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CellViewer SIGNED

CellViewer: super-resolution systems microscopy to assess pluripotency and differentiation of stem cells at single cell level

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

CellViewer project word cloud

Explore the words cloud of the CellViewer project. It provides you a very rough idea of what is the project "CellViewer" about.

dynamic stimuli stemness microscopy corresponding sr protein multiple visualize output loci academia cell differentiation mrnas cellular cutting resolution mesc cellviewer experts spatial software era renewal gene mechanistic turn refer embryonic predictive shift nanoscale mescs throughput models edge technologies parallel cells amount disciplinary biological hardware internationally chromatin collect stem commit remodelling mrna proteins kinetics mechanisms input industry biology quantitative paradigm mouse team self single phenotypic uniquely suited super dna

Project "CellViewer" data sheet

The following table provides information about the project.

Coordinator	FUNDACIO CENTRE DE REGULACIO GENOMICA Organization address address: CARRER DOCTOR AIGUADER 88 city: BARCELONA postcode: 8003 website: www.crg.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Spain [ES]
Project website	http://www.cellviewer.eu/
Total cost	3˙988˙752 €
EC max contribution	3˙988˙752 € (100%)
Programme	1. H2020-EU.1.2.1. (FET Open)
Code Call	H2020-FETOPEN-2014-2015-RIA
Funding Scheme	RIA
Starting year	2016
Duration (year-month-day)	from 2016-02-01 to 2020-05-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	FUNDACIO CENTRE DE REGULACIO GENOMICA FUNDACIO CENTRE DE REGULACIO GENOMICA Organization address address: CARRER DOCTOR AIGUADER 88 city: BARCELONA postcode: 8003 website: www.crg.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (BARCELONA)	coordinator	2˙086˙668.00
2	THE HEBREW UNIVERSITY OF JERUSALEM THE HEBREW UNIVERSITY OF JERUSALEM Organization address address: EDMOND J SAFRA CAMPUS GIVAT RAM city: JERUSALEM postcode: 91904 website: www.huji.ac.il contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IL (JERUSALEM)	participant	792˙500.00
3	Idea Bio-Medical Ltd. Idea Bio-Medical Ltd. Organization address address: Prof. Bergman St. 2 city: Rehovot postcode: 76705 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IL (Rehovot)	participant	687˙500.00
4	FUNDACIO INSTITUT DE CIENCIES FOTONIQUES FUNDACIO INSTITUT DE CIENCIES FOTONIQUES Organization address address: AVINGUDA CARL FRIEDRICH GAUSS 3 city: Castelldefels postcode: 8860 website: www.icfo.eu contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (Castelldefels)	participant	293˙334.00
5	LABORATORY IMAGING SRO LABORATORY IMAGING SRO Organization address address: ZA DRAHOU 171/17 city: PRAHA postcode: 102 00 website: www.laboratory-imaging.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CZ (PRAHA)	participant	128˙750.00
6	EUROPEAN MOLECULAR BIOLOGY LABORATORY EUROPEAN MOLECULAR BIOLOGY LABORATORY Organization address address: Meyerhofstrasse 1 city: HEIDELBERG postcode: 69117 website: http://www.embl.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (HEIDELBERG)	participant	0.00

Map

Project objective

In this ambitious and multi-disciplinary proposal, we aim to develop new technologies that will allow us to visualize in single cells, in parallel and at the systems level, DNA, mRNAs and proteins with nanoscale resolution. We will refer to these novel technologies as the ‘CellViewer’: a unique cutting-edge high-throughput super-resolution (SR) microscopy approach (including new hardware and software development) to collect at high-resolution a large amount of spatial and dynamic information in single cells. ‘CellViewer’ will allow us to study the mechanisms of mouse embryonic stem cell (mESC) self-renewal and differentiation upon application of specific stimuli, as a specific test case. We will analyse in single cells with high throughput, DNA remodelling at multiple specific gene loci and their corresponding production, distribution and kinetics of mRNA and protein products. We will collect a large amount of dynamic and nanoscale spatial information that will lead us to build predictive models of the phenotypic output from specific input stimuli. In turn, we will be able to develop a mechanistic understanding of how mESCs maintain their stemness or commit to differentiation. The partners of CellViewer are internationally recognized experts from academia and industry in the fields of stem cell and chromatin biology, super-resolution microscopy, quantitative modelling of biological systems, and hardware and software development. This team as a whole is uniquely suited to bring Systems Biology into the era of single cell analysis, which will be a paradigm shift in the way cellular systems will be studied.

Deliverables

List of deliverables.
Quality plan	Documents, reports	2020-02-07 10:11:20
Project website	Websites, patent fillings, videos etc.	2020-02-07 10:11:20

Take a look to the deliverables list in detail: detailed list of CellViewer deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2016	Francesco Sottile, Francesco Aulicino, Ilda Theka & Maria Pia Cosma Mesenchymal stem cells generate distinct functional hybrids in vitro via cell fusion or entosis published pages: , ISSN: 2045-2322, DOI: 10.1038/srep36863	Scientific Reports	2020-02-07

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The information about "CELLVIEWER" are provided by the European Opendata Portal: CORDIS opendata.