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HeteroCancerInvasion SIGNED

Effect of heterogeneity of cancer cells on collective invasion

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

HeteroCancerInvasion project word cloud

Explore the words cloud of the HeteroCancerInvasion project. It provides you a very rough idea of what is the project "HeteroCancerInvasion" about.

invasiveness contains complication types hypothesis cells line live population invasion 3d lot invade mathematical movement assay careful editing cancer contrast nature metastasis gene collective tumour group strategies tissue either beneficial combine utilise recent single diverse imaging little demonstrated dissection causes configurations understand sum behavior phenotypically resolution heterogeneity documented intratumour limit heterogeneous adhesion retaining starting hypothesised cell

Project "HeteroCancerInvasion" data sheet

The following table provides information about the project.

Coordinator	THE FRANCIS CRICK INSTITUTE LIMITED Organization address address: 1 MIDLAND ROAD city: LONDON postcode: NW1 1AT website: www.crick.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Project website	https://www.crick.ac.uk/research/a-z-researchers/researchers-p-s/erik-sahai/
Total cost	195˙454 €
EC max contribution	195˙454 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2015
Funding Scheme	MSCA-IF-EF-ST
Starting year	2016
Duration (year-month-day)	from 2016-05-01 to 2018-04-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	THE FRANCIS CRICK INSTITUTE LIMITED THE FRANCIS CRICK INSTITUTE LIMITED Organization address address: 1 MIDLAND ROAD city: LONDON postcode: NW1 1AT website: www.crick.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	coordinator	195˙454.00

Map

Project objective

Recent live cell imaging studies have demonstrated that cancer cells invade either as single cell or as cell group retaining cell-cell adhesion. In contrast to the well-documented single cell movement, little is known about collective cancer cell invasion. Given that a single tumour tissue contains various types of cancer cells and the collective movement of cancer cells is sum of the behavior of phenotypically different cells, we hypothesised that intratumour heterogeneity affect collective invasiveness. Careful dissection of the movement of diverse cancer cells is required to study the nature of collective invasion because different behaviour of heterogeneous cancer cells causes complication to understand the movement of whole cancer cell collective. In this study we will utilise and combine the single-cell resolution live cell imaging of 3D collective invasion assay with different types of cancer cell line generated by gene editing and mathematical modelling of invasion assay, which enable us to set up a lot of different possible starting configurations, to test our hypothesis. This project not only advance our current understanding of collective invasion of heterogeneous cancer cell population, but also will be beneficial to design better strategies to limit the invasion and metastasis of cancer.

Publications

List of publications.
year	authors and title	journal	last update
2017	Anna Labernadie, Takuya Kato, AgustÃ BruguÃ©s, Xavier Serra-Picamal, Stefanie Derzsi, Esther Arwert, Anne Weston, Victor GonzÃ¡lez-TarragÃ³, Alberto Elosegui-Artola, Lorenzo Albertazzi, Jordi Alcaraz, Pere Roca-Cusachs, Erik Sahai, Xavier Trepat A mechanically active heterotypic E-cadherin/N-cadherin adhesion enables fibroblasts toÂ drive cancer cell invasion published pages: 224-237, ISSN: 1465-7392, DOI: 10.1038/ncb3478	Nature Cell Biology 19/3	2019-06-13

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