Opendata, web and dolomites

H2020 projects about "editing"

The page lists 227 projects related to the topic "editing".

# achronym  title  year 
1 realFlow Virtualization of Real Flows for Animation and Simulation 2015
2 NEURAL AS Functions and evolutionary impact of transcriptomic novelties in the vertebrate brain 2015
3 DISTRO Distributed 3D Object Design 2015
4 RNArepair Site-directed RNA Editing to Manipulate RNA and Protein Function 2015
5 Invisibilia Tracing the Invisible. Old Norse and Latin in medieval manuscripts. 2016
6 ICELANDIC SCRIBES Scribal networks in 17th-century Iceland: The patronage of Magnús Jónsson í Vigur 2016
7 NLRs Mechanisms of natural auto immunity triggered by plant NLR immune receptors 2015
8 EvoNovo Genetic architecture of an evolutionary novelty: the development of the male-specific turban-shaped eyes of Cloeon dipterum 2016
9 MELANOPARK Investigating the LRRK2-melanin connection through phosphoproteomics of isogenic melanoma cells 2015
10 WntTraffic Characterising the spatial organisation and regulation of the Wnt receptor complex in stem cells and cancer 2016
11 HepatoRiSK A new tumor suppressor role for RSK2 in hepatocellular carcinoma 2015
12 DUALgRENP A DUAL gRNA system for functional assessment of ENhancers in Pluripotency 2016
13 Unbabel Unbabel: Scalable, affordable and seamless content globalization using distributed crowd-post editing 2015
14 GY GameYourself - Create a virtual 3D model of a person’s face based on a short video taken with any smartphone cam. 2014
15 SONATA Service Programing and Orchestration for Virtualized Software Networks 2015
16 MIMIC Mimicking organs on chips for high throughput drug screening and basic research 2016
17 ALPS.INN3 Innovation Support Services for SMEs in North West Italy 2015
18 FLOWERPOWER Establishing a new generation of horticulturists: Multidisciplinary approach for breeding innovative novelties using classical and biotechnological methods 2016
19 UNEXPECTED Uncovering targets for ex vivo expansion of hematopoietic stem cells to enhance cell therapies of blood disorders 2015
20 ENLIGHT-TEN European Network linking informatics and genomics of helper T cells 2015
21 STEMCARDIORISK Stem Cells for Cardiac Arrhythmia Risk Assessment 2015
22 CVI_ADAPT Unraveling the history of adaptation in an island model: Cape Verde Arabidopsis 2015
23 RobustSynapses Maintaining synaptic function for a healthy brain: Membrane trafficking and autophagy in neurodegeneration 2016
24 XChromosome Functions of the X chromosome in the mammalian germ line 2015
25 SEED Learning to See in a Dynamic World 2016
26 RNAEDIT RNA EDITING IN HEALTH AND DISEASE 2016
27 ReaDMe Readout of DNA methylation 2016
28 EU-rhythmy Molecular strategies to treat inherited arrhythmias 2015
29 PlasmoSilencing Exoribonuclease-mediated degradation of nascent RNA in Malaria Parasites: A Novel Mechanism in Virulence Gene Silencing 2015
30 InVID In Video Veritas – Verification of Social Media Video Content for the News Industry 2016
31 DROSADAPTATION New approaches to long-standing questions: adaptation in Drosophila 2016
32 COSYN Comorbidity and Synapse Biology in Clinically Overlapping Psychiatric Disorders 2016
33 CFS modelling Chromosomal Common Fragile Sites: Unravelling their biological functions and the basis of their instability 2016
34 GROWTHPATTERN Coordination Of Patterning And Growth In The Spinal Cord 2016
35 SATBIOFUN Genome editing for spatiotemporal analysis of centriolar SATellite BIOgenesis and FUNction in cellular stress responses 2016
36 EVI1inCancer Overcoming the epigenetic and therapeutic barrier of EVI1-overexpressing cancers 2016
37 INTEGHER Integration of herpesvirus into telomeres: From the mechanism of genome integration and mobilization to therapeutic intervention 2016
38 G-EDIT Mechanisms of RNA-guided genome editing in eukaryotes 2016
39 NeuroASPECT Neuronal Alternative Splicing and RNA-Editing Crosstalk 2017
40 HairGen Genetics of human hair form diversity 2016
