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FunCapSys SIGNED

Functional Systems of Capsules

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

FunCapSys project word cloud

Explore the words cloud of the FunCapSys project. It provides you a very rough idea of what is the project "FunCapSys" about.

elucidate biology engineering interactions guests chemical subsystems reversibly emerge place impeding organism phases abiological foundations hosts occurs transduction living capsules life guest structurally consisting deciphering dense transformed biomolecules signals functional creation myriad simplest changing catalysts ways connections ultimately binding accelerating catalysed cycles interact transformations signal irreversibly designing disfavour light released loops tools feedback functions predictable networks pumped

Project "FunCapSys" data sheet

The following table provides information about the project.

Coordinator	THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE Organization address address: TRINITY LANE THE OLD SCHOOLS city: CAMBRIDGE postcode: CB2 1TN website: www.cam.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Total cost	2˙478˙236 €
EC max contribution	2˙478˙236 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2015-AdG
Funding Scheme	ERC-ADG
Starting year	2017
Duration (year-month-day)	from 2017-01-01 to 2021-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE Organization address address: TRINITY LANE THE OLD SCHOOLS city: CAMBRIDGE postcode: CB2 1TN website: www.cam.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (CAMBRIDGE)	coordinator	2˙478˙236.00

Map

Project objective

The simplest living organism is composed of myriad chemical subsystems, each consisting of structurally complex biomolecules that interact in many ways; the properties of life emerge from these dense connections. Understanding how these interactions take place will help elucidate the foundations of biology, as well as enabling the design and creation of new chemical networks with targeted functions. Deciphering and designing chemical systems requires new tools to be developed, however. In this research programme, we will develop new means for engineering functional chemical systems based upon the use of guest-binding capsules. These hosts will respond to many different signals in predictable ways. Their responses will enable their guests to be transformed in new ways or pumped between phases using light. Chemical signals will enable hosts to be transformed reversibly or irreversibly, changing their guest binding properties so as to favour some guests and disfavour others, and catalysts will be released or taken up, accelerating or impeding catalysed transformations. Ultimately we will design systems where signal transduction occurs in complex cycles and feedback loops, allowing complex behaviour to emerge from abiological systems.

