#	Pagina
attuale pagina	/open-h2020/projects/198436/index.html

Opendata, web and dolomites

DrugsInPregnancy SIGNED

Effects of Medication Use in Pregnancy on Infant Neurodevelopment

Total Cost €

EC-Contrib. €

Partnership

Views

Outcomes and
results

DrugsInPregnancy project word cloud

Explore the words cloud of the DrugsInPregnancy project. It provides you a very rough idea of what is the project "DrugsInPregnancy" about.

linking human risks existence cohort effect dna national analgesics inference hypothesize population pregnant fundamentally psychotropics currently epigenetic neurodevelopment oversimplified base childhood pharmacology unrecognized worldwide medication young medications disorders register safety hundred pregnancy genome act mapping thousands mother opportunity 108 exposure norwegian methylation prenatal prescription richness patient registries thousand origins size child events methodological innovative estimate outcome registry pairs final made birth affordable unborn causal pregnancies possibility fetal n medical material children epigenetics neurodevelopmental pharmaco prescribed biological strengthen play women offspring linkages sufficient data horizons nationwide offers pharmaceutical

Project "DrugsInPregnancy" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITETET I OSLO Organization address address: PROBLEMVEIEN 5-7 city: OSLO postcode: 313 website: www.uio.no contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Norway [NO]
Project website	http://www.mn.uio.no/farmasi/english/research/projects/drug-in-pregnancy/
Total cost	1˙499˙439 €
EC max contribution	1˙499˙439 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2014-STG
Funding Scheme	ERC-STG
Starting year	2015
Duration (year-month-day)	from 2015-09-01 to 2020-08-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITETET I OSLO UNIVERSITETET I OSLO Organization address address: PROBLEMVEIEN 5-7 city: OSLO postcode: 313 website: www.uio.no contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NO (OSLO)	coordinator	1˙499˙439.00

Map

Project objective

Currently, thousands of pregnant women in the EU and worldwide are being increasingly prescribed medications for which we do not have sufficient information on fetal safety. I hypothesize that our current understanding of safety pharmacology is oversimplified and that medication prescribed during pregnancy may play an unrecognized role in the development of neurodevelopmental disorders. In this research proposal we have the unique opportunity to use a large population-based birth cohort including over 100 000 mother-child pairs and biological data to study how medications may act on the offspring. This offers novel and innovative pharmaceutical insight into the safety of medications. By linking several nationwide registries (National Prescription Data Base, Norwegian Patient Registry, Medical Birth Registry) to a population-based birth cohort (n=108 000) we specifically aim to 1) estimate the effect of prenatal exposure to psychotropics and analgesics on neurodevelopment in young children using a range of methodological approaches to strengthen causal inference. With these data made available, we will 2) determine whether fetal exposure to specific medications results in epigenetic events (i.e. changes in DNA methylation) in the child, and 3) determine whether such changes increase the risks of neurodevelopmental disorders in childhood. The recent availability of large scale human data, possibility of register linkages and genome-wide mapping of DNA methylation at affordable costs makes this research proposal now possible. The size and richness of data including over hundred thousand pregnancies and existence of biological material makes this project unique. The final outcome will be fundamentally new knowledge about how medications affect the developing unborn child and will open up new horizons and opportunities for future research in a new field of “pharmaco-epigenetics” and enhance our understanding of origins of neurodevelopmental disorders.