41 BIO-Banana IN and OUT BIO: Banana IN and OUT - engineering resistance against Panama disease in banana 2016
42 HeteroCancerInvasion Effect of heterogeneity of cancer cells on collective invasion 2016
43 CureCKDHeart Targeting perivascular myofibroblast progenitors to treat cardiac fibrosis and heart failure in chronic kidney disease 2016
44 CHAMELEON Intuitive editing of visual appearance from real-world datasets 2016
45 EpigenomeProgramming An experimental and bioinformatic toolbox for functional epigenomics and its application to epigenetically making and breaking a cancer cell 2016
46 REpiReg RNAi-mediated Epigenetic Gene Regulation 2017
47 SynthHotSpot Synthesizing Meiotic Crossover Hotspots in Arabidopsis 2016
48 CLIM Computational Light fields IMaging 2016
49 AcadHist Philodemus' History of the Academy: Groundwork for a New Innovative Critical Edition 2016
50 REPROHEAT Increasing reproductive success in crops under high ambient temperature 2017
51 EpiTarget Epigenome-targeted therapy for cholangiocarcinoma. 2017
52 DMD2CURE Correction of duplications in the DMD gene by a CRISPR/Cas9 approach 2017
53 ToxoPersist Molecular Basis of Toxoplasma gondii Encystation and Persistence 2016
54 MemoryDynamics Writing and editing of memories from acquisition to long-term consolidation 2016
55 MYCO TRAPS New roles for the cytoskeleton in cell-autonomous immunity to mycobacteria 2016
56 Reedsy Connecting authors and publishers with the world`s best publishing professionals to create high-quality books 2016
57 HRMECH Nucleases in homologous recombination: from basic principles to genome editing 2016
58 EYEGET Gene therapy of inherited retinal diseases 2017
59 BRCANCER A novel approach for modeling development of breast cancer 2016
60 MUYA The Multimedia Yasna 2016
61 MacAGE Macrophage aging and rejuvenation 2017
62 NASCENT Novel Approach to Systematically Characterize Exercise- and Nutrient- responsive genes in Type 2 diabetes and cardiovascular disease 2017
63 LADIO Live Action Data Input and Output 2016
64 DeMMYR Decoding the molecular mechanisms driving host adaptation of yellow rust on cereal crops and grasses 2017
65 PRODUCER PeRsOnalized DocUmentary Creation based on Automatically Annotated Content 2017
66 TOPCAPI Thoroughly Optimised Production Chassis for Advanced Pharmaceutical Ingredients 2017
67 TILC Targeting Innate Lymphoid Cells 2017
68 ALS-Networks Defining functional networks of genetic causes for ALS and related neurodegenerative disorders 2017
69 NGECA REGULATION OF NEURONAL GENE EXPRESSION THROUGH CHROMOSOME ARCHITECTURE 2016
70 GasPlaNt Gas sensing in plants:Oxygen- and nitric oxide-regulated chromatin modification via a targeted protein degradation mechanism 2017
71 SYSCID A Systems medicine approach to chronic inflammatory disease 2017
72 SCUBA CANCERS Finding the genetic causes of contagious metastases under the sea 2017
73 Videona Videona: The first Video Social Network for journalist and prosumers allowing them to optimize the generation of quality audio-visual content through mobile phones. 2017
74 3D_Tryps The role of three-dimensional genome architecture in antigenic variation 2017
75 LentiFactory MAGIC (MAnufacturing of Gene delivery tools for Industrial and Clinical applications) 2017
76 CARBOFLU Chemoenzymatic synthesis of complex glycans to decipher the interactions between them and Influenza A virus 2017
77 GlycoModels 3D glyco-engineered models to address the role of glycosylation in gastric cancer clinical management 2017
78 CRISP-4-CROPS CRISPR/Cas9 technology implementation for improved resistance to Abiotic Stress in cereals 2017
79 RhoSNATCH Dissecting Rho GTPase signalling networks through acute perturbation techniques 2017
80 CRISTONE Targeting CRISPR-based HDAC inhibitors to histones: a new tool for assessing mechanisms of class I HDAC inhibitors and developing chemical probes. 2017
81 Repro_organoid Direct reprogramming of human astrocytes into functional neurons in cerebral organoids derived from genome edited hiPSCs 2017
