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VGAP

The Viral Genome Associated Proteome

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

VGAP project word cloud

Explore the words cloud of the VGAP project. It provides you a very rough idea of what is the project "VGAP" about.

analyze proteins antiviral unknown viral expression cross chromatin simplex intrinsic proof protein efficient repair papillomaviruses interact precipitated applicable serve discovered mass time capture combine structure proteomics linked small interactions proteome treatment spark genomics plethora functional gene physically selectively replication vaccination biology virus genome profit vgap immunity paraformaldehyde establishment screening initially hybridization inhibitors herpes libraries cellular virology entire tool reveal herpesviruses adenoviruses modification spectrometry theory viruses hyccapp name regulation think refinement dna human molecule therapy strategies pathogens scope certain

Project "VGAP" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITATSKLINIKUM ERLANGEN Organization address address: MAXIMILIANSPLATZ 2 city: ERLANGEN postcode: 91054 website: www.uk-erlangen.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Germany [DE]
Project website	http://www.virologie.uk-erlangen.de/en/research/research-groups/research-group-of-a-ensser/vgap/
Total cost	171˙460 €
EC max contribution	171˙460 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2015
Funding Scheme	MSCA-IF-EF-RI
Starting year	2017
Duration (year-month-day)	from 2017-02-01 to 2019-07-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITATSKLINIKUM ERLANGEN UNIVERSITATSKLINIKUM ERLANGEN Organization address address: MAXIMILIANSPLATZ 2 city: ERLANGEN postcode: 91054 website: www.uk-erlangen.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (ERLANGEN)	coordinator	171˙460.00

Map

Project objective

The aim of this study is to analyze the comprehensive proteome associated with viral DNA. This systems biology approach that will combine functional proteomics and genomics has the name Viral Genome Associated Proteome (VGAP). It is based on a modification and refinement of the Hybridization Capture of Chromatin Associated Proteins for Proteomics (HyCCAPP) technology. All proteins associated with viral DNA, initially using Herpes simplex virus for proof of concept, will be cross-linked by paraformaldehyde treatment, the viral DNA will be selectively precipitated, and all proteins associated with the viral genome will be analyzed by mass spectrometry. The results will reveal all cellular and viral proteins that physically interact with the viral genome at a certain time and that are involved among others in regulation of viral genome structure, viral gene expression, DNA repair and cellular intrinsic immunity. The development of VGAP, a new method for the specific analysis of the viral genome-associated proteome will provide a new tool for the research of DNA viruses. In theory VGAP should be applicable to all DNA viruses, and we think it will be possible to analyze proteins associated with the DNA of all DNA viruses, so the entire field of virology should profit from the establishment of viral HyCCAPP. DNA viruses include important human pathogens like herpesviruses, human papillomaviruses and adenoviruses. A plethora of novel viral DNA-protein interactions will be discovered that will spark new research projects and can serve as new targets for antiviral therapy and vaccination strategies. Although beyond the scope of this proposal, so far unknown cellular proteins that are needed for efficient viral replication can be used for screening of small molecule libraries and novel small molecule inhibitors identified for antiviral therapy.

Publications

List of publications.
year	authors and title	journal	last update
2019	Florian Full, Armin Ensser Early Nuclear Events after Herpesviral Infection published pages: 1408, ISSN: 2077-0383, DOI: 10.3390/jcm8091408	Journal of Clinical Medicine 8/9	2020-01-29
2017	Florian Full, Alexander Hahn, Anna GroÃŸkopf, Armin Ensser Gammaherpesviral Tegument Proteins, PML-Nuclear Bodies and the Ubiquitin-Proteasome System published pages: 308, ISSN: 1999-4915, DOI: 10.3390/v9100308	Viruses 9/10	2020-01-29

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The information about "VGAP" are provided by the European Opendata Portal: CORDIS opendata.