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DMC-MALVEC SIGNED

Automated diagnostic platform, data management system and innovative communication tool, for improving the impact of malaria vector control interventions

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

DMC-MALVEC project word cloud

Explore the words cloud of the DMC-MALVEC project. It provides you a very rough idea of what is the project "DMC-MALVEC" about.

urgent resistance platform standardized game 500 representative good genotyping informed modern cover software collect societal lower causing decisions vector practices market teach africa deaths life exemplifying populations countries monitoring saharan ways stratified disease assays guidelines vast data interfaced successful ict made threatening automated answer expansion prerequisite diagnostic infection employs ddms mosquito solution entomological routine insecticides species queries substantially settings african id mosquitoes insecticide relies health individual integral profile status communicating organizing interactive multiplex labdisk custom malaria decision obstacles interpreting perform prevention store determinations interventions sub employed

Project "DMC-MALVEC" data sheet

The following table provides information about the project.

Coordinator	IDRYMA TECHNOLOGIAS KAI EREVNAS Organization address address: N PLASTIRA STR 100 city: IRAKLEIO postcode: 70013 website: www.forth.gr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Greece [EL]
Project website	http://www.dmc-malvec.eu/
Total cost	3˙167˙376 €
EC max contribution	2˙768˙001 € (87%)
Programme	1. H2020-EU.2.1.1. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies - Information and Communication Technologies (ICT))
Code Call	H2020-ICT-2015
Funding Scheme	RIA
Starting year	2016
Duration (year-month-day)	from 2016-02-01 to 2020-05-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	IDRYMA TECHNOLOGIAS KAI EREVNAS IDRYMA TECHNOLOGIAS KAI EREVNAS Organization address address: N PLASTIRA STR 100 city: IRAKLEIO postcode: 70013 website: www.forth.gr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	EL (IRAKLEIO)	coordinator	552˙066.00
2	LIVERPOOL SCHOOL OF TROPICAL MEDICINE LIVERPOOL SCHOOL OF TROPICAL MEDICINE Organization address address: Pembroke Place city: LIVERPOOL postcode: L35QA website: http://www.lstmliverpool.ac.uk/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LIVERPOOL)	participant	505˙355.00
3	HAHN-SCHICKARD-GESELLSCHAFT FUER ANGEWANDTE FORSCHUNG E.v. HAHN-SCHICKARD-GESELLSCHAFT FUER ANGEWANDTE FORSCHUNG E.v. Organization address address: WILHELM-SCHICKARD-STRASSE 10 city: Villingen postcode: 78052 website: www.hsg-imit.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (Villingen)	participant	403˙568.00
4	MINISTRY OF HEALTH MINISTRY OF HEALTH Organization address address: NDEKE HOUSE city: LUSAKA postcode: 10101 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ZM (LUSAKA)	participant	267˙523.00
5	Organisation de Coordination pour la lutte contre les Endémies en Afrique Centrale Organisation de Coordination pour la lutte contre les Endémies en Afrique Centrale Organization address address: Rue du Centre Pasteur 2007 city: Yaounde postcode: n.a. website: www.oceac.org contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CM (Yaounde)	participant	267˙500.00
6	JIMMA UNIVERSITY JIMMA UNIVERSITY Organization address address: JIMMA UNIVERSITY city: JIMMA postcode: n.a. website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ET (JIMMA)	participant	264˙598.00
7	FAST TRACK DIAGNOSTICS LUXEMBOURG SARL FAST TRACK DIAGNOSTICS LUXEMBOURG SARL Organization address address: RUE HENRI KOCH 29 city: ESCH SUR ALZETTE postcode: 4354 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	LU (ESCH SUR ALZETTE)	participant	251˙000.00
8	N.T. LABORATORY SRL N.T. LABORATORY SRL Organization address address: VIA BALDANZESE 35 city: CALENZANO postcode: 50041 website: www.ntlaboratory.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (CALENZANO)	participant	213˙888.00
9	GEOPONIKO PANEPISTIMION ATHINON GEOPONIKO PANEPISTIMION ATHINON Organization address address: IERA ODOS 75 city: ATHINA postcode: 118 55 website: www.aua.gr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	EL (ATHINA)	participant	42˙500.00
10	SCHWEIZERISCHES TROPEN- UND PUBLIC HEALTH-INSTITUT SCHWEIZERISCHES TROPEN- UND PUBLIC HEALTH-INSTITUT Organization address address: SOCINSTRASSE 57 city: Basel postcode: CH-4002 website: www.swisstph.ch contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (Basel)	participant	0.00