82 rDNAevol Population genomics and experimental evolution of ribosomal RNA gene variants in Arabidopsis thaliana 2017
83 EPOFFSPRING Epigenetic mechanisms underlying the influence of paternal drug experience on offspring behavior 2017
84 GRADIENTSENSING Cellular navigation along spatial gradients 2017
85 REACT Uncovering the role of cis genetic elements in antigenic variation of Plasmodium falciparum using the CRISPR-Cas9 genome editing technology 2018
86 PREMETAZOAEPIGENOME The role of genome regulation in the origin of animals 2017
87 GREEN-SPECIALISTS Specialised plant cell types via developmentally-controlled gene knockouts: a key step towards fully customised plants 2018
88 InPhoTime Insect Photoperiodic Timer 2017
89 MiRCHOL Mechanistic and therapeutic implications of microRNA deregulation for drug resistance in bile duct cancer 2017
90 MetEpiClock Circadian Control of Histone Methylation Dynamics through the Fine-tuning of Methionine Metabolic Flux 2017
91 GASAC Gender Aspects of Screen Adaptations of the British Nineteenth-Century Female Literary Canon 2017
92 ADAPTED Alzheimers Disease Apolipoprotein Pathology for Treatment Elucidation and Development - Sofia ref.: 115975 2016
93 PROXNET Modelling Complex Networks Through Graph Editing Problems 2018
94 METCLL Discovery and validation of ‘epidrivers’ of cancer evolution and resistance to therapy 2018
95 Pharynx2016 Evolution and development of pharyngeal pouches and pre-oral gut in basal fishes 2017
96 THAT IS HUNT Triggering Haematological Adoptive T-cell Immunotherapy Strategies by HUnting Novel T-cellreceptors 2018
97 BCRdangerCOMPETITION The role of danger signal and cellular competition in the elimination of B cells lacking the B cell receptor. 2017
98 HOST-SELECT Functional Analysis of Host Genetic Variants: Biomarker Selection Towards Improving Female Subfertility Diagnosis and Treatment 2017
99 IAV-m6A Elucidating the role of m6A RNA methylation on the replication and pathogenesis of influenza A virus. 2017
100 ZNEOPSIN_II The role of novel opsins in non-visual light detection in the zebrafish brain 2018
101 EpiRetention Mechanisms of selective transmission of epigenetic marks through the male germ line 2017
102 EPICODE Programmable Readers, Writers, and Erasers of the Epigenetic Cytosine Code 2017
103 EvoCellFate Evolution of cell fate decision during development 2017
104 GenEdiDS Rescuing Cognitive Deficits in Neurodevelopmental Disorders by Gene Editing in Brain Development: the Case of Down Syndrome 2017
105 SystGeneEdit Dissecting quantitative traits and their underlying genetic interactions via systematic genome editing 2017
106 BLASTOFF Retooling plant immunity for resistance to blast fungi 2017
107 HEPASPHER Mimicking liver disease and regeneration in vitro for drug development and liver transplantation 2017
108 GENSURGE Designer recombinases for efficient and safe genome surgery 2018
109 IMGENE Improving Genome Editing Efficiency (IMGENE) 2017
110 OpenPhilology Open Philology: The Composition of Buddhist Scriptures 2018
111 DeAge Deconstructing Ageing: from molecular mechanisms to intervention strategies 2017
112 PAINTBOX Pancreatic islet dysfunction and type 2 diabetes – beyond the genome 2017
113 PD UpReg Gene knock-up via 3’UTR targeting to treat Parkinson’s disease 2017
114 INCOVID Inpainting-based Compression of Visual Data 2017
115 LUPUSCARE PRECISION CARE IN SYSTEMIC AUTOIMMUNITY: AN INTEGRATED MULTI-TISSUE/LEVEL APPROACH FOR SYSTEMIC LUPUS ERYTHEMATOSUS (SLE) 2017
116 ARMOR-T Armoring multifunctional T cells for cancer therapy 2018
117 deFIBER Dissecting the cellular and molecular dynamics of bone marrow fibrosis for improved diagnostics and treatment 2018
118 CellKarma Dissecting the regulatory logic of cell fate reprogramming through integrative and single cell genomics 2018
119 CRISS CRISPR Gene Correction for Severe Combined Immunodeficiency Caused by Mutations in Recombination-activating gene 1 and 2 (RAG1 and RAG2) 2017
120 ELONGAN Gene editing and in vitro approaches to understand conceptus elongation in ungulates 2017