Publications

List of publications.
year	authors and title	journal	last update
2019	Dawei Zhang, Tanya K. Ronson, SongÃ¼l GÃ¼ryel, John D. Thoburn, David J. Wales, Jonathan R. Nitschke Temperature Controls Guest Uptake and Release from Zn 4 L 4 Tetrahedra published pages: 14534-14538, ISSN: 0002-7863, DOI: 10.1021/jacs.9b07307	Journal of the American Chemical Society 141/37	2020-01-30
2019	Dawei Zhang, Tanya K. Ronson, Roy Lavendomme, Jonathan R. Nitschke Selective Separation of Polyaromatic Hydrocarbons by Phase Transfer of Coordination Cages published pages: 18949-18953, ISSN: 0002-7863, DOI: 10.1021/jacs.9b10741	Journal of the American Chemical Society 141/48	2020-01-30
2020	Zhenpin Lu, Tanya K. Ronson, Jonathan R. Nitschke Reversible reduction drives anion ejection and C 60 binding within an FeII4L 6 cage published pages: , ISSN: 2041-6520, DOI: 10.1039/c9sc05728e	Chemical Science	2020-01-30
2019	Masahiro Yamashina, Yuya Tanaka, Roy Lavendomme, Tanya K. Ronson, Michael Pittelkow, Jonathan R. Nitschke An antiaromatic-walled nanospace published pages: 511-515, ISSN: 0028-0836, DOI: 10.1038/s41586-019-1661-x	Nature 574/7779	2020-01-30
2019	Charlie T. McTernan, Tanya K. Ronson, Jonathan R. Nitschke Post-assembly Modification of Phosphine Cages Controls Hostâ€“Guest Behavior published pages: 6837-6842, ISSN: 0002-7863, DOI: 10.1021/jacs.9b02604	Journal of the American Chemical Society 141/17	2020-01-22
2019	John P. Carpenter, Charlie T. McTernan, Tanya K. Ronson, Jonathan R. Nitschke Anion Pairs Template a Trigonal Prism with Disilver Vertices published pages: 11409-11413, ISSN: 0002-7863, DOI: 10.1021/jacs.9b05432	Journal of the American Chemical Society 141/29	2020-01-22
2018	Anna J. McConnell, Cally J. E. Haynes, Angela B. Grommet, Catherine M. Aitchison, Julia Guilleme, Sigitas Mikutis, Jonathan R. Nitschke Orthogonal Stimuli Trigger Self-Assembly and Phase Transfer of Fe II 4 L 4 Cages and Cargoes published pages: 16952-16956, ISSN: 0002-7863, DOI: 10.1021/jacs.8b11324	Journal of the American Chemical Society 140/49	2020-01-22
2018	Felix J. Rizzuto, Patrick PrÃ¶hm, Alex J. Plajer, Jake L. Greenfield, Jonathan R. Nitschke Hydrogen-Bond-Assisted Symmetry Breaking in a Network of Chiral Metalâ€“Organic Assemblies published pages: 1707-1715, ISSN: 0002-7863, DOI: 10.1021/jacs.8b12323	Journal of the American Chemical Society 141/4	2020-01-22
2019	Roy Lavendomme, Tanya K. Ronson, Jonathan R. Nitschke Metal and Organic Templates Together Control the Size of Covalent Macrocycles and Cages published pages: 12147-12158, ISSN: 0002-7863, DOI: 10.1021/jacs.9b06182	Journal of the American Chemical Society 141/30	2020-01-22
2019	Anneli Kruve, Kenji Caprice, Roy Lavendomme, Jan M. WollschlÃ¤ger, Stefan Schoder, Hendrik V. SchrÃ¶der, Jonathan R. Nitschke, Fabien B. L. Cougnon, Christoph A. Schalley Ion-Mobility Mass Spectrometry for the Rapid Determination of the Topology of Interlocked and Knotted Molecules published pages: 11324-11328, ISSN: 1433-7851, DOI: 10.1002/anie.201904541	Angewandte Chemie International Edition 58/33	2020-01-22
2019	Felix J. Rizzuto, John P. Carpenter, Jonathan R. Nitschke Multisite Binding of Drugs and Natural Products in an Entropically Favorable, Heteroleptic Receptor published pages: 9087-9095, ISSN: 0002-7863, DOI: 10.1021/jacs.9b03776	Journal of the American Chemical Society 141/22	2020-01-22
2018	Angela B. Grommet, Jack B. Hoffman, Edmundo G. PercÃ¡stegui, JesÃºs Mosquera, Duncan J. Howe, Jeanne L. Bolliger, Jonathan R. Nitschke Anion Exchange Drives Reversible Phase Transfer of Coordination Cages and Their Cargoes published pages: 14770-14776, ISSN: 0002-7863, DOI: 10.1021/jacs.8b07900	Journal of the American Chemical Society 140/44	2020-01-22
2019	Alex J. Plajer, Edmundo G. PercÃ¡stegui, Marco Santella, Felix J. Rizzuto, Quan Gan, Bo W. Laursen, Jonathan R. Nitschke Fluorometric Recognition of Nucleotides within a Water-Soluble Tetrahedral Capsule published pages: 4200-4204, ISSN: 1433-7851, DOI: 10.1002/anie.201814149	Angewandte Chemie International Edition 58/13	2020-01-22
