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PFKFBLOCK SIGNED
Translating fundamental insights in endothelial metabolism: PFKFB3 drug discovery and development
Total Cost €
0EC-Contrib. €
0Partnership
0Views
0PFKFBLOCK project word cloud
Explore the words cloud of the PFKFBLOCK project. It provides you a very rough idea of what is the project "PFKFBLOCK" about.
vegf
strategy
block
angiogenic
orally
attractive
anti
causing
sufficed
transiently
glycolytic
drug
pfkfb3
angiogenesis
first
determines
inhibitor
sprouting
blocking
proof
intellectual
grant
ocular
agents
underscoring
glycolysis
pathologies
contributes
small
entirely
blockade
cells
lining
metabolism
unmet
pro
therapeutic
blood
inhibit
discovery
lowering
efficacy
cancer
time
trials
urgent
therapy
property
molecules
clinical
blocker
endothelial
insufficient
exists
validated
strategies
ecmetabolism
blinding
pathological
erc
disease
models
inflammation
restrict
resistance
toxicity
patented
systemic
ultimate
molecule
regulator
therapies
ecs
vivo
compounds
vessels
vessel
pfkfblock
glucose
metabolic
Project "PFKFBLOCK" data sheet
The following table provides information about the project.
| Coordinator |
VIB VZW
Organization address contact info |
| Coordinator Country | Belgium [BE] |
| Total cost | 150˙000 € |
| EC max contribution | 150˙000 € (100%) |
| Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
| Code Call | ERC-2015-PoC |
| Funding Scheme | ERC-POC |
| Starting year | 2016 |
| Duration (year-month-day) | from 2016-08-01 to 2018-01-31 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | VIB VZW | BE (ZWIJNAARDE - GENT) | coordinator | 150˙000.00 |
Map
Project objective
Angiogenesis, the growth of new blood vessels, contributes to major pathologies such as blinding ocular disease, inflammation and cancer. Blocking angiogenesis has therefore become a major field of research and an attractive therapeutic strategy. Current anti-angiogenic therapies focus on blockade of pro-angiogenic factors, such as VEGF. However, in cancer, insufficient efficacy, resistance and toxicity restrict the success of anti-VEGF agents. There is thus an urgent unmet need for novel anti-angiogenic strategies. In our ERC Advanced research grant (ECMetabolism), we developed an entirely novel anti-angiogenic concept and strategy, based on targeting key metabolic pathways in endothelial cells (ECs), cells lining blood vessels. More in particular, we identified - for the first time - that PFKFB3, a key glycolytic regulator, as a novel and promising target for anti-angiogenic therapy. Our findings show that glucose metabolism determines vessel sprouting and that lowering glycolysis only partially and transiently (by blocking PFKFB3) sufficed to inhibit pathological angiogenesis without causing systemic effects. In this ERC proof of concept project, PFKFBLOCK, we aim to develop lead small molecule compounds, blocking PFKFB3, and evaluate their potential to block pathological angiogenesis. Currently, no specific and orally available PFKFB3 blocker exists underscoring the value of our proposal and the necessity to develop such blocker for therapeutic applications. Through collaboration with a drug discovery unit we will identify lead molecules with novel intellectual property potential. Those lead compounds will be validated in relevant in vivo models and considered to be patented. The ultimate goal of this project is to get the best PFKFB3 inhibitor in clinical trials.
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The information about "PFKFBLOCK" are provided by the European Opendata Portal: CORDIS opendata.
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