121 ORI NUMBER Unravelling the effect of origin number on the success of genome replication 2017
122 DIAMONDCOR A molecular approach to treat diabetes mellitus onset dependent coronaropathy 2018
123 FotoInMotion Repurposing and enriching images for immersive storytelling through smart digital tools 2018
124 REBUILDCNS Redirecting glial progenitor fate to rebuild the injured Brain 2018
125 GlycoSkin Dissection of Glycan Function by Engineered Tissue Models 2018
126 POLYADAPT Molecular-genetic mechanisms of extreme adaptation in a polyphagous agricultural pest 2018
127 SUPERMIN Correlative Super Resolution Imaging of the Collagen Mineralization Process 2018
128 iPS-ChOp-AF Combining induced pluripotent stem cells, tissue engineering, optogenetic and chemogenetic concepts for the study and treatment of atrial fibrillation 2018
129 Alpha-Synuclein Blocking the prion-like disease propagation in Parkinson’s disease and related disorders – model development and identification of cell-autonomous and cell non-autonomous factors. 2019
130 MeloCRISP Implementation of CRISPR/Cas9 technology in melon to edit fruit ripening and CMV resistant genes 2018
131 ROCKSOFT Rho GTPase cross-talk with syndecan-4 regulates pro-fibrotic mechanotransduction in the heart 2019
132 INTERGLU Dissecting mGlu5 receptor internalization pathways using genetic and pharmacological tools 2018
133 CRISPR-GQ Identifying the Capabilities and Limitations of CRISPR in Targeting G-quadruplex Forming Sequences: From Target Recognition to Gene Expression Regulation 2018
134 DEFPOLL Origins of trait diversity in flowering plants: understanding interactions between plant defence and pollination using molecular, phenotypic and ecological studies of natural selection 2018
135 ANTILEAK Development of antagonists of vascular leakage 2018
136 Sialoglycan Array Generation of a Cell-Based Sialoglycan Array to Decipher Biological Interactions and Functions of the Human Sialome 2018
137 Za-AV Determination of physiologically relevant RNA substrate(s) and design of small-molecule inhibitors for Zα domains as potential intervention strategies for viral infections and autoimmunity 2018
138 TOMATO EXODERMIS Development and drought responses of tomato exodermis 2018
139 GSAS Genomic Strategies Against STB disease of wheat 2018
140 TOLKEDA Modulating brain structural plasticity versus neurodegeneration via a novel mechanism involving neurotrophins and dopamine, Tolls and Kek truncated-Trk-like receptors in Drosophila. 2018
141 rDNAstress Novel insights into DNA damage and stress responses in the nucleolus: Mechanisms and relevance for genomic (in)stability and cancer 2019
142 PHOTO-FLUOR Enantioselective Carbon-Fluorine Bond Formation: A Molecular Editing Approach toward Drug Discovery 2018
143 PathAutoBIO Uncovering the pathway of DNA-induced autophagy and its biological functions in viral central nervous system infection 2018
144 transLEISHion A targeted knockout screen for identification of Leishmania membrane transporters required for infection of macrophages 2018
145 ItohRibo Structural study on mitochondrial ribosome assembly in human cells 2018
146 MiniBRAIN Investigating the pathogenic mechanisms underlying TUBB2B-related brain malformations using induced pluripotent stem cells and cerebral organoids. 2019
147 PathEVome Do Pathogen Extracellular Vesicles Deliver Crop Disease? 2018
148 EPICut Molecular mechanisms, evolutionary impacts and applications of prokaryotic epigenetic-targeted immune systems 2018
149 HELPHERGEN THE GENETIC BASIS OF MATING BEHAVIOR: PHEROMONE COMMUNICATION IN NOCTUID MOTHS 2018
150 EditMHC How MHC-I editing complexes shape the hierarchical immune response 2019
151 DISCOVER Death receptor signalling in tumour immune editing 2018
152 ZYMVOLVER Launching A Unified Cloud-Based Platform for Next Generation Protein Editing 2018
153 iFermenter iFERMENTER - CONVERSION OF FORESTRY SUGAR RESIDUAL STREAMS TO ANTIMICROBIAL PROTEINS BY INTELLIGENT FERMENTATION 2018