2019	Nozomi Mihara, Tanya K. Ronson, Jonathan R. Nitschke Different Modes of Anion Response Cause Circulatory Phase Transfer of a Coordination Cage with Controlled Directionality published pages: , ISSN: 1433-7851, DOI: 10.1002/anie.201906644	Angewandte Chemie International Edition	2020-01-22
2019	Felix J. Rizzuto, Larissa K. S. von Krbek, Jonathan R. Nitschke Strategies for binding multiple guests in metalâ€“organic cages published pages: 204-222, ISSN: 2397-3358, DOI: 10.1038/s41570-019-0085-3	Nature Reviews Chemistry 3/4	2020-01-22
2019	Dawei Zhang, Tanya K. Ronson, Jake L. Greenfield, Thierry Brotin, Patrick Berthault, Estelle LÃ©once, Jun-Long Zhu, Lin Xu, Jonathan R. Nitschke Enantiopure [Cs + /XeâŠ‚Cryptophane]âŠ‚Fe II 4 L 4 Hierarchical Superstructures published pages: , ISSN: 0002-7863, DOI: 10.1021/jacs.9b02866	Journal of the American Chemical Society	2020-01-22
2019	Zhenpin Lu, Roy Lavendomme, Olaf Burghaus, Jonathan R. Nitschke A Zn 4 L 6 Capsule with Enhanced Catalytic Câˆ’C Bond Formation Activity upon C 60 Binding published pages: 9073-9077, ISSN: 1433-7851, DOI: 10.1002/anie.201903286	Angewandte Chemie International Edition 58/27	2020-01-22
2019	Edmundo G. PercÃ¡stegui, JesÃºs Mosquera, Tanya K. Ronson, Alex J. Plajer, Marion Kieffer, Jonathan R. Nitschke Waterproof architectures through subcomponent self-assembly published pages: 2006-2018, ISSN: 2041-6520, DOI: 10.1039/c8sc05085f	Chemical Science 10/7	2020-01-22
2018	Dawei Zhang, Tanya K. Ronson, Jonathan R. Nitschke Functional Capsules via Subcomponent Self-Assembly published pages: , ISSN: 0001-4842, DOI: 10.1021/acs.accounts.8b00303	Accounts of Chemical Research	2020-01-22
2018	Felix J. Rizzuto, William J. Ramsay, Jonathan R. Nitschke Otherwise unstable structures self-assemble in the cavities of cuboctahedral coordination cages published pages: , ISSN: 0002-7863, DOI: 10.1021/jacs.8b07494	Journal of the American Chemical Society	2020-01-22
2018	Jake L. Greenfield, Emrys W. Evans, Daniele Di Nuzzo, Marco Di Antonio, Richard H. Friend, Jonathan R. Nitschke Unraveling Mechanisms of Chiral Induction in Double-Helical Metallopolymers published pages: 10344â€“10353, ISSN: 0002-7863, DOI: 10.1021/jacs.8b06195	Journal of the American Chemical Society 140(32)	2020-01-22
2017	Anna J. McConnell, Catherine M. Aitchison, Angela B. Grommet, Jonathan R. Nitschke Subcomponent Exchange Transforms an Fe II 4 L 4 Cage from High- to Low-Spin, Switching Guest Release in a Two-Cage System published pages: 6294-6297, ISSN: 0002-7863, DOI: 10.1021/jacs.7b01478	Journal of the American Chemical Society 139/18	2020-01-22
2018	Jonathan Nitschke, Christoph A. Schalley, Ben S. Pilgrim, Derrick A. Roberts, Larissa K. S. von Krbek Multivalent Crown-ether Receptors Enable Allosteric Regulation of Anion Exchange in an Feâ‚„Lâ‚† Tetrahedron published pages: , ISSN: 1433-7851, DOI: 10.1002/anie.201808534	Angewandte Chemie International Edition	2020-01-22
2017	Edmundo G. PercÃ¡stegui, JesÃºs Mosquera, Jonathan R. Nitschke Anion Exchange Renders Hydrophobic Capsules and Cargoes Water-Soluble published pages: 9136-9140, ISSN: 1433-7851, DOI: 10.1002/anie.201705093	Angewandte Chemie International Edition 56/31	2020-01-22
2018	Derrick A. Roberts, Ben S. Pilgrim, Jonathan R. Nitschke Covalent post-assembly modification in metallosupramolecular chemistry published pages: 626-644, ISSN: 0306-0012, DOI: 10.1039/c6cs00907g	Chemical Society Reviews 47/2	2020-01-22
2018	Evan N. Keyzer, Alexandru Sava, Tanya K. Ronson, Jonathan R. Nitschke, Anna J. McConnell Post-Assembly Reactivity of N -Aryl Iminoboronates: Reversible Radical Coupling and Unusual Bâˆ’N Dynamic Covalent Chemistry published pages: 12000-12005, ISSN: 0947-6539, DOI: 10.1002/chem.201802790	Chemistry - A European Journal 24(46)	2020-01-22

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