Publications

List of publications.
year	authors and title	journal	last update
2019	Jacqueline M Cohen, Mollie E Wood, Sonia HernÃ¡ndez-DÃaz, Eivind Ystrom, Hedvig Nordeng Paternal antidepressant use as a negative control for maternal use: assessing familial confounding on gestational length and anxiety traits in offspring published pages: 1665-1672, ISSN: 0300-5771, DOI: 10.1093/ije/dyz170	International Journal of Epidemiology 48/5	2020-04-15
2019	Michael Ceulemans, Angela Lupattelli, Hedvig Nordeng, Marina Odalovic, Michael Twigg, Veerle Foulon Womenâ€™s Beliefs About Medicines and Adherence to Pharmacotherapy in Pregnancy: Opportunities for Community Pharmacists published pages: 469-482, ISSN: 1381-6128, DOI: 10.2174/1381612825666190321110420	Current Pharmaceutical Design 25/5	2020-04-15
2019	Frank, Anna-Simone Josefine Thyroid hormone replacement therapy during pregnancy â€“ Quantifying medication patterns and associated outcomes in the offspring published pages: , ISSN: , DOI:		2020-04-15
2019	Angela Lupattelli, Mollie E. Wood, Hedvig Nordeng Analyzing Missing Data in Perinatal Pharmacoepidemiology Research: Methodological Considerations to Limit the Risk of Bias published pages: 2477-2487, ISSN: 0149-2918, DOI: 10.1016/j.clinthera.2019.11.003	Clinical Therapeutics 41/12	2020-03-31
2019	Johanne N. TrÃ¸nnes, Mollie Wood, Angela Lupattelli, Eivind Ystrom, Hedvig Nordeng Prenatal paracetamol exposure and neurodevelopmental outcomes in preschoolâ€aged children published pages: , ISSN: 0269-5022, DOI: 10.1111/ppe.12568	Paediatric and Perinatal Epidemiology	2020-03-31
2019	Anna S. Frank, Angela Lupattelli, Ragnhild E. Brandlistuen, Hedvig Nordeng Maternal Thyroid Hormone Replacement Therapy Exposure and Language and Communication Skills of Offspring at 8 Years of Age published pages: e1912424, ISSN: 2574-3805, DOI: 10.1001/jamanetworkopen.2019.12424	JAMA Network Open 2/10	2020-03-31
2018	Anna S. Frank, Angela Lupattelli, David S. Matteson, Hedvig Nordeng Maternal use of thyroid hormone replacement therapy before, during, and after pregnancy: agreement between self-report and prescription records and group-based trajectory modeling of prescription patterns published pages: 1801-1816, ISSN: 1179-1349, DOI: 10.2147/clep.s175616	Clinical Epidemiology Volume 10	2020-03-31
2019	Anna S. Frank, Angela Lupattelli, David S. Matteson, Helle Margrete Meltzer, Hedvig Nordeng Thyroid hormone replacement therapy patterns in pregnant women and perinatal outcomes in the offspring published pages: 111-121, ISSN: 1053-8569, DOI: 10.1002/pds.4927	Pharmacoepidemiology and Drug Safety 29/1	2020-03-31
2019	Sarah Hjorth, Rebecca Bromley, Eivind Ystrom, Angela Lupattelli, Olav Spigset, Hedvig Nordeng Use and validity of child neurodevelopment outcome measures in studies on prenatal exposure to psychotropic and analgesic medications â€“ A systematic review published pages: e0219778, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0219778	PLOS ONE 14/7	2020-03-31
2019	Angela Lupattelli, Christina D. Chambers, Gretchen Bandoli, Marte Handal, Svetlana Skurtveit, Hedvig Nordeng Association of Maternal Use of Benzodiazepines and Z-Hypnotics During Pregnancy With Motor and Communication Skills and Attention-Deficit/Hyperactivity Disorder Symptoms in Preschoolers published pages: e191435, ISSN: 2574-3805, DOI: 10.1001/jamanetworkopen.2019.1435	JAMA Network Open 2/4	2020-03-31
2019	Kristina Gervin, Lucas A. Salas, Kelly M. Bakulski, Menno C. van Zelm, Devin C. Koestler, John K. Wiencke, Liesbeth Duijts, HenriÃ«tte A. Moll, Karl T. Kelsey, Michael S. Kobor, Robert Lyle, Brock C. Christensen, Janine F. Felix, Meaghan J. Jones Systematic evaluation and validation of reference and library selection methods for deconvolution of cord blood DNA methylation data published pages: , ISSN: 1868-7075, DOI: 10.1186/s13148-019-0717-y	Clinical Epigenetics 11/1	2020-03-31
