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EU-ToxRisk SIGNED

An Integrated European ‘Flagship’ Program Driving Mechanism-based Toxicity Testing and Risk Assessment for the 21st Century

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

EU-ToxRisk project word cloud

Explore the words cloud of the EU-ToxRisk project. It provides you a very rough idea of what is the project "EU-ToxRisk" about.

solid toxicokinetics strategies regulatory outcome chemicals systemic strategy events iterative disciplines extensively mechanistic integrates nervous ke structured liver drive vivo agro dose microscopy toxicokinetic chemical assays flexible read toxicology animal forms aop service interference vision activation ab tools biological throughput hazard algorithms aops combined kidney industry sectors toxicity toxrisk reproduction extrapolation basis pharma fit optimization complexity stakeholders background proof mechanism broad combines lung data technologies free balance purpose training silico validation rna tiered computational developmental shift unite vitro quantitative spectrum phases initio safety risk adverse plan underpinning paradigm incorporating regulators pragmatic speed cosmetics continued transcriptomics human flagship little repeated

Project "EU-ToxRisk" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITEIT LEIDEN Organization address address: RAPENBURG 70 city: LEIDEN postcode: 2311 EZ website: www.universiteitleiden.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Netherlands [NL]
Project website	http://www.eu-toxrisk.eu/
Total cost	30˙122˙153 €
EC max contribution	27˙798˙299 € (92%)
Programme	1. H2020-EU.3.1.6. (Health care provision and integrated care)
Code Call	H2020-PHC-2015-single-stage_RTD
Funding Scheme	RIA
Starting year	2016
Duration (year-month-day)	from 2016-01-01 to 2021-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITEIT LEIDEN UNIVERSITEIT LEIDEN Organization address address: RAPENBURG 70 city: LEIDEN postcode: 2311 EZ website: www.universiteitleiden.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (LEIDEN)	coordinator	4˙672˙069.00
2	UNIVERSITAT KONSTANZ UNIVERSITAT KONSTANZ Organization address address: UNIVERSITATSSTRASSE 10 city: KONSTANZ postcode: 78464 website: www.uni-konstanz.de/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (KONSTANZ)	participant	1˙408˙187.00
3	ARTTIC ARTTIC Organization address address: RUE DU DESSOUS DES BERGES 58A city: PARIS postcode: 75013 website: www.arttic.eu contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	participant	1˙395˙580.00
4	KAROLINSKA INSTITUTET KAROLINSKA INSTITUTET Organization address address: Nobels Vag 5 city: STOCKHOLM postcode: 17177 website: www.ki.se contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (STOCKHOLM)	participant	1˙295˙810.00
5	UNIVERSITEIT MAASTRICHT UNIVERSITEIT MAASTRICHT Organization address address: Minderbroedersberg 4-6 city: MAASTRICHT postcode: 6200 MD website: http://www.maastrichtuniversity.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (MAASTRICHT)	participant	1˙282˙235.00
6	CYPROTEX DISCOVERY LIMITED CYPROTEX DISCOVERY LIMITED Organization address address: 114 INNOVATION DRIVE MILTON PARK city: ABINGDON OXFORDSHIRE postcode: OX14 4RZ website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (ABINGDON OXFORDSHIRE)	participant	1˙176˙455.00
7	FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V. FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V. Organization address address: HANSASTRASSE 27C city: MUNCHEN postcode: 80686 website: www.fraunhofer.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (MUNCHEN)	participant	1˙057˙335.00
8	BioDetection Systems B.V. BioDetection Systems B.V. Organization address address: Science Park 406 city: Amsterdam postcode: 1098 XH website: www.biodetectionsystems.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (Amsterdam)	participant	960˙218.00
9	FORSCHUNGSGESELLSCHAFT FUR ARBEITSPHYSIOLOGIE UND ARBEITSSCHUTZ E.V. FORSCHUNGSGESELLSCHAFT FUR ARBEITSPHYSIOLOGIE UND ARBEITSSCHUTZ E.V. Organization address address: ARDEYSTRASSE 67 city: DORTMUND postcode: 44139 website: http://www.ifado.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (DORTMUND)	participant	930˙375.00
10	ISTITUTO DI RICERCHE FARMACOLOGICHE MARIO NEGRI ISTITUTO DI RICERCHE FARMACOLOGICHE MARIO NEGRI Organization address address: VIA MARIO NEGRI 2 city: MILANO postcode: 20156 website: www.marionegri.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (MILANO)	participant	930˙065.00
11	EUROPEAN MOLECULAR BIOLOGY LABORATORY EUROPEAN MOLECULAR BIOLOGY LABORATORY Organization address address: Meyerhofstrasse 1 city: HEIDELBERG postcode: 69117 website: http://www.embl.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (HEIDELBERG)	participant	850˙005.00
12	STEINBEIS GMBH & CO. KG FUER TECHNOLOGIETRANSFER STEINBEIS GMBH & CO. KG FUER TECHNOLOGIETRANSFER Organization address address: WILLI-BLEICHER-STRASSE HAUS DER WIRTSCHAFT 19 city: STUTTGART postcode: 70174 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (STUTTGART)	participant	804˙130.00
