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BioExtrusion SIGNED

Natural functional plasticizers for controlled protein folding and extrusion into biomaterials.

Total Cost €

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EC-Contrib. €

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Partnership

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 BioExtrusion project word cloud

Explore the words cloud of the BioExtrusion project. It provides you a very rough idea of what is the project "BioExtrusion" about.

silk    answer    form    solution    secondment    stress    ing    with    structural    spiders    disciplines    natural    question    techniques    spin    ambient    chemistry    spun    aggregation    biopolymers    green    combining    conversion    sciences    raised    gland    small    converting    ph    succeeded    organic    environmental    molecular    fibre    polyphenol    supervised    transformation    experts    medical    holy    tackle    removal    sheet    first    successful    industrial    cold    luxilon    finely    biology    date    extended    soluble    nature    occurs    missing    spinning    removing    solid    whereby    data    ugent    expertise    formulate    hypothesis    proteins    polymer    tuned    beta    converted    never    company    impacting    protein    moths    pollution    polyphenolic    material    materials    hope    polymeric    social    time    compounds    water    answered    extrusion    quite    diseases    concentration    grail    molecules    global    align    alone    complementary    structures    induce    world    extruded    biomaterials    ion   

Project "BioExtrusion" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITEIT GENT 

Organization address
address: SINT PIETERSNIEUWSTRAAT 25
city: GENT
postcode: 9000
website: http://www.ugent.be

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Belgium [BE]
 Project website https://www.ugent.be/en/research/research-ugent/trackrecord/trackrecord-h2020/msca-h2020/msca-itn-bioextrusion.htm
 Total cost 160˙800 €
 EC max contribution 160˙800 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-05-01   to  2018-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITEIT GENT BE (GENT) coordinator 160˙800.00

Map

 Project objective

With a raised global awareness of industrial environmental pollution, the polymer research is focusing on green biopolymers. The spinning gland of spiders and silk moths is the holy grail in green extrusion, as silk is spun at ambient conditions and is water based. This is achieved by finely tuned spinning parameters in the silk gland (pH, ion concentration, stress and water removal), whereby the soluble silk solution is converted into a solid fibre. To date, no one has ever succeeded in spinning at these ambient conditions, used in the natural spinning system.

In this project, one missing spinning parameter will be investigated, namely small molecules, in the form of polyphenolic compounds, that are also extruded together with the silk. We formulate the hypothesis that these small molecules help to align and may even induce β-sheet aggregation by removing the water necessary for converting the silk protein solution into a solid fibre during spinning. As this same aggregation of proteins also occurs in many diseases, we will tackle this hypothesis with different techniques from quite different disciplines namely organic chemistry, structural-molecular biology and polymeric sciences. In this way we hope to answer our question that could never be answered by one field alone, as these disciplines will provide complementary data.

In a first phase, the polyphenol-induced conversion of proteins to β-sheet structures will be investigated, necessary for a successful transformation of a protein solution into a solid material, supervised by world-leading experts (UGent). In a second phase, this knowledge will be applied for the cold extrusion of protein-based materials in the secondment, a company Luxilon, with extended expertise in fibre extrusion technology. Combining the knowledge of both partners, will enable us to spin protein-based biomaterials like nature does for the first time, resulting in green extrusion, impacting the industrial, medical and social sector.

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The information about "BIOEXTRUSION" are provided by the European Opendata Portal: CORDIS opendata.

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