics Express 10/11 | 2020-04-07 |
| 2016 |
Stanislava Fialová High resolution polarization sensitive optical coherence tomography for ocular imaging in small animals published pages: , ISSN: , DOI: |
2020-04-07 | |
| 2018 |
Danielle J. Harper, Marco Augustin, Antonia Lichtenegger, Pablo Eugui, Carlos Reyes, Martin Glösmann, Christoph K. Hitzenberger, Bernhard Baumann White light polarization sensitive optical coherence tomography for sub-micron axial resolution and spectroscopic contrast in the murine retina published pages: 2115, ISSN: 2156-7085, DOI: 10.1364/boe.9.002115 |
Biomedical Optics Express 9/5 | 2020-04-07 |
| 2017 |
Antonia Lichtenegger, Danielle J. Harper, Marco Augustin, Pablo Eugui, Martina Muck, Johanna Gesperger, Christoph K. Hitzenberger, Adelheid Woehrer, Bernhard Baumann Spectroscopic imaging with spectral domain visible light optical coherence microscopy in Alzheimer’s disease brain samples published pages: 4007, ISSN: 2156-7085, DOI: 10.1364/BOE.8.004007 |
Biomedical Optics Express 8/9 | 2020-04-07 |
| 2018 |
Marco Augustin, Danielle J. Harper, Conrad W. Merkle, Christoph K. Hitzenberger, Bernhard Baumann Segmentation of Retinal Layers in OCT Images of the Mouse Eye Utilizing Polarization Contrast published pages: 310-318, ISSN: , DOI: 10.1007/978-3-030-00949-6_37 |
2020-04-07 | |
| 2018 |
Marco Augustin Multi-Functional Optical Coherence Tomography for Preclinical Retinal Imaging published pages: , ISSN: , DOI: |
2020-04-07 | |
| 2016 |
Marco Augustin, Stanislava Fialová, Tanja Himmel, Martin Glösmann, Theresia Lengheimer, Danielle J. Harper, Roberto Plasenzotti, Michael Pircher, Christoph K. Hitzenberger, Bernhard Baumann Multi-Functional OCT Enables Longitudinal Study of Retinal Changes in a VLDLR Knockout Mouse Model published pages: 164419, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0164419 |
PLOS one 11(10) | 2020-04-07 |
| 2017 |
Bernhard Baumann, Adelheid Woehrer, Gerda Ricken, Marco Augustin, Christian Mitter, Michael Pircher, Gabor G. Kovacs, Christoph K. Hitzenberger Visualization of neuritic plaques in Alzheimer’s disease by polarization-sensitive optical coherence microscopy published pages: 43477, ISSN: 2045-2322, DOI: 10.1038/srep43477 |
Scientific Reports 7 | 2020-04-07 |
| 2017 |
Stanislava Fialová, Marco Augustin, Corinna Fischak, Leopold Schmetterer, Stephan Handschuh, Martin Glösmann, Michael Pircher, Christoph K. Hitzenberger, Bernhard Baumann Posterior rat eye during acute intraocular pressure elevation studied using polarization sensitive optical coherence tomography published pages: 298-314, ISSN: 2156-7085, DOI: 10.1364/BOE.8.000298 |
Biomedical Optics Express 8 | 2020-04-07 |
| 2017 |
Marco Augustin, Stanislava Fialová, Corinna Fischak, Leopold Schmetterer, Christoph K. Hitzenberger, Bernhard Baumann Ocular fundus pulsations within the posterior rat eye: Chorioscleral motion and response to elevated intraocular pressure published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-017-09310-1 |
Scientific Reports 7/1 | 2020-04-07 |
| 2018 |
Bernhard Baumann, Marco Augustin, Antonia Lichtenegger, Danielle J. Harper, Martina Muck, Pablo Eugui, Andreas Wartak, Michael Pircher, Christoph K. Hitzenberger Polarization-sensitive optical coherence tomography imaging of the anterior mouse eye published pages: 1, ISSN: 1083-3668, DOI: 10.1117/1.JBO.23.8.086005 |
Journal of Biomedical Optics 23/08 | 2020-04-07 |
| 2018 |
Rainer A. Leitgeb, Bernhard Baumann Multimodal Optical Medical Imaging Concepts Based on Optical Coherence Tomography published pages: 114, ISSN: 2296-424X, DOI: 10.3389/fphy.2018.00114 |
Frontiers in Physics 6 | 2020-04-07 |
| 2018 |
Antonia Lichtenegger, Martina Muck, Pablo Eugui, Danielle J. Harper, Marco Augustin, Konrad Leskovar, Christoph K. Hitzenberger, Adelheid Woehrer, Bernhard Baumann Assessment of pathological features in Alzheimer’s disease brain tissue with a large field-of-view visible-light optical coherence microscope published pages: 1, ISSN: 2329-423X, DOI: 10.1117/1.NPh.5.3.035002 |
Neurophotonics 5/03 | 2020-04-07 |
| 2018 |
Johanna Klughammer, Barbara Kiesel, Thomas Roetzer, Nikolaus Fortelny, Amelie Nemc, Karl-Heinz Nenning, Julia Furtner, Nathan C. Sheffield, Paul Datlinger, Nadine Peter, Martha Nowosielski, Marco Augustin, Mario Mischkulnig, Thomas Ströbel, Donat Alpar, Bekir Ergüner, Martin Senekowitsch, Patrizia Moser, Christian F. Freyschlag, Johannes Kerschbaumer, Claudius Thomé, Astrid E. Grams, Günther Stockhammer, Melitta Kitzwoegerer, Stefan Oberndorfer, Franz Marhold, Serge Weis, Johannes Trenkler, Johanna Buchroithner, Josef Pichler, Johannes Haybaeck, Stefanie Krassnig, Kariem Mahdy Ali, Gord von Campe, Franz Payer, Camillo Sherif, Julius Preiser, Thomas Hauser, Peter A. Winkler, Waltraud Kleindienst, Franz Würtz, Tanisa Brandner-Kokalj, Martin Stultschnig, Stefan Schweiger, Karin Dieckmann, Matthias Preusser, Georg Langs, Bernhard Baumann, Engelbert Knosp, Georg Widhalm, Christine Marosi, Johannes A. Hainfellner, Adelheid Woehrer, Christoph Bock The DNA methylation landscape of glioblastoma disease progression shows extensive heterogeneity in time and space published pages: 1611-1624, ISSN: 1078-8956, DOI: 10.1038/s41591-018-0156-x |
Nature Medicine 24/10 | 2020-04-07 |
| 2018 |
Pablo Eugui, Antonia Lichtenegger, Marco Augustin, Danielle J. Harper, Martina Muck, Thomas Roetzer, Andreas Wartak, Thomas Konegger, Georg Widhalm, Christoph K. Hitzenberger, Adelheid Woehrer, Bernhard Baumann Beyond backscattering: optical neuroimaging by BRAD published pages: 2476, ISSN: 2156-7085, DOI: 10.1364/BOE.9.002476 |
Biomedical Optics Express 9/6 | 2020-04-07 |
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