13	KATHOLIEKE UNIVERSITEIT LEUVEN KATHOLIEKE UNIVERSITEIT LEUVEN Organization address address: OUDE MARKT 13 city: LEUVEN postcode: 3000 website: www.kuleuven.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (LEUVEN)	participant	790˙690.00
14	ACADEMISCH ZIEKENHUIS LEIDEN ACADEMISCH ZIEKENHUIS LEIDEN Organization address address: ALBINUSDREEF 2 city: LEIDEN postcode: 2333 ZA website: www.lumc.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (LEIDEN)	participant	773˙260.00
15	KOBENHAVNS UNIVERSITET KOBENHAVNS UNIVERSITET Organization address address: NORREGADE 10 city: KOBENHAVN postcode: 1165 website: www.ku.dk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (KOBENHAVN)	participant	767˙500.00
16	BIOTALENTUM TUDASFEJLESZTO KFT BIOTALENTUM TUDASFEJLESZTO KFT Organization address address: AULICH LAJOS UTCA 26 city: GOEDOELLO postcode: 2100 website: www.biotalentum.hu contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	HU (GOEDOELLO)	participant	744˙476.00
17	INSTITUT NATIONAL DE L ENVIRONNEMENT ET DES RISQUES INERIS INSTITUT NATIONAL DE L ENVIRONNEMENT ET DES RISQUES INERIS Organization address address: Parc Technologique Alata city: VERNEUIL EN HALATTE postcode: 60550 website: www.ineris.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (VERNEUIL EN HALATTE)	participant	725˙015.00
18	UNIVERSIDAD POMPEU FABRA UNIVERSIDAD POMPEU FABRA Organization address address: PLACA DE LA MERCE, 10-12 city: BARCELONA postcode: 8002 website: www.upf.edu contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (BARCELONA)	participant	723˙190.00
19	STICHTING VU STICHTING VU Organization address address: DE BOELELAAN 1105 city: AMSTERDAM postcode: 1081 HV website: www.vu.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (AMSTERDAM)	participant	720˙387.00
20	BASF SE BASF SE Organization address address: CARL BOSCH STRASSE 38 city: LUDWIGSHAFEN AM RHEIN postcode: 67063 website: www.basf.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (LUDWIGSHAFEN AM RHEIN)	participant	695˙410.00
21	TISSUSE GMBH TISSUSE GMBH Organization address address: OUDENARDER STRASSE 16 city: BERLIN postcode: 13347 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (BERLIN)	participant	695˙065.00
22	CERTARA UK LIMITED CERTARA UK LIMITED Organization address address: ONE LONDON WALL 6TH FLOOR city: LONDON postcode: EC2Y 5EB website: www.certara.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	participant	670˙765.00
23	FUNDACION PARA LA INVESTIGACION DEL HOSPITAL UNIVERSITARIO LA FE DE LA COMUNIDAD VALENCIANA FUNDACION PARA LA INVESTIGACION DEL HOSPITAL UNIVERSITARIO LA FE DE LA COMUNIDAD VALENCIANA Organization address address: AV FERNANDO ABRIL MARTORELL 106 city: VALENCIA postcode: 46026 website: http://www.iislafe.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (VALENCIA)	participant	641˙940.00
24	NEDERLANDSE ORGANISATIE VOOR TOEGEPAST NATUURWETENSCHAPPELIJK ONDERZOEK TNO NEDERLANDSE ORGANISATIE VOOR TOEGEPAST NATUURWETENSCHAPPELIJK ONDERZOEK TNO Organization address address: ANNA VAN BUERENPLEIN 1 city: DEN HAAG postcode: 2595 DA website: www.tno.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (DEN HAAG)	participant	626˙345.00
25	UNIVERSITAT WIEN UNIVERSITAT WIEN Organization address address: UNIVERSITATSRING 1 city: WIEN postcode: 1010 website: www.univie.ac.at contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	AT (WIEN)	participant	594˙061.00
26	JOHNS HOPKINS UNIVERSITY JOHNS HOPKINS UNIVERSITY Organization address address: NORTH CHARLES STREET 3400 city: BALTIMORE postcode: 21218 website: www.hopkinsmedicine.org contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	US (BALTIMORE)	participant	515˙762.00
27	RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG Organization address address: SEMINARSTRASSE 2 city: HEIDELBERG postcode: 69117 website: www.uni-heidelberg.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (HEIDELBERG)	participant	457˙718.00
28	LHASA LIMITED LHASA LIMITED Organization address address: GRANARY WHARF HOUSE, 2 CANAL WHARF city: LEEDS postcode: LS11 5PS website: www.lhasalimited.org contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LEEDS)	participant	325˙000.00
29	MEDIZINISCHE UNIVERSITAT INNSBRUCK MEDIZINISCHE UNIVERSITAT INNSBRUCK Organization address address: CHRISTOPH PROBST PLATZ 1 city: INNSBRUCK postcode: 6020 website: www.i-med.ac.at contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	AT (INNSBRUCK)	participant	256˙237.00
30	The Danish Environmental Protection Agency The Danish Environmental Protection Agency Organization address address: Strandgade 29 city: Copenhagen postcode: 1401 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (Copenhagen)	participant	77˙750.00
31	UNITED KINGDOM RESEARCH AND INNOVATION UNITED KINGDOM RESEARCH AND INNOVATION Organization address address: POLARIS HOUSE NORTH STAR AVENUE city: SWINDON postcode: SN2 1FL website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (SWINDON)	participant	71˙570.00
32	ISTITUTO SUPERIORE DI SANITA ISTITUTO SUPERIORE DI SANITA Organization address address: Viale Regina Elena 299 city: ROMA postcode: 161 website: http://www.iss.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (ROMA)	participant	64˙000.00
