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FLUORODRUGS

Smart Theranostic Agents for the Tumour Microenvironment

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

FLUORODRUGS project word cloud

Explore the words cloud of the FLUORODRUGS project. It provides you a very rough idea of what is the project "FLUORODRUGS" about.

models toxic ccl2 confirm sensitive theranostic chemical critical notably training biomarkers validate selectively cells initial imaging chemokine derivatization drug immune vitro visualisation treatment strategy tools visualise validation drugs ablate probes multidisciplinary selectivity career vivo macrophage microenvironment metastasis cancer yield minimise cytotoxic linkers subpopulations involve combining activation ligands biology mouse diagnosis cell limitations time conventional synthesis pharmacology fluorophores chemistry smart resistance cleavable run marrow render therapies agents progression ccr2 performed therapy profiling specificity macrophages spectroscopy bone generation medicinal tumour interdisciplinary monitor discover biological encompassing fluorodrugs conjugates prepare

Project "FLUORODRUGS" data sheet

The following table provides information about the project.

Coordinator	THE UNIVERSITY OF EDINBURGH Organization address address: OLD COLLEGE, SOUTH BRIDGE city: EDINBURGH postcode: EH8 9YL website: www.ed.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Project website	http://www.dynafluors.co.uk
Total cost	195˙454 €
EC max contribution	195˙454 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2015
Funding Scheme	MSCA-IF-EF-ST
Starting year	2017
Duration (year-month-day)	from 2017-01-01 to 2018-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	THE UNIVERSITY OF EDINBURGH THE UNIVERSITY OF EDINBURGH Organization address address: OLD COLLEGE, SOUTH BRIDGE city: EDINBURGH postcode: EH8 9YL website: www.ed.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (EDINBURGH)	coordinator	195˙454.00

Map

Project objective

FLUORODRUGS is a highly interdisciplinary project encompassing the design, synthesis and biological validation of novel smart chemical agents for highly sensitive diagnosis and specific treatment of cancer. I will prepare novel drug-fluorophores conjugates by combining macrophage-specific fluorophores with cytotoxic drugs using smart cleavable linkers. The activation of these smart agents in the tumour microenvironment will allow to not only to visualise in real-time but also to selectively ablate tumour-associated macrophages, which are essential for cancer progression. Further derivatization of the agents with specific ligands (i.e. chemokine CCL2) will yield probes for specific subpopulations of macrophages (i.e. CCR2 macrophages) that are critical in tumour metastasis. This strategy will minimise two of the major limitations of conventional cancer therapies: 1) drug resistance from cancer cells, and 2) toxic side effects derived from low cell specificity. Notably, the visualisation of immune cells in the tumour microenvironment will allow to monitor cancer progression in real-time and to run profiling studies to discover new biomarkers for cancer therapy. Initial in vitro studies to confirm the activity and selectivity of FLUORODRUGS will be performed in bone marrow-derived macrophages. Further, relevant mouse cancer models will be used to validate the theranostic agents in vivo. FLUORODRUGS will involve multidisciplinary training in biology, spectroscopy, pharmacology and imaging, and will render a unique generation of smart chemical tools to enhance diagnosis and treatment of cancer. This project will open a whole range of opportunities for my future career development in cancer biology and medicinal chemistry.

Publications

List of publications.
year	authors and title	journal	last update
2018	Richard J. Mellanby, Jamie I. Scott, Iris Mair, Antonio Fernandez, Louise Saul, Jochen Arlt, Monica Moral, Marc Vendrell Tricarbocyanine N -triazoles: the scaffold-of-choice for long-term near-infrared imaging of immune cells in vivo published pages: 7261-7270, ISSN: 2041-6520, DOI: 10.1039/c8sc00900g	Chemical Science 9/36	2019-07-30
2017	Antonio Fernandez, Matthieu Vermeren, Duncan Humphries, Ramon Subiros-Funosas, Nicole Barth, Lara Campana, Alison MacKinnon, Yi Feng, Marc Vendrell Chemical Modulation of in Vivo Macrophage Function with Subpopulation-Specific Fluorescent Prodrug Conjugates published pages: 995-1005, ISSN: 2374-7943, DOI: 10.1021/acscentsci.7b00262	ACS Central Science 3/9	2019-07-30
2018	Antonio Fernandez, Marc Vendrell Fluorophoreâ€“Drug Conjugates To Unravel the Mechanisms of Action of Therapeutic Assets published pages: 175-176, ISSN: 0006-2960, DOI: 10.1021/acs.biochem.7b00889	Biochemistry 57/2	2019-07-30
2019	Sam Benson, Antonio Fernandez, Nicole D Barth, Fabio de Moliner, Mathew H Horrocks, Simon Herrington, Jose Luis Abad, Antonio Delgado, Lisa Kelly, Zi Chang, Yi Feng, Miyako Nishiura, Yuichiro Hori, Kazuya Kikuchi, Marc Vendrell SCOTfluors: Small, Conjugatable, Orthogonal and Tunable Fluorophores for in vivo Imaging of Cell Metabolism published pages: , ISSN: 1433-7851, DOI: 10.1002/anie.201900465	Angewandte Chemie	2019-07-30

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The information about "FLUORODRUGS" are provided by the European Opendata Portal: CORDIS opendata.