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P450RESIST SIGNED

Understanding and exploiting the insect P450 resistome

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

P450RESIST project word cloud

Explore the words cloud of the P450RESIST project. It provides you a very rough idea of what is the project "P450RESIST" about.

opportunity toolkit family p450s drivers wp1 slow structure xenobiotics enzymes resistant crop conferring transgenics variety insecticides herbivore insights insect relatively explore metabolism tools natural themselves strategies characterise overcome protection anti alter expression ongoing despite consisting adaptive diagnostics exceptional toxin chemistry vivo molecular frequency synthetic genomics vitro function defence cytochrome binding superfamily workpackages cutting plants shown screening summary quantitative ubiquitous enzyme regulatory resistance wp metabolic interaction chemicals rare p450 evolve prevent determinants modulate throughput families gained model mediating breaking nature defend edge relative resistome insects epigenetics sustainable pest insecticide qualitative critical evolution

Project "P450RESIST" data sheet

The following table provides information about the project.

Coordinator	THE UNIVERSITY OF EXETER Organization address address: THE QUEEN'S DRIVE NORTHCOTE HOUSE city: EXETER postcode: EX4 4QJ website: www.ex.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Total cost	1˙975˙512 €
EC max contribution	1˙975˙512 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2014-CoG
Funding Scheme	ERC-COG
Starting year	2016
Duration (year-month-day)	from 2016-01-01 to 2020-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	THE UNIVERSITY OF EXETER THE UNIVERSITY OF EXETER Organization address address: THE QUEEN'S DRIVE NORTHCOTE HOUSE city: EXETER postcode: EX4 4QJ website: www.ex.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (EXETER)	coordinator	1˙949˙494.00
2	ROTHAMSTED RESEARCH LIMITED ROTHAMSTED RESEARCH LIMITED Organization address address: West Common city: HARPENDEN postcode: AL52JQ website: www.rothamsted.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (HARPENDEN)	participant	26˙017.00

Map

Project objective

Insect resistance to synthetic insecticides and the anti-herbivore defence chemicals produced by many plants is an ongoing challenge to sustainable pest management while also an exceptional model system to study adaptive evolution. The cytochrome P450s are a superfamily of enzymes that are ubiquitous in nature, and one of the most important enzyme families used by insects to defend themselves against natural and synthetic xenobiotics. Insects have been shown to evolve resistance through quantitative changes in P450 expression or via qualitative changes in P450s that alter metabolic activity. Despite their importance in conferring resistance the variety of regulatory changes that modulate P450 expression in resistant insects and their relative frequency/impact is not fully understood. Furthermore, although qualitative changes in insect P450s associated with resistance are relatively rare they represent a unique opportunity to characterise insecticide/toxin binding and identify the critical structure/function determinants of the P450/insect toxin interaction.

In this project I will exploit cutting-edge advances in genomics, epigenetics and transgenics to study the insect P450 resistome in three main workpackages:

WP-1: Will identify the molecular drivers of quantitative changes to insect P450s. WP-2: Will explore the role of qualitative changes in insect P450s in mediating resistance and identify structure/function determinants of insecticide metabolism. WP-3: Will exploit the knowledge gained in WP1/2 and from previous research to deliver a ‘P450 toolkit’ consisting of in vitro and in vivo screening tools, with which to identify resistance breaking chemistry, and high-throughput diagnostics for use in resistance management.

In summary this project will provide novel insights into this important enzyme family and provide tools that can be used to develop new products and strategies that slow, prevent, or overcome resistance and so ensure sustainable crop protection

Publications

List of publications.
year	authors and title	journal	last update
2018	Christoph T. Zimmer, William T. Garrood, Kumar Saurabh Singh, Emma Randall, Bettina Lueke, Oliver Gutbrod, Svend Matthiesen, Maxie Kohler, Ralf Nauen, T.G. Emyr Davies, Chris Bass Neofunctionalization of Duplicated P450 Genes Drives the Evolution of Insecticide Resistance in the Brown Planthopper published pages: 268-274.e5, ISSN: 0960-9822, DOI: 10.1016/j.cub.2017.11.060	Current Biology 28/2	2019-05-30
2018	Cristina Manjon, Bartlomiej J. Troczka, Marion Zaworra, Katherine Beadle, Emma Randall, Gillian Hertlein, Kumar Saurabh Singh, Christoph T. Zimmer, Rafael A. Homem, Bettina Lueke, Rebecca Reid, Laura Kor, Maxie Kohler, JÃ¼rgen Benting, Martin S. Williamson, T.G. Emyr Davies, Linda M. Field, Chris Bass, Ralf Nauen Unravelling the Molecular Determinants of Bee Sensitivity to Neonicotinoid Insecticides published pages: 1137-1143.e5, ISSN: 0960-9822, DOI: 10.1016/j.cub.2018.02.045	Current Biology 28/7	2019-05-30

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The information about "P450RESIST" are provided by the European Opendata Portal: CORDIS opendata.