154 V.A. Cure A multidisciplinary approach towards sustainable improvement in rare diseases care uniting Europe's top class vascular research to find new treatment strategies for vascular anomalies 2019
155 BloodVariome Genetic variation exposes regulators of blood cell formation in vivo in humans 2018
156 EVOCLOCK From Evolution to Clockworks:Unravelling the molecular basis of circalunar clocks 2019
157 RiboLife Resurrecting LUCA - Engineering of RNA-encoded Cellular Life Using Dual Evolution and Intergenomic Transplantation 2019
158 RiboInflam Assessing the role of ribosomes and mRNA translation in shaping the inflammatory response 2019
159 StarT European Training Network to Diagnose, Understand and Treat Stargardt Disease, a Frequent Inherited Blinding Disorder 2018
160 EvolutioNeuroCircuit Cellular and genetic bases of neural circuits evolution 2019
161 REMIND Targeting pathological synaptic pruning by microglia in neurodegeneration 2019
162 OZeye Developing Computer Vision and Artificial Intelligence for best-quality and cost-effective live sports production and distribution 2018
163 UPGRADE Unlocking Precision Gene Therapy 2019
164 Multi RoboDOP Multi-camera autonomous robotic cameramen at the fingertips of all live video productions 2018
165 CRISPRsition Developing CRISPR adaptation platforms for basic and applied research 2019
166 MIGHTY_RNA Repurposing small RNA from ciliates for genome editing: single-molecule study 2019
167 INSPIRE System-wide discovery and analysis of inositol pyrophosphate signaling networks in plants 2019
168 EpiTune Epigenetic fine-tuning of T cells for improved adoptive cell therapy 2019
169 EPICROP Dissecting epistasis for enhanced crop productivity 2019
170 Epi4MS Targeting the epigenome: towards a better understanding of disease pathogenesis and novel therapeutic strategies in Multiple Sclerosis 2019
171 iHEAR Gene therapy of inherited and acquired hearing loss 2019
172 ImmunoStem Dissecting and Overcoming Innate Immune Barriers for Therapeutically Efficient Hematopoietic Stem Cell Gene Engineering 2019
173 CRISPR2.0 Microbial genome defence pathways: from molecular mechanisms to next-generation molecular tools 2019
174 NeuroDeRisk Neurotoxicity De-Risking in Preclinical Drug Discovery 2019
175 mitoUPR Cellular modulation by the mitochondrial unfolded protein response 2019
176 CRC-MTOs Colorectal Cancer Mouse Tumor Organoids as Pre-clinical Models for Therapeutical Testing 2018
177 R-FunSel In vivo functional screening via CRISPR-Cas9 to systematically identify cardiomyocyte receptors as targets for the innovative therapies for myocardial infarction and heart failure 2019
178 Centromere Stability Mechanisms that maintain centromere DNA repeats stability in human cells. 2020
179 FrATGaria Identification of the role of autophagy during fruit ripening and stress resistance in Strawberry: Autophagy manipulation as a way to improve Strawberry fitness 2019
180 POPMET Large-scale identification of secondary metabolites, metabolic pathways and their genes in the model tree poplar 2019
181 MsgRNA Modification of single guide (sg) RNA in CRISPR-Cas9 gene editing Tool 2019
182 SOS-CROPS Solving the tangled ontogenesis of the stem for sustainable crops 2019
183 Exh-Res-CART Exhaustion-resistant CAR-T cells for the treatment of solid tumours 2019
184 TFZN Understanding the mechanisms that govern organ morphostasis and repair 2019
185 InvADeRS Investigating the Activity of transposon Derived Regulatory Sequences in the placenta 2019
186 CRISPR-KissCas9 Challenging the KNDy Hypothesis Using CRISPR-Cas9 Genome Editing: Evaluation of the Role of Neurokinin B and Dynorphin in Kiss1 neurons in the Control of Fertility 2020
187 iMIND iPS-derived MIcroglia and Neuroinflammation in Dementia 2020
188 DADA2GT Development of gene therapy and genome editing strategies to treat adenosine deaminase 2 deficiency 2019
189 GenDels Development of a new CRISPR-Cas3-based tool for large genomic deletions 2019