33	BUNDESANSTALT FUER ARBEITSSCHUTZ UND ARBEITSMEDIZIN BUNDESANSTALT FUER ARBEITSSCHUTZ UND ARBEITSMEDIZIN Organization address address: FRIEDRICH HENKEL WEG 1-25 city: DORTMUND postcode: 44149 website: http://www.baua.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (DORTMUND)	participant	53˙250.00
34	UNILEVER U.K. CENTRAL RESOURCES LIMITED UNILEVER U.K. CENTRAL RESOURCES LIMITED Organization address address: UNILEVER HOUSE, VICTORIA EMBANKMENT 100 city: LONDON postcode: EC4Y 0DY website: www.unilever.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	participant	21˙000.00
35	L'OREAL SA L'OREAL SA Organization address address: 14 RUE ROYALE city: PARIS postcode: 75008 website: www.loreal.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	participant	14˙440.00
36	OPEN PHACTS FOUNDATION LBG OPEN PHACTS FOUNDATION LBG Organization address address: MILTON ROAD 290 292 SCIENCE PARK THOMAS GRAHAM HOUSE city: CAMBRIDGE postcode: CB4 0WF website: http://www.openphactsfoundation.org contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (CAMBRIDGE)	participant	11˙000.00
37	COSMETICS EUROPE - THE PERSONAL CARE ASSOCIATION COSMETICS EUROPE - THE PERSONAL CARE ASSOCIATION Organization address address: Avenue Herrmann Debroux 40 city: Brussels postcode: 1160 website: www.cosmeticseurope.eu contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (Brussels)	participant	0.00
38	EDELWEISS CONNECT GMBH EDELWEISS CONNECT GMBH Organization address address: HOCHBERGERSTRASSE 60C city: BASEL postcode: 4057 website: http://www.douglasconnect.com/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (BASEL)	participant	0.00
39	F. HOFFMANN-LA ROCHE AG F. HOFFMANN-LA ROCHE AG Organization address address: GRENZACHERSTRASSE 124 city: BASEL postcode: 4070 website: www.roche.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (BASEL)	participant	0.00
40	INSPHERO AG INSPHERO AG Organization address address: WAGISTRASSE 27 city: SCHLIEREN postcode: 8952 website: www.insphero.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (SCHLIEREN)	participant	0.00
41	MEDICAL RESEARCH COUNCIL MEDICAL RESEARCH COUNCIL Organization address address: NORTH STAR AVENUE POLARIS HOUSE 2 FLOOR DAVID PHILLIPS BUILDING city: SWINDON postcode: SN2 1FL website: www.mrc.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (SWINDON)	participant	0.00

Map

Project objective

The vision of EU-ToxRisk is to drive a paradigm shift in toxicology towards an animal-free, mechanism-based integrated approach to chemical safety assessment. The project will unite all relevant disciplines and stakeholders to establish: i) pragmatic, solid read-across procedures incorporating mechanistic and toxicokinetic knowledge; and ii) ab initio hazard and risk assessment strategies of chemicals with little background information. The project will focus on repeated dose systemic toxicity (liver, kidney, lung and nervous system) as well as developmental/reproduction toxicity. Different human tiered test systems are integrated to balance speed, cost and biological complexity. EU-ToxRisk extensively integrates the adverse outcome pathway (AOP)-based toxicity testing concept. Therefore, advanced technologies, including high throughput transcriptomics, RNA interference, and high throughput microscopy, will provide quantitative and mechanistic underpinning of AOPs and key events (KE). The project combines in silico tools and in vitro assays by computational modelling approaches to provide quantitative data on the activation of KE of AOP. This information, together with detailed toxicokinetics data, and in vitro-in vivo extrapolation algorithms forms the basis for improved hazard and risk assessment. The EU-ToxRisk work plan is structured along a broad spectrum of case studies, driven by the cosmetics, (agro)-chemical, pharma industry together with regulators. The approach involves iterative training, testing, optimization and validation phases to establish fit-for-purpose integrated approaches to testing and assessment with key EU-ToxRisk methodologies. The test systems will be combined to a flexible service package for exploitation and continued impact across industry sectors and regulatory application. The proof-of-concept for the new mechanism-based testing strategy will make EU-ToxRisk the flagship in Europe for animal-free chemical safety assessment.

Deliverables

List of deliverables.
Mapping ToxCast data to AOPs	Documents, reports	2020-04-06 10:11:10
AOPs and key events for adverse effects	Documents, reports	2020-04-06 10:11:10
Compound reference information resources	Documents, reports	2020-04-06 10:11:09

Take a look to the deliverables list in detail: detailed list of EU-ToxRisk deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2017	Alla P. Toropova, Andrey A. Toropov Hybrid optimal descriptors as a tool to predict skin sensitization in accordance to OECD principles published pages: 57-66, ISSN: 0378-4274, DOI: 10.1016/j.toxlet.2017.03.023	Toxicology Letters 275	2020-04-06
2017	Liudmila Efremova, Petra Chovancova, Martina Adam, Simon Gutbier, Stefan Schildknecht, Marcel Leist Switching from astrocytic neuroprotection to neurodegeneration by cytokine stimulation published pages: 231-246, ISSN: 0340-5761, DOI: 10.1007/s00204-016-1702-2	Archives of Toxicology 91/1	2020-04-06