Map

Project objective

Malaria is a life-threatening disease causing more than 500,000 deaths every year in sub-Saharan Africa. Prevention of the disease is best achieved by vector control which relies on the use of insecticides. Monitoring mosquito vector populations is an integral component of control programmes and a prerequisite for effective interventions. Several individual methods are used for this task, However, there are obstacles to their uptake, as well as challenges in organizing, interpreting and communicating vector control data. We will develop a fully integrated and automated multiplex vector-diagnostic platform (LabDisk) for monitoring the species ID, the infection status of mosquitoes and the insecticide resistance profile of malaria vector populations. The system will provide sample-to-answer determinations, and it will perform genotyping at substantially lower cost, compared to the assays that are currently used in Africa. The LabDisk will be interfaced with a Disease Data Management System (DDMS), custom made data management software which will collect data from routine entomological monitoring activities, store, and make available stratified information based on “user queries” in a standardized way. The “GAME”, a modern ICT platform that employs interactive ways of communicating guidelines and exemplifying good practices of successful use of interventions in the health sector will be also employed, to teach operational end users the use of data to make informed decisions. The integrated system (LabDisk, DDMS & Game) will be implemented in four sub-Saharan African countries, highly representative of malaria settings and vector control problems, to support informed decision-making about vector control and disease management. It will cover the urgent needs of an existing “market” and will provide solution to end users, to address a most important societal challenge in Africa, the control of malaria. The system has a vast expansion potential in other applications.

Deliverables

List of deliverables.
Periodic report 1	Documents, reports	2020-03-17 11:53:55
Report on fluidic layouts	Documents, reports	2020-03-17 11:53:55
Second Report on communication activities	Documents, reports	2020-03-17 11:53:55
Validated GAME available for pilot implementation	Demonstrators, pilots, prototypes	2020-03-17 11:53:55
Second Annual plan for dissemination of information/knowledge and external communication	Documents, reports	2020-03-17 11:53:55
Third Annual newsletter	Websites, patent fillings, videos etc.	2020-03-17 11:53:55
Demo of LabDisk operation at lab scale	Demonstrators, pilots, prototypes	2020-03-17 11:53:55
DDMS configured and validated in Cameroon for collation of historical entomology data	Demonstrators, pilots, prototypes	2020-03-17 11:53:55
Report of lab testing of systems diagnostic performance	Documents, reports	2020-03-17 11:53:55
Second Annual newsletter	Websites, patent fillings, videos etc.	2020-03-17 11:53:55
Report on NA assay protocol (extraction and amplification)	Documents, reports	2020-03-17 11:53:54
TaqMan kits and lyophilised components are manufactured and delivered to partners	Other	2020-03-17 11:53:54
Exploitation Plan	Documents, reports	2020-03-17 11:53:54
First Annual newsletter	Websites, patent fillings, videos etc.	2020-03-17 11:53:55
Adapted and expanded GAME	Other	2020-03-17 11:53:54
Project website to support networking and information exchange	Websites, patent fillings, videos etc.	2020-03-17 11:53:55
Risk management plan	Documents, reports	2020-03-17 11:53:54
First Report on communication activities	Documents, reports	2020-03-17 11:53:54
Documented baseline information for the DDMS and GAME requirements	Documents, reports	2020-03-17 11:53:55
First Annual plan for dissemination	Documents, reports	2020-03-17 11:53:54
DDMS adapted to cater for gene expression data and analysis of pools of mosquito data	Other	2020-03-17 11:53:54
Agenda of the Startup meeting	Documents, reports	2020-03-17 11:53:54
Quality control handbook	Documents, reports	2020-03-17 11:53:55

Take a look to the deliverables list in detail: detailed list of DMC-MALVEC deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2018	Konstantinos Mitsakakis, Sebastian Hin, Pie MÃ¼ller, Nadja Wipf, Edward Thomsen, Michael Coleman, Roland Zengerle, John Vontas, Konstantinos Mavridis Converging Human and Malaria Vector Diagnostics with Data Management towards an Integrated Holistic One Health Approach published pages: 259, ISSN: 1660-4601, DOI: 10.3390/ijerph15020259	International Journal of Environmental Research and Public Health 15/2	2020-03-17
2018	Mary Kefi, Konstantinos Mavridis, Maria L. SimÃµes, George Dimopoulos, Inga Siden-Kiamos, John Vontas New rapid one-step PCR diagnostic assay for Plasmodium falciparum infective mosquitoes published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-19780-6	Scientific Reports 8/1	2020-03-17
2019	Konstantinos Mavridis, Nadja Wipf, Sandrine Medves, Ignacio Erquiaga, Pie MÃ¼ller, John Vontas Rapid multiplex gene expression assays for monitoring metabolic resistance in the major malaria vector Anopheles gambiae published pages: , ISSN: 1756-3305, DOI: 10.1186/s13071-018-3253-2	Parasites & Vectors 12/1	2020-03-17
2018	Konstantinos Mavridis, Nadja Wipf, Pie MÃ¼ller, Mohamed M. TraorÃ©, Gunter Muller, John Vontas Detection and Monitoring of Insecticide Resistance Mutations in Anopheles gambiae: Individual vs Pooled Specimens published pages: 479, ISSN: 2073-4425, DOI: 10.3390/genes9100479	Genes 9/10	2020-03-17

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