Opendata, web and dolomites
DASCE TERMINATED
Dissecting specific amygdala-striatal circuits for exploration
Total Cost €
0EC-Contrib. €
0Partnership
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0DASCE project word cloud
Explore the words cloud of the DASCE project. It provides you a very rough idea of what is the project "DASCE" about.
neurons
mechanism
moving
connected
evolution
optogenetic
functionally
survival
projection
classes
depression
unpredictable
specificity
multidisciplinary
multiple
unknown
animal
variability
projecting
environment
calcium
cell
disorders
technique
animals
explore
reveal
uncover
elusive
mammals
unfamiliar
starting
medial
brain
emotional
dependent
projections
gained
striatal
beneficial
intricate
imaging
implication
mice
neuronal
types
cure
overcome
fine
circumstances
learned
dorso
nature
exploring
collaborative
encoding
emotions
circuitries
employ
post
area
behavioral
hypothesized
actions
dictated
experiences
behavior
innate
caused
techniques
causally
familiar
surroundings
striatum
ensembles
variety
progression
exploratory
combination
compartment
strategies
psychiatric
behaviors
amygdala
computational
anxiety
directed
exact
gain
planning
Project "DASCE" data sheet
The following table provides information about the project.
| Coordinator |
FUNDACAO D. ANNA SOMMER CHAMPALIMAUD E DR. CARLOS MONTEZ CHAMPALIMAUD
Organization address contact info |
| Coordinator Country | Portugal [PT] |
| Total cost | 148˙635 € |
| EC max contribution | 148˙635 € (100%) |
| Programme |
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility) |
| Code Call | H2020-MSCA-IF-2015 |
| Funding Scheme | MSCA-IF-EF-ST |
| Starting year | 2017 |
| Duration (year-month-day) | from 2017-09-01 to 2019-08-31 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | FUNDACAO D. ANNA SOMMER CHAMPALIMAUD E DR. CARLOS MONTEZ CHAMPALIMAUD | PT (LISBOA) | coordinator | 148˙635.00 |
Map
Project objective
Survival and adaptation are dependent on an animal's ability to gain novel information in unfamiliar surroundings. Similar to other animal classes, mammals must use a variety of innate and learned exploratory strategies that are dictated by unpredictable or unknown circumstances. As the combination of emotional processes and planning of complex actions are essential for the development of such strategies, it can be hypothesized that strongly connected brain areas involved in emotions (the amygdala) and goal-directed behaviors (the dorso-medial striatum) have an implication on exploratory behavior. The intricate neuronal nature and brain area specificity in the controlling of such strategies, however, remain elusive. In order to functionally uncover the role of specific amygdala-striatal long-range projections in freely-exploring mice, our collaborative study will adopt a multidisciplinary approach by a) developing a multiple-compartment behavioral task to study the exact evolution of exploratory strategies in a novel environment starting from a familiar one, b) examining the neuronal encoding of amygdala-striatal projecting neurons during exploratory progression using a novel calcium imaging technique in freely-moving animals, and c) causally relating the role of pre- and post- neuronal ensembles to exploratory strategies applying a projection-specific optogenetic approach. Furthermore, the proposed project will employ state-of -the-art techniques to reveal the fine computational mechanism used by animals to explore their surroundings and to determine the neuronal encoding specific to brain-, cell- and projection-types. Our research will be beneficial not only for understanding the role of defined circuitries in behavioral variability caused by unpredictable circumstances and the ability to overcome these through the knowledge gained from past experiences, but also for the finding of a cure for complex psychiatric disorders including anxiety and depression.
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