2016	Isoude A. Kuijper, Huan Yang, Bob Van De Water, Joost B. Beltman Unraveling cellular pathways contributing to drug-induced liver injury by dynamical modeling published pages: 5-17, ISSN: 1742-5255, DOI: 10.1080/17425255.2017.1234607	Expert Opinion on Drug Metabolism & Toxicology 13/1	2020-04-06
2016	Olivier Taboureau Human Environmental Disease Network: A computational model to assess toxicology of contaminants published pages: , ISSN: 1868-596X, DOI: 10.14573/altex.1607201	ALTEX	2020-04-06
2017	Tanja Waldmann, Marianna Grinberg, AndrÃ© KÃ¶nig, Eugen Rempel, Stefan Schildknecht, Margit Henry, Anna-Katharina Holzer, Nadine Dreser, Vaibhav Shinde, Agapios Sachinidis, JÃ¶rg RahnenfÃ¼hrer, Jan G. Hengstler, Marcel Leist Stem Cell Transcriptome Responses and Corresponding Biomarkers That Indicate the Transition from Adaptive Responses to Cytotoxicity published pages: 905-922, ISSN: 0893-228X, DOI: 10.1021/acs.chemrestox.6b00259	Chemical Research in Toxicology 30/4	2020-04-06
2016	Thomas Luechtefeld Analysis of publically available skin sensitization data from REACH registrations 2008-2014 published pages: , ISSN: 1868-596X, DOI: 10.14573/altex.1510055	ALTEX	2020-04-06
2016	Fabiola Pizzo, Anna Lombardo, Alberto Manganaro, Emilio Benfenati A New Structure-Activity Relationship (SAR) Model for Predicting Drug-Induced Liver Injury, Based on Statistical and Expert-Based Structural Alerts published pages: , ISSN: 1663-9812, DOI: 10.3389/fphar.2016.00442	Frontiers in Pharmacology 7	2020-04-06
2017	JoÃ£o V. SÃ¡, Susanne Kleiderman, Catarina Brito, Ursula Sonnewald, Marcel Leist, Ana P. Teixeira, Paula M. Alves Quantification of Metabolic Rearrangements During Neural Stem Cells Differentiation into Astrocytes by Metabolic Flux Analysis published pages: 244-253, ISSN: 0364-3190, DOI: 10.1007/s11064-016-1907-z	Neurochemical Research 42/1	2020-04-06
2016	Thomas Luechtefeld Analysis of public oral toxicity data from REACH registrations 2008-2014 published pages: , ISSN: 1868-596X, DOI: 10.14573/altex.1510054	ALTEX	2020-04-06
2017	Alejandro Aguayo-Orozco, Karine Audouze, Soren Brunak, Olivier Taboureau In Silico Systems Pharmacology to Assess Drug\'s Therapeutic and Toxic Effects published pages: 6895-6902, ISSN: 1381-6128, DOI: 10.2174/1381612822666160907093215	Current Pharmaceutical Design 22/46	2020-04-06
2017	Steven Wink, Steven Hiemstra, Bram Herpers, Bob van de Water High-content imaging-based BAC-GFP toxicity pathway reporters to assess chemical adversity liabilities published pages: 1367-1383, ISSN: 0340-5761, DOI: 10.1007/s00204-016-1781-0	Archives of Toxicology 91/3	2020-04-06
2017	BÃ©la Z. Schmidt, Martin Lehmann, Simon Gutbier, Erastus Nembo, Sabrina Noel, Lena Smirnova, Anna Forsby, JÃ¼rgen Hescheler, Hasan X. Avci, Thomas Hartung, Marcel Leist, Julianna KobolÃ¡k, AndrÃ¡s DinnyÃ©s In vitro acute and developmental neurotoxicity screening: an overview of cellular platforms and high-throughput technical possibilities published pages: 1-33, ISSN: 0340-5761, DOI: 10.1007/s00204-016-1805-9	Archives of Toxicology 91/1	2020-04-06
2016	Hao Zhu Supporting read-across using biological data published pages: , ISSN: 1868-596X, DOI: 10.14573/altex.1601252	ALTEX	2020-04-06
2017	Andrey A. Toropov, Alla P. Toropova The index of ideality of correlation: A criterion of predictive potential of QSPR/QSAR models? published pages: 31-37, ISSN: 1383-5718, DOI: 10.1016/j.mrgentox.2017.05.008	Mutation Research/Genetic Toxicology and Environmental Mutagenesis 819	2020-04-06
2016	David Pamies Good Cell Culture Practice for stem cells and stem-cell-derived models published pages: , ISSN: 1868-596X, DOI: 10.14573/altex.1607121	ALTEX	2020-04-06
2017	Alla P. Toropova, Andrey A. Toropov The index of ideality of correlation: A criterion of predictability of QSAR models for skin permeability? published pages: 466-472, ISSN: 0048-9697, DOI: 10.1016/j.scitotenv.2017.01.198	Science of The Total Environment 586	2020-04-06
2016	Vaibhav Shinde, Sureshkumar Perumal Srinivasan, Margit Henry, Tamara Rotshteyn, JÃ¼rgen Hescheler, JÃ¶rg RahnenfÃ¼hrer, Marianna Grinberg, Johannes Meisig, Nils BlÃ¼thgen, Tanja Waldmann, Marcel Leist, Jan Georg Hengstler, Agapios Sachinidis Comparison of a teratogenic transcriptome-based predictive test based on human embryonic versus inducible pluripotent stem cells published pages: , ISSN: 1757-6512, DOI: 10.1186/s13287-016-0449-2	Stem Cell Research & Therapy 7/1	2020-04-06
2017	Vaibhav Shinde, Lisa Hoelting, Sureshkumar Perumal Srinivasan, Johannes Meisig, Kesavan Meganathan, Smita Jagtap, Marianna Grinberg, Julia Liebing, Nils Bluethgen, JÃ¶rg RahnenfÃ¼hrer, Eugen Rempel, Regina Stoeber, Stefan Schildknecht, Sunniva FÃ¶rster, Patricio Godoy, Christoph van Thriel, John Antonydas Gaspar, JÃ¼rgen Hescheler, Tanja Waldmann, Jan G. Hengstler, Marcel Leist, Agapios Sachinidis Definition of transcriptome-based indices for quantitative characterization of chemically disturbed stem cell development: introduction of the STOP-Toxukn and STOP-Toxukk tests published pages: 839-864, ISSN: 0340-5761, DOI: 10.1007/s00204-016-1741-8	Archives of Toxicology 91/2	2020-04-06