190 MalusEdit Malus genome editing via CRISPR/Cas9 to develop sustainable pest free apples 2019
191 BREEDIT A NOVEL BREEDING STRATEGY USING MULTIPLEX GENOME EDITING IN MAIZE 2019
192 ReproXimera Modelling in vivo lineage reprogramming of human astrocytes into induced neurons in the adult mouse brain 2020
193 Cyanide Evolution EVOLUTION OF CYANIDE METABOLIMS IN APOSEMATIC BUTTERFLIES: from gene characterization to community ecology 2020
194 SUPERTEFF A new paradigm in boosting orphan crops to super grains: Linking metabolomics and gene editing to improve Teff for global food security and sustainable agriculture 2020
195 INNERVATE Investigating the functional impact of neurodegeneration-causing rare variants in the teleost model zebrafish 2020
196 iLCA Intelligent Live Cell Analysis [iLCA] to transform disease management through faster, and more regulatory robust, discovery, manufacture and monitoring of biologic drugs & cell therapies 2019
197 DNA-DOCK Precision Docking of Very Large DNA Cargos in Mammalian Genomes 2019
198 Breakborder Breaking borders, Functional genetic screens of structural regulatory DNA elements 2019
199 INO3D Mechanism of ATP Dependent Chromatin Modelling and Editing by INO80 Remodellers 2019
200 Genetic Vaccine Study the therapeutic and preventive potential of targeting oncogenic mutations with CRISPR-Cas9 technology 2019
201 INTERGLP1 Dissecting GLP-1 receptor internalization pathways using genetic and pharmacological tools 2020
202 QuinADAR1 Protection from malaria in the Fulani ethnic group of West Africa involves reduced levels of A-to-I RNA editing by ADAR1 2019
203 ARCH AGE-RELATED CHANGES IN HEMATOPOIESIS 2019
204 ARGO The Quest of the Argonautes - from Myth to Reality 2019
205 TRYPTISSUE Characterising Trypanosoma tissue tropism: new perspectives for variant surface glycoproteins 2019
206 I-GENE In-vivo Gene Editing by NanotransducErs 2019
207 ATCO2 Automatic collection and processing of voice data from air-traffic communications 2019
208 CellularBiographies Global views of cell type specification and differentiation 2020
209 EmbryoMethFunc Cell-Type Specific DNA Methylation Changes During Mammalian Development: Beyond Mapping 2019
210 DyNAmecs Early embryonic events, life-long consequences: DNA methylation dynamics in mammalian development 2020
211 OCTOBER Control of cell identity in pluripotent and germline cells by OCT4 orchestration of chromatin binding and enhancer regulation 2019
212 Bac2MUC Bacteria-mucin interactions – Shaping intestinal epithelial responses in health and disease 2020
213 PARPinhibit A systems biology approach to tackle PARP-inhibitors resistance and identify novel therapeutic targets to overcome it 2020
214 TO_AITION A high-dimensional approach for unwinding immune-metabolic causes of cardiovascular disease-depression multimorbidities 2020
215 DDREAMM Dna Damage REsponse: Actionabilities, Maps and Mechanisms 2020
216 CARBYNE New carbon reactivity rules for molecular editing 2020
217 ZENITH ZEbrafish Neuroscience Interdisciplinary Training Hub 2019
218 NATURE-ETN Nucleic Acids for Future Gene Editing, Immunotherapy and Epigenetic Sequence Modification 2020
219 HumanPlacenta Human Placental Development and the Uterine Microenvironment 2020
220 TAXi-ch Determination of transcription factor cooperativity driving expression from the inactive X chromosome 2020
221 DIVISION BELL The role of TETRASPANINS in plant cell division orientation 2021
222 UCUPA Unraveling the Molecular Changes that Drive the Repression of the Unfolded Protein Response with Ageing 2020
223 RE-GENESis GENome Editing and delivery Strategies for REcoding the mammalian genome 2020
224 dcPolyWheat Dominant cis-regulatory variation to improve quantitative traits in polyploid wheat 2020
225 SPHERES Lipid droplet hypertrophy : the link between adipocyte dysfunction and cardiometabolic diseases 2020
226 LyrA Lyric Authority: Editing and Rewriting Dante’s Lyric Poetry (14th – 16th c.) 2020
227 HiPhy High Phytosterol variants towards improved feedstocks and biofortification of crops 2020