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Born-Immune SIGNED

Shaping of the Human Immune System by Primal Environmental Exposures In the Newborn Child

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

Born-Immune project word cloud

Explore the words cloud of the Born-Immune project. It provides you a very rough idea of what is the project "Born-Immune" about.

2014 microbiota assay 200 visits al vaccines serum phenotypes cells environmental et immune birth recording trajectory risk immunological health microliters children microbiome blood monitor mass sources mechanisms newborn influence profiles regular environment variation heritable frequencies individual severe exposures shape longitudinally proteins fraction hope followed mediated influential infections twins potentially forming human date populations accurately vary influences questionnaires pnas transformational poorly imprinting tools data 2015 infection first healthy 1000 disease predict cell explains monitoring genetic found months cytometry follow sequencing minor days regulatory understand functional adaptive gut life competence simultaneously brodin unable

Project "Born-Immune" data sheet

The following table provides information about the project.

Coordinator	KAROLINSKA INSTITUTET Organization address address: Nobels Vag 5 city: STOCKHOLM postcode: 17177 website: www.ki.se contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Sweden [SE]
Project website	https://brodinlab.com/newborns/
Total cost	1˙422˙338 €
EC max contribution	1˙422˙338 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2015-STG
Funding Scheme	ERC-STG
Starting year	2016
Duration (year-month-day)	from 2016-07-01 to 2021-06-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	KAROLINSKA INSTITUTET KAROLINSKA INSTITUTET Organization address address: Nobels Vag 5 city: STOCKHOLM postcode: 17177 website: www.ki.se contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (STOCKHOLM)	coordinator	1˙422˙338.00

Map

Project objective

Immune systems are highly variable, but the sources of this variation are poorly understood. Genetic variation only explains a minor fraction of this, and we are unable to accurately predict the risk of immune mediated disease or severe infection in any given individual. I recently found that immune cells and proteins in healthy twins vary because of non-heritable influences (infections, vaccines, microbiota etc.), with only minor influences from heritable factors (Brodin, et al, Cell 2015). When and how such environmental influences shape our immune system is now important to understand. Birth represents the most transformational change in environment during the life of any individual. I propose, that environmental influences at birth, and during the first months of life could be particularly influential by imprinting on the regulatory mechanisms forming in the developing immune system. Adaptive changes in immune cell frequencies and functional states induced by early-life exposures could determine both the immune competence of the newborn, but potentially also its long-term trajectory towards immunological health or disease. Here, I propose a study of 1000 newborn children, followed longitudinally during their first 1000 days of life. By monitoring immune profiles and recording many environmental influences, we hope to understand how early life exposures can influence human immune system development. We have established a new assay based on Mass Cytometry and necessary data analysis tools (Brodin, et al, PNAS 2014), to simultaneously monitor the frequencies, phenotypes and functional states of more than 200 blood immune cell populations from only 100 microliters of blood. By monitoring environmental influences at regular follow-up visits, by questionnaires, serum measurements of infection, and gut microbiome sequencing, we aim to provide the most comprehensive analysis to date of immune system development in newborn children.

Publications

List of publications.
year	authors and title	journal	last update
2018	Axel Olin, Ewa Henckel, Yang Chen, Tadepally Lakshmikanth, Christian Pou, Jaromir Mikes, Anna Gustafsson, Anna Karin Bernhardsson, Cheng Zhang, Kajsa Bohlin, Petter Brodin Stereotypic Immune System Development in Newborn Children published pages: 1277-1292.e14, ISSN: 0092-8674, DOI: 10.1016/j.cell.2018.06.045	Cell 174/5	2019-04-18

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