2016	Johanna Nyffeler Design of a high-throughput human neural crest cell migration assay to indicate potential developmental toxicants published pages: , ISSN: 1868-596X, DOI: 10.14573/altex.1605031	ALTEX	2020-04-06
2016	Lisa Hoelting, Stefanie Klima, Christiaan Karreman, Marianna Grinberg, Johannes Meisig, Margit Henry, Tamara Rotshteyn, JÃ¶rg RahnenfÃ¼hrer, Nils BlÃ¼thgen, Agapios Sachinidis, Tanja Waldmann, Marcel Leist Stem Cell-Derived Immature Human Dorsal Root Ganglia Neurons to Identify Peripheral Neurotoxicants published pages: 476-487, ISSN: 2157-6564, DOI: 10.5966/sctm.2015-0108	STEM CELLS Translational Medicine 5/4	2020-04-06
2016	J. Meiser, S. Delcambre, A. Wegner, C. JÃ¤ger, J. Ghelfi, A. Fouquier d\'Herouel, X. Dong, D. Weindl, C. Stautner, Y. Nonnenmacher, A. Michelucci, O. Popp, F. Giesert, S. Schildknecht, L. KrÃ¤mer, J.G. Schneider, D. Woitalla, W. Wurst, A. Skupin, D.M. Vogt Weisenhorn, R. KrÃ¼ger, M. Leist, K. Hiller Loss of DJ-1 impairs antioxidant response by altered glutamine and serine metabolism published pages: 112-125, ISSN: 0969-9961, DOI: 10.1016/j.nbd.2016.01.019	Neurobiology of Disease 89	2020-04-06
2017	Alla P. Toropova, Andrey A. Toropov CORAL: Binary classifications (active/inactive) for drug-induced liver injury published pages: 51-57, ISSN: 0378-4274, DOI: 10.1016/j.toxlet.2017.01.011	Toxicology Letters 268	2020-04-06
2017	Christopher Goldring, Daniel J. Antoine, Frank Bonner, Jonathan Crozier, Chris Denning, Robert J. Fontana, Neil A. Hanley, David C. Hay, Magnus Ingelman-Sundberg, Satu Juhila, Neil Kitteringham, Beatriz Silva-Lima, Alan Norris, Chris Pridgeon, James A. Ross, Rowena Sison Young, Danilo Tagle, Belen Tornesi, Bob van de Water, Richard J. Weaver, Fang Zhang, B. Kevin Park Stem cell-derived models to improve mechanistic understanding and prediction of human drug-induced liver injury published pages: 710-721, ISSN: 0270-9139, DOI: 10.1002/hep.28886	Hepatology 65/2	2020-04-06
2016	Thomas Luechtefeld Global analysis of publicly available safety data for 9,801 substances registered under REACH from 2008-2014 published pages: , ISSN: 1868-596X, DOI: 10.14573/altex.1510052	ALTEX	2020-04-06
2017	Colin Ockleford, Paulien Adriaanse, Philippe Berny, Theodorus Brock, Sabine Duquesne, Sandro Grilli, Antonio F Hernandezâ€Jerez, Susanne Hougaard Bennekou, Michael Klein, Thomas Kuhl, Ryszard Laskowski, Kyriaki Machera, Olavi Pelkonen, Silvia Pieper, Rob Smith, Michael Stemmer, Ingvar Sundh, Ivana Teodorovic, Aaldrik Tiktak, Chris J Topping, Gerrit Wolterink, Karine Angeli, Ellen Fritsche, Antonio F Hernandezâ€Jerez, Marcel Leist, Alberto Mantovani, Pablo Menendez, Olavi Pelkonen, Anna Price, Barbara Viviani, Arianna Chiusolo, Federica Ruffo, Andrea Terron, Susanne Hougaard Bennekou Investigation into experimental toxicological properties of plant protection products having a potential link to Parkinson\'s disease and childhood leukaemiaâ€ published pages: , ISSN: 1831-4732, DOI: 10.2903/j.efsa.2017.4691	EFSA Journal 15/3	2020-04-06
2016	Nicholas Ball Toward Good Read-Across Practice (GRAP) guidance published pages: , ISSN: 1868-596X, DOI: 10.14573/altex.1601251	ALTEX	2020-04-06
2016	Thomas Luechtefeld Analysis of Draize eye irritation testing and its prediction by mining publicly available 2008-2014 REACH data published pages: , ISSN: 1868-596X, DOI: 10.14573/altex.1510053	ALTEX	2020-04-06
2017	Cordula Hirsch, Britta Striegl, Stephanie Mathes, Christian Adlhart, Michael Edelmann, Epifania Bono, Sabyasachi Gaan, Khalifah A. Salmeia, Lisa Hoelting, Alice Krebs, Johanna Nyffeler, Regina Pape, Alexander BÃ¼rkle, Marcel Leist, Peter Wick, Stefan Schildknecht Multiparameter toxicity assessment of novel DOPO-derived organophosphorus flame retardants published pages: 407-425, ISSN: 0340-5761, DOI: 10.1007/s00204-016-1680-4	Archives of Toxicology 91/1	2020-04-06
2017	Peter L.M. Jansen, Ahmed Ghallab, Nachiket Vartak, Raymond Reif, Frank G. Schaap, Jochen Hampe, Jan G. Hengstler The ascending pathophysiology of cholestatic liver disease published pages: 722-738, ISSN: 0270-9139, DOI: 10.1002/hep.28965	Hepatology 65/2	2020-04-06
2016	Mardas Daneshian, Hennicke Kamp, Jan Hengstler, Marcel Leist, Bob van de Water Highlight report: Launch of a large integrated European in vitro toxicology project: EU-ToxRisk published pages: 1021-1024, ISSN: 0340-5761, DOI: 10.1007/s00204-016-1698-7	Archives of Toxicology 90/5	2020-04-06
2017	Johanna Nyffeler, Xenia Dolde, Alice Krebs, Kevin Pinto-Gil, Manuel Pastor, Mamta Behl, Tanja Waldmann, Marcel Leist Combination of multiple neural crest migration assays to identify environmental toxicants from a proof-of-concept chemical library published pages: , ISSN: 0340-5761, DOI: 10.1007/s00204-017-1977-y	Archives of Toxicology	2020-04-06
2016	Michael Aschner Reference compounds for alternative test methods to indicate developmental neurotoxicity (DNT) potential of chemicals: example lists and criteria for their selection and use published pages: , ISSN: 1868-596X, DOI: 10.14573/altex.1604201	ALTEX	2020-04-06
