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STC SIGNED

Synaptic Tagging and Capture: From Synapses to Behavior

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 STC project word cloud

Explore the words cloud of the STC project. It provides you a very rough idea of what is the project "STC" about.

activation    transiently    populations    synaptic    stimuli    two    preceded    stabilized    color    caused    inducing    visual    fraction    temporal    stabilize    cellular    underlies    stc    divided    inputs    predictions    basis    capture    explicit    amygdala    selective    stabilization    capturing    tagging    followed    auditory    remarkably    tone    proteins    neurons    stable    circuit    foot    permits    naturally    potentiation    synthesis    made    induce    hypothesis    fear    examine    associative    engineer    ltp    animal    neuronal    stability    population    mechanism    proposes    tagged    optical    shown    associates    plasticity    events    model    explicitly    put    optogenetics    activated    formed    resolution    induction    predicts    memory    stimulus    optically    memories    manipulating    protein    precise    manipulation    it    natural    heterosynaptic    spatial    dependent    converging    grant    happening    shock    expression    forgotten    subsequently    optogenetic    small    inducible   

Project "STC" data sheet

The following table provides information about the project.

Coordinator
AARHUS UNIVERSITET 

Organization address
address: NORDRE RINGGADE 1
city: AARHUS C
postcode: 8000
website: www.au.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Total cost 1˙500˙000 €
 EC max contribution 1˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-STG
 Funding Scheme ERC-STG
 Starting year 2016
 Duration (year-month-day) from 2016-04-01   to  2021-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    AARHUS UNIVERSITET DK (AARHUS C) coordinator 1˙500˙000.00

Map

 Project objective

It is shown that long-term potentiation (LTP) is the cellular basis of memory formation. However, since all but small fraction of memories are forgotten, LTP has been further divided into early LTP (e-LTP), the mechanism by which short-term memories are formed, and a more stable late LTP (L-LTP), by which long-term memories are formed. Remarkably, it has been shown that an e-LTP can be stabilized if it is preceded or followed by heterosynaptic L-LTP. According to Synaptic Tagging and Capture (STC) hypothesis, e-LTP is stabilized by capturing proteins that are made by L-LTP induction. The model proposes that this mechanism underlies the formation of late associative memory, where the stability of a memory is not only defined by the stimuli that induce the change but also by events happening before and after these stimuli. As such, the model explicitly predicts that a short-term memory can be stabilized by inducing heterosynaptic L-LTP. In this grant, I will put this hypothesis into test. Specifically, I will test two explicit predictions of STC model: 1) A naturally formed short-term memory can be stabilized by induction of heterosynaptic L-LTP. 2) This stabilization is caused by the protein synthesis feature of L-LTP. To do this, using optogenetics, I will engineer a short-term memory in auditory fear circuit, in which an animal transiently associates a foot shock to a tone. Subsequently, I will examine if optogenetic delivery of L-LTP to the visual inputs converging on the same population of neurons in the amygdala will stabilize the short-term tone fear memory. To be able to engineer natural memory by manipulating synaptic plasticity I will develop two systems: 1) A two-color optical activation system which permits selective manipulation of distinct neuronal populations with precise temporal and spatial resolution; 2) An inducible and activity-dependent expression system by which those neurons that are activated by a natural stimulus will be optically tagged.

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The information about "STC" are provided by the European Opendata Portal: CORDIS opendata.

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