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ImmProDynamics SIGNED

Dissecting the interplay between the dynamics of immune responses and pathogen proliferation in vivo

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

ImmProDynamics project word cloud

Explore the words cloud of the ImmProDynamics project. It provides you a very rough idea of what is the project "ImmProDynamics" about.

heterogenic react tissue strategies pathogens host mutants manipulate signaling niche resistance implications differentially unknown immune differential probing relationship cellular involvement insights rate cells reporter induction interaction molecular critical counteract persistence question proliferating rates link phagocyte time therapy cell versus protective interactions physiological dynamics deficient treatment antibiotic difficulties never immprodynamics efficient expand confronting microbial variety infections optogenetic proliferation infected antimicrobial first vivo proliferates vaccines apc proliferative profound inactivation pathogen mechanism distinguish

Project "ImmProDynamics" data sheet

The following table provides information about the project.

Coordinator	OTTO-VON-GUERICKE-UNIVERSITAET MAGDEBURG Organization address address: UNIVERSITAETSPLATZ 2 city: MAGDEBURG postcode: 39106 website: www.ovgu.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Germany [DE]
Project website	https://www.ovgu.de/en/Research/Research
Total cost	1˙499˙525 €
EC max contribution	1˙499˙525 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2016-STG
Funding Scheme	ERC-STG
Starting year	2017
Duration (year-month-day)	from 2017-03-01 to 2022-02-28

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	OTTO-VON-GUERICKE-UNIVERSITAET MAGDEBURG OTTO-VON-GUERICKE-UNIVERSITAET MAGDEBURG Organization address address: UNIVERSITAETSPLATZ 2 city: MAGDEBURG postcode: 39106 website: www.ovgu.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (MAGDEBURG)	coordinator	1˙499˙525.00

Map

Project objective

Pathogen proliferation has profound implications for its persistence, treatment strategies, and the induction and execution of protective immune responses. In vivo, pathogen proliferation rates are heterogenic, confronting the immune system with a variety of microbial physiological states. It is unknown if, and by what molecular mechanism, the immune response can distinguish these different states on a cellular level. Also, understanding the link between pathogen proliferation and immune cell dynamics could provide critical information on how infections can be controlled, and how to counteract pathogen persistence and antibiotic resistance. However, this question has never been addressed due to difficulties in studying the dynamics of immune cells and at the same time probing pathogen proliferation. In this project, we will make use of a novel in vivo reporter system that I have developed, in order to determine the role of the pathogen's proliferation for its interaction with the immune system. Specifically, we will (1) determine the tissue niche in which the pathogen proliferates, (2) investigate the differential dynamics of phagocyte-pathogen- and of T cell-APC-interactions related to pathogen proliferation rate, (3) manipulate the relationship between pathogen proliferation and immune cell dynamics by using proliferation-deficient mutants and optogenetic pathogen inactivation, (4) identify signaling pathways that are differentially induced in cells infected by high versus low proliferating pathogens, and test their involvement in differential immune