2016	Abinaya Chandrasekaran, Hasan X. Avci, Marcel Leist, Julianna KobolÃ¡k, Andras DinnyÃ©s Astrocyte Differentiation of Human Pluripotent Stem Cells: New Tools for Neurological Disorder Research published pages: , ISSN: 1662-5102, DOI: 10.3389/fncel.2016.00215	Frontiers in Cellular Neuroscience 10	2020-04-06
2017	Alla P. Toropova, Andrey A. Toropov, Marco Marzo, Sylvia E. Escher, Jean Lou Dorne, Nikolaos Georgiadis, Emilio Benfenati The application of new HARD-descriptor available from the CORAL software to building up NOAEL models published pages: , ISSN: 0278-6915, DOI: 10.1016/j.fct.2017.03.060	Food and Chemical Toxicology	2020-04-06
2018	Thomas Luechtefeld, Dan Marsh, Craig Rowlands, Thomas Hartung Machine Learning of Toxicological Big Data Enables Read-Across Structure Activity Relationships (RASAR) Outperforming Animal Test Reproducibility published pages: 198-212, ISSN: 1096-6080, DOI: 10.1093/toxsci/kfy152	Toxicological Sciences 165/1	2020-04-06
2018	Domenico Gadaleta, Anna Lombardo, Cosimo Toma, Emilio Benfenati A new semi-automated workflow for chemical data retrieval and quality checking for modeling applications published pages: , ISSN: 1758-2946, DOI: 10.1186/s13321-018-0315-6	Journal of Cheminformatics 10/1	2020-04-06
2018	Domenico Gadaleta, Serena Manganelli, Alessandra Roncaglioni, Cosimo Toma, Emilio Benfenati, Enrico Mombelli QSAR Modeling of ToxCast Assays Relevant to the Molecular Initiating Events of AOPs Leading to Hepatic Steatosis published pages: 1501-1517, ISSN: 1549-9596, DOI: 10.1021/acs.jcim.8b00297	Journal of Chemical Information and Modeling 58/8	2020-04-06
2018	Simon Gutbier, Patrick May, Sylvie Berthelot, Abhimanyu Krishna, Timo Trefzer, Mehri Behbehani, Liudmila Efremova, Johannes Delp, Gerhard Gstraunthaler, Tanja Waldmann, Marcel Leist Major changes of cell function and toxicant sensitivity in cultured cells undergoing mild, quasi-natural genetic drift published pages: 3487-3503, ISSN: 0340-5761, DOI: 10.1007/s00204-018-2326-5	Archives of Toxicology 92/12	2020-04-06
2018	Charles Laroche, Manoj Aggarwal, Hans Bender, Paul Benndorf, Barbara Birk, Jonathan Crozier, Gianni Dal Negro, Federica De Gaetano, Christian Desaintes, Iain Gardner, Bruno Hubesch, Amaia Irizar, David John, Vikas Kumar, Alfonso Lostia, Irene Manou, Mario Monshouwer, Boris P. MÃ¼ller, Alicia Paini, Kirsty Reid, Timothy Rowan, Magdalini Sachana, Katrin Schutte, Catrina Stirling, Rob Taalman, Leon van Aerts, Renate Weissenhorn, Ursula G. Sauer Finding synergies for 3Rs â€“ Toxicokinetics and read-across: Report from an EPAA partners\' Forum published pages: 5-21, ISSN: 0273-2300, DOI: 10.1016/j.yrtph.2018.08.006	Regulatory Toxicology and Pharmacology 99	2020-04-06
2018	Alejandro Aguayo-Orozco, Frederic Yves Bois, SÃ¸ren Brunak, Olivier Taboureau Analysis of Time-Series Gene Expression Data to Explore Mechanisms of Chemical-Induced Hepatic Steatosis Toxicity published pages: , ISSN: 1664-8021, DOI: 10.3389/fgene.2018.00396	Frontiers in Genetics 9	2020-04-06
2018	Johannes Delp A high-throughput approach to identify specific neurotoxicants / developmental toxicants in human neuronal cell function assays published pages: 235-253, ISSN: 1868-596X, DOI: 10.14573/altex.1712182	ALTEX	2020-04-06
2018	Steven Wink, Steven W. Hiemstra, Suzanne Huppelschoten, Janna E. Klip, Bob van de Water Dynamic imaging of adaptive stress response pathway activation for prediction of drug induced liver injury published pages: 1797-1814, ISSN: 0340-5761, DOI: 10.1007/s00204-018-2178-z	Archives of Toxicology 92/5	2020-04-06
2018	Xiaolong Gu, Wiebke Albrecht, Karolina Edlund, Franziska Kappenberg, JÃ¶rg RahnenfÃ¼hrer, Marcel Leist, Wolfgang Moritz, Patricio Godoy, Cristina Cadenas, Rosemarie Marchan, Tim Brecklinghaus, Laia Tolosa Pardo, JosÃ© V. Castell, Iain Gardner, Bo Han, Jan G. Hengstler, Regina Stoeber Relevance of the incubation period in cytotoxicity testing with primary human hepatocytes published pages: 3505-3515, ISSN: 0340-5761, DOI: 10.1007/s00204-018-2302-0	Archives of Toxicology 92/12	2020-04-06
2018	Andrea Terron, Anna Bal-Price, Alicia Paini, Florianne Monnet-Tschudi, Susanne Hougaard Bennekou, Marcel Leist, Stefan Schildknecht An adverse outcome pathway for parkinsonian motor deficits associated with mitochondrial complex I inhibition published pages: 41-82, ISSN: 0340-5761, DOI: 10.1007/s00204-017-2133-4	Archives of Toxicology 92/1	2020-04-06
2018	Georgina Harris, Melanie Eschment, Sebastian Perez Orozco, J. Michael McCaffery, Richard Maclennan, Daniel Severin, Marcel Leist, Andre Kleensang, David Pamies, Alexandra Maertens, Helena T. Hogberg, Dana Freeman, Alfredo Kirkwood, Thomas Hartung, Lena Smirnova Toxicity, recovery, and resilience in a 3D dopaminergic neuronal in vitro model exposed to rotenone published pages: 2587-2606, ISSN: 0340-5761, DOI: 10.1007/s00204-018-2250-8	Archives of Toxicology 92/8	2020-04-06