2019	Gro C. Havnen, Maria Bich-Thuy Truong, Mai-Linh H. Do, Kristine Heitmann, Lone Holst, Hedvig Nordeng Womenâ€™s perspectives on the management and consequences of hyperemesis gravidarum â€“ a descriptive interview study published pages: 30-40, ISSN: 0281-3432, DOI: 10.1080/02813432.2019.1569424	Scandinavian Journal of Primary Health Care 37/1	2020-03-31
2020	Emil A Stoltenberg, Hedvig ME Nordeng, Eivind Ystrom, Sven O Samuelsen The cure model in perinatal epidemiology published pages: 96228022090409, ISSN: 0962-2802, DOI: 10.1177/0962280220904092	Statistical Methods in Medical Research	2020-03-31
2016	Kristina Gervin, Christian Magnus Page, Hans Christian D. Aass, Michelle A. Jansen, Heidi Elisabeth Fjeldstad, Bettina Kulle Andreassen, Liesbeth Duijts, Joyce B. van Meurs, Menno C. van Zelm, Vincent W. Jaddoe, Hedvig Nordeng, Gunn Peggy Knudsen, Per Magnus, Wenche Nystad, Anne Cathrine Staff, Janine F. Felix, Robert Lyle Cell type specific DNA methylation in cord blood: A 450K-reference data set and cell count-based validation of estimated cell type composition published pages: 690-698, ISSN: 1559-2294, DOI: 10.1080/15592294.2016.1214782	Epigenetics 11/9	2019-05-29
2017	Stefania Salvatore, Diana Domanska, Mollie Wood, Hedvig Nordeng, Geir Kjetil Sandve Complex patterns of concomitant medication use: A study among Norwegian women using paracetamol during pregnancy published pages: e0190101, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0190101	PLOS ONE 12/12	2019-05-29
2016	Hedvig Nordeng Drug utilization in pregnant women published pages: 240-247, ISSN: , DOI: 10.1002/9781118949740.ch23	Drug Utilization Research: Methods and Applications	2019-05-29
2017	Hedvig Nordeng, Angela Lupattelli, Mollie Wood Prenatal exposure to antidepressants and increased risk of psychiatric disorders published pages: j3950, ISSN: 0959-8138, DOI: 10.1136/bmj.j3950	BMJ	2019-05-29
2018	Mollie E. Wood, Stavroula Chrysanthopoulou, Hedvig M.E. Nordeng, Kate L. Lapane The Impact of Nondifferential Exposure Misclassification on the Performance of Propensity Scores for Continuous and Binary Outcomes published pages: 1, ISSN: 0025-7079, DOI: 10.1097/MLR.0000000000000800	Medical Care	2019-05-29
2017	Angela Lupattelli, Mollie Wood, Kate Lapane, Olav Spigset, Hedvig Nordeng Risk of preeclampsia after gestational exposure to selective serotonin reuptake inhibitors and other antidepressants: A study from The Norwegian Mother and Child Cohort Study published pages: 1266-1276, ISSN: 1053-8569, DOI: 10.1002/pds.4286	Pharmacoepidemiology and Drug Safety 26/10	2019-05-29
2017	Eivind Ystrom, Kristin Gustavson, Ragnhild Eek Brandlistuen, Gun Peggy Knudsen, Per Magnus, Ezra Susser, George Davey Smith, Camilla Stoltenberg, PÃ¥l SurÃ©n, Siri E. HÃ¥berg, Mady Hornig, W. Ian Lipkin, Hedvig Nordeng, Ted Reichborn-Kjennerud Prenatal Exposure to Acetaminophen and Risk of ADHD published pages: e20163840, ISSN: 0031-4005, DOI: 10.1542/peds.2016-3840	Pediatrics 140/5	2019-05-29
2018	Anna S. Frank, Angela Lupattelli, Hedvig Nordeng Risk factors for discontinuation of thyroid hormone replacement therapy in early pregnancy: a study from the Norwegian Mother and Child Cohort Study and the Medical Birth Registry of Norway published pages: , ISSN: 0001-6349, DOI: 10.1111/aogs.13339	Acta Obstetricia et Gynecologica Scandinavica	2019-05-29
2017	Gerd-Marie Eskerud Harris, Mollie Wood, Malin Eberhard-Gran, Christofer Lundqvist, Hedvig Nordeng Patterns and predictors of analgesic use in pregnancy: a longitudinal drug utilization study with special focus on women with migraine published pages: , ISSN: 1471-2393, DOI: 10.1186/s12884-017-1399-0	BMC Pregnancy and Childbirth 17/1	2019-05-29
2017	Johanne N. TrÃ¸nnes, Angela Lupattelli, Hedvig Nordeng Safety profile of medication used during pregnancy: results of a multinational European study published pages: 802-811, ISSN: 1053-8569, DOI: 10.1002/pds.4213	Pharmacoepidemiology and Drug Safety 26/7	2019-05-29
2018	Mollie E. Wood, Kate L. Lapane, Marleen M.H.J. van Gelder, Dheeraj Rai, Hedvig M.E. Nordeng Making fair comparisons in pregnancy medication safety studies: An overview of advanced methods for confounding control published pages: 140-147, ISSN: 1053-8569, DOI: 10.1002/pds.4336	Pharmacoepidemiology and Drug Safety 27/2	2019-05-29
2017	Susan E. Andrade, Anick BÃ©rard, Hedvig M.E. Nordeng, Mollie E. Wood, Marleen M.H.J. van Gelder, Sengwee Toh Administrative Claims Data Versus Augmented Pregnancy Data for the Study of Pharmaceutical Treatments in Pregnancy published pages: 106-116, ISSN: 2196-2995, DOI: 10.1007/s40471-017-0104-1	Current Epidemiology Reports 4/2	2019-05-29
2017	Kristina Gervin, Hedvig Nordeng, Eivind Ystrom, Ted Reichborn-Kjennerud, Robert Lyle Long-term prenatal exposure to paracetamol is associated with DNA methylation differences in children diagnosed with ADHD published pages: , ISSN: 1868-7075, DOI: 10.1186/s13148-017-0376-9	Clinical Epigenetics 9/1	2019-05-29
2018	Gerd-Marie Eskerud Harris, Mollie Wood, Eivind Ystrom, Hedvig Nordeng Prenatal triptan exposure and neurodevelopmental outcomes in 5-year-old children: Follow-up from the Norwegian Mother and Child Cohort Study published pages: , ISSN: 0269-5022, DOI: 10.1111/ppe.12461	Paediatric and Perinatal Epidemiology	2019-05-29
2017	Ragnhild E. Brandlistuen, Eivind Ystrom, Sonia Hernandez-Diaz, Svetlana Skurtveit, Randi Selmer, Marte Handal, Hedvig Nordeng Association of prenatal exposure to benzodiazepines and child internalizing problems: A sibling-controlled cohort study published pages: e0181042, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0181042	PLOS ONE 12/7	2019-05-29
2016	Olav Spigset, Hedvig Nordeng Safety of Psychotropic Drugs in Pregnancy and Breastfeeding published pages: 299-319, ISSN: , DOI: 10.1007/978-3-319-24741-0_15	Pharmacovigilance in Psychiatry	2019-05-29
2018	Jacqueline M. Cohen, Mollie E. Wood, Sonia Hernandez-Diaz, Hedvig Nordeng Agreement between paternal self-reported medication use and records from a national prescription database published pages: 413-421, ISSN: 1053-8569, DOI: 10.1002/pds.4411	Pharmacoepidemiology and Drug Safety 27/4	2019-05-29
2018	Angela Lupattelli, Michael J Twigg, Ksenia Zagorodnikova, Myla E Moretti, Mariola Drozd, Alice Panchaud, Andre Rieutord, Romana Gjergja Juraski, Marina Odalovic, Debra Kennedy, Gorazd Rudolf, Herbert Juch, Hedvig Marie Egeland Nordeng Self-reported perinatal depressive symptoms and postnatal symptom severity after treatment with antidepressants in pregnancy: a cross-sectional study across 12 European countries using the Edinburgh Postnatal Depression Scale published pages: 655-669, ISSN: 1179-1349, DOI: 10.2147/CLEP.S156210	Clinical Epidemiology Volume 10	2019-04-03
2018	Angela Lupattelli, Elke Ronningen, Stine Kleppe Krogsrud, Hedvig Nordeng, Eivind Ystrom Personality and its relation to the use of alcohol and cigarettes during pregnancy: A multinational study published pages: 135910531877519, ISSN: 1359-1053, DOI: 10.1177/1359105318775194	Journal of Health Psychology	2019-04-03
2018	Angela Lupattelli, Olav Spigset, Hedvig Nordeng Learning the effects of psychotropic drugs during pregnancy using real-world safety data: a paradigm shift toward modern pharmacovigilance published pages: 783-786, ISSN: 2210-7703, DOI: 10.1007/s11096-018-0672-2	International Journal of Clinical Pharmacy 40/4	2019-04-02

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "DRUGSINPREGNANCY" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "DRUGSINPREGNANCY" are provided by the European Opendata Portal: CORDIS opendata.