2019	Ian M. Copple, Wouter den Hollander, Giulia Callegaro, Fiona E. Mutter, James L. Maggs, Amy L. Schofield, Lucille Rainbow, Yongxiang Fang, Jeffrey J. Sutherland, Ewa C. Ellis, Magnus Ingelman-Sundberg, Stephen W. Fenwick, Christopher E. Goldring, Bob van de Water, James L. Stevens, B. Kevin Park Characterisation of the NRF2 transcriptional network and its response to chemical insult in primary human hepatocytes: implications for prediction of drug-induced liver injury published pages: 385-399, ISSN: 0340-5761, DOI: 10.1007/s00204-018-2354-1	Archives of Toxicology 93/2	2020-04-06
2018	Johanna Nyffeler, Petra Chovancova, Xenia Dolde, Anna-Katharina Holzer, Vladimir Purvanov, Ilona Kindinger, Anna Kerins, David Higton, Steve Silvester, Barbara M. A. van Vugt-Lussenburg, Enrico Glaab, Bart van der Burg, Richard Maclennan, Daniel F. Legler, Marcel Leist A structureâ€“activity relationship linking non-planar PCBs to functional deficits of neural crest cells: new roles for connexins published pages: 1225-1247, ISSN: 0340-5761, DOI: 10.1007/s00204-017-2125-4	Archives of Toxicology 92/3	2020-04-06
2018	Stephanie K. Bopp, Robert Barouki, Werner Brack, Silvia Dalla Costa, Jean-Lou C.M. Dorne, Paula E. Drakvik, Michael Faust, Tuomo K. Karjalainen, Stylianos Kephalopoulos, Jacob van Klaveren, Marike Kolossa-Gehring, Andreas Kortenkamp, Erik Lebret, Teresa Lettieri, Sofie NÃ¸rager, JoÃ«lle RÃ¼egg, Jose V. Tarazona, Xenia Trier, Bob van de Water, Jos van Gils, Ã…ke Bergman Current EU research activities on combined exposure to multiple chemicals published pages: 544-562, ISSN: 0160-4120, DOI: 10.1016/j.envint.2018.07.037	Environment International 120	2020-04-06
2018	Alice Limonciel, Gamze Ates, Giada Carta, Anja Wilmes, Manfred Watzele, Peter J. Shepard, Harper C. VanSteenhouse, Bruce Seligmann, Joanne M. Yeakley, Bob van de Water, Mathieu Vinken, Paul Jennings Comparison of base-line and chemical-induced transcriptomic responses in HepaRG and RPTEC/TERT1 cells using TempO-Seq published pages: 2517-2531, ISSN: 0340-5761, DOI: 10.1007/s00204-018-2256-2	Archives of Toxicology 92/8	2020-04-06
2017	Giorgia Pallocca, Johanna Nyffeler, Xenia Dolde, Marianna Grinberg, Gerhard Gstraunthaler, Tanja Waldmann, JÃ¶rg RahnenfÃ¼hrer, Agapios Sachinidis, Marcel Leist Impairment of human neural crest cell migration by prolonged exposure to interferon-beta published pages: 3385-3402, ISSN: 0340-5761, DOI: 10.1007/s00204-017-1966-1	Archives of Toxicology 91/10	2020-04-06
2019	Luc J. M. Bischoff, Isoude A. Kuijper, Johannes P. Schimming, Liesanne Wolters, Bas ter Braak, Jan P. Langenberg, Daan Noort, Joost B. Beltman, Bob van de Water A systematic analysis of Nrf2 pathway activation dynamics during repeated xenobiotic exposure published pages: 435-451, ISSN: 0340-5761, DOI: 10.1007/s00204-018-2353-2	Archives of Toxicology 93/2	2020-04-06
2018	Elias Zgheib, Alice Limonciel, Xiaoqi Jiang, Anja Wilmes, Steven Wink, Bob van de Water, Annette Kopp-Schneider, Frederic Y. Bois, Paul Jennings Investigation of Nrf2, AhR and ATF4 Activation in Toxicogenomic Databases published pages: , ISSN: 1664-8021, DOI: 10.3389/fgene.2018.00429	Frontiers in Genetics 9	2020-04-06
2019	Jaffar Kisitu Chemical concentrations in cell culture compartments (C5) â€“ concentration definitions published pages: 154-160, ISSN: 1868-596X, DOI: 10.14573/altex.1901031	ALTEX 36/1	2020-04-06
2018	Niemeijer M, Hiemstra S, Wink S, den Hollander W, ter Braak B, van de Water B Systems microscopy approaches in unravelling and predicting drug-induced liver injury (DILI) published pages: 611-625, ISSN: , DOI:	Methods in Pharmacology and Toxicology	2020-04-06
2018	Domenico Gadaleta, Serena Manganelli, Alessandra Roncaglioni, Cosimo Toma, Emilio Benfenati, Enrico Mombelli QSAR Modeling of ToxCast Assays Relevant to the Molecular Initiating Events of AOPs Leading to Hepatic Steatosis published pages: 1501-1517, ISSN: 1549-9596, DOI: 10.1021/acs.jcim.8b00297	Journal of Chemical Information and Modeling 58/8	2020-04-06
2018	Thomas Luechtefeld, Dan Marsh, Craig Rowlands, Thomas Hartung Machine Learning of Toxicological Big Data Enables Read-Across Structure Activity Relationships (RASAR) Outperforming Animal Test Reproducibility published pages: 198-212, ISSN: 1096-6080, DOI: 10.1093/toxsci/kfy152	Toxicological Sciences 165/1	2020-04-06
2018	Alice Krebs Normalization of data for viability and relative cell function curves published pages: 268-271, ISSN: 1868-596X, DOI: 10.14573/1803231	ALTEX	2020-04-06
2018	Alice Limonciel, Simone G. van Breda, Xiaoqi Jiang, Gregory D. Tredwell, Anja Wilmes, Lydia Aschauer, Alexandros P. Siskos, Agapios Sachinidis, Hector C. Keun, Annette Kopp-Schneider, Theo M. de Kok, Jos C. S. Kleinjans, Paul Jennings Persistence of Epigenomic Effects After Recovery From Repeated Treatment With Two Nephrocarcinogens published pages: , ISSN: 1664-8021, DOI: 10.3389/fgene.2018.00558	Frontiers in Genetics 9	2020-04-06
2018	Mar Coll, Luis Perea, Ruben Boon, Sofia B. Leite, Julia VallverdÃº, Inge Mannaerts, Ayla Smout, Adil El Taghdouini, Delia Blaya, Daniel Rodrigo-Torres, Isabel Graupera, Beatriz Aguilar-Bravo, Christophe Chesne, Mustapha Najimi, Etienne Sokal, Juan JosÃ© Lozano, Leo A. van Grunsven, Catherine M. Verfaillie, Pau Sancho-Bru Generation of Hepatic Stellate Cells from Human Pluripotent Stem Cells Enables InÂ Vitro Modeling of Liver Fibrosis published pages: 101-113.e7, ISSN: 1934-5909, DOI: 10.1016/j.stem.2018.05.027	Cell Stem Cell 23/1	2020-04-06
2018	David Pamies Advanced Good Cell Culture Practice for human primary, stem cell-derived and organoid models as well as microphysiological systems published pages: 353-378, ISSN: 1868-596X, DOI: 10.14573/altex.1710081	ALTEX	2020-04-06
2018	C. Fisher, S. SimÃ©on, M. Jamei, I. Gardner, Y.F. Bois VIVD: Virtual in vitro distribution model for the mechanistic prediction of intracellular concentrations of chemicals in in vitro toxicity assays published pages: , ISSN: 0887-2333, DOI: 10.1016/j.tiv.2018.12.017	Toxicology in Vitro	2020-04-06
2018	C.P. Fisher, O. Hatley, B. van Vugt, F. Bois, S. Escher, I. Gardner In Vitro to in vivo extrapolation of valproic acid hepatotoxicity: A biokinetic and physiologically based toxicokinetic informed approach published pages: S246, ISSN: 0378-4274, DOI: 10.1016/j.toxlet.2018.06.1015	Toxicology Letters 295	2020-04-06
2017	Ugis Sarkans, Mikhail Gostev, Awais Athar, Ehsan Behrangi, Olga Melnichuk, Ahmed Ali, Jasmine Minguet, Juan Camillo Rada, Catherine Snow, Andrew Tikhonov, Alvis Brazma, Johanna McEntyre The BioStudies databaseâ€”one stop shop for all data supporting a life sciences study published pages: D1266-D1270, ISSN: 0305-1048, DOI: 10.1093/nar/gkx965	Nucleic Acids Research 46/D1	2020-04-06
2018	Angela Oppelt, Daniel Kaschek, Suzanna Huppelschoten, Rowena Sison-Young, Fang Zhang, Marie Buck-Wiese, Franziska Herrmann, Sebastian Malkusch, Carmen L. KrÃ¼ger, Mara Meub, Benjamin Merkt, Lea Zimmermann, Amy Schofield, Robert P. Jones, Hassan Malik, Marcel Schilling, Mike Heilemann, Bob van de Water, Christopher E. Goldring, B. Kevin Park, Jens Timmer, Ursula KlingmÃ¼ller Model-based identification of TNFÎ±-induced IKKÎ²-mediated and IÎºBÎ±-mediated regulation of NFÎºB signal transduction as a tool to quantify the impact of drug-induced liver injury compounds published pages: , ISSN: 2056-7189, DOI: 10.1038/s41540-018-0058-z	npj Systems Biology and Applications 4/1	2020-04-06
2018	Megan Chesnut Regulatory acceptance of read-across published pages: 413-419, ISSN: 1868-596X, DOI: 10.14573/altex.1805081	ALTEX	2020-04-06
2018	M. Pastor, G.J.P. Westen, J.C. GÃ³mez-Tamayo, B.E. Lenselink, C.-C. Lam, B. Water, U. Norinder, S. Manganelli, D. Gadaleta, A. Roncaglioni Development and validation of computational models for predicting oxidative stress responses using comprehensive series of drug-like compounds published pages: S62-S63, ISSN: 0378-4274, DOI: 10.1016/j.toxlet.2018.06.062	Toxicology Letters 295	2020-04-06
2018	Johannes Delp, Simon Gutbier, Martin Cerff, Christin Zasada, Sebastian NiedenfÃ¼hr, Liang Zhao, Lena Smirnova, Thomas Hartung, Hanna Borlinghaus, Falk Schreiber, JÃ¶rg Bergemann, Jochem GÃ¤tgens, Martin Beyss, Salah Azzouzi, Tanja Waldmann, Stefan Kempa, Katharina NÃ¶h, Marcel Leist Stage-specific metabolic features of differentiating neurons: Implications for toxicant sensitivity published pages: 64-80, ISSN: 0041-008X, DOI: 10.1016/j.taap.2017.12.013	Toxicology and Applied Pharmacology 354	2020-04-06
2019	Cosimo Toma, Domenico Gadaleta, Alessandra Roncaglioni, Andrey Toropov, Alla Toropova, Marco Marzo, Emilio Benfenati QSAR Development for Plasma Protein Binding: Influence of the Ionization State published pages: , ISSN: 0724-8741, DOI: 10.1007/s11095-018-2561-8	Pharmaceutical Research 36/2	2020-04-06
2018	Domenico Gadaleta, Anna Lombardo, Cosimo Toma, Emilio Benfenati A new semi-automated workflow for chemical data retrieval and quality checking for modeling applications published pages: , ISSN: 1758-2946, DOI: 10.1186/s13321-018-0315-6	Journal of Cheminformatics 10/1	2020-04-06
2018	Anna Bal-Price Recommendation on test readiness criteria for new approach methods in toxicology: Exemplified for developmental neurotoxicity published pages: 306-352, ISSN: 1868-596X, DOI: 10.14573/altex.1712081	ALTEX	2020-04-06
2018	Marvin Martens, Tim Verbruggen, Penny Nymark, Roland GrafstrÃ¶m, Lyle D. Burgoon, Hristo Aladjov, Fernando Torres AndÃ³n, Chris T. Evelo, Egon L. Willighagen Introducing WikiPathways as a Data-Source to Support Adverse Outcome Pathways for Regulatory Risk Assessment of Chemicals and Nanomaterials published pages: , ISSN: 1664-8021, DOI: 10.3389/fgene.2018.00661	Frontiers in Genetics 9	2020-04-06
2018	C. Mahony, R. Currie, G. Daston, N. Kleinstreuer, B. van de Water Highlight report: â€˜Big data in the 3Râ€™s: outlook and recommendationsâ€™, a roundtable summary published pages: 1015-1020, ISSN: 0340-5761, DOI: 10.1007/s00204-017-2145-0	Archives of Toxicology 92/2	2020-04-06
2018	Marcel Leist Essential components of methods papers published pages: 429-432, ISSN: 1868-596X, DOI: 10.14573/altex.1807031	ALTEX	2020-04-06
2018	Simon Gutbier, Anna-Sophie Spreng, Johannes Delp, Stefan Schildknecht, Christiaan Karreman, Ilinca Suciu, Thomas Brunner, Marcus Groettrup, Marcel Leist Prevention of neuronal apoptosis by astrocytes through thiol-mediated stress response modulation and accelerated recovery from proteotoxic stress published pages: 2101-2117, ISSN: 1350-9047, DOI: 10.1038/s41418-018-0229-x	Cell Death & Differentiation 25/12	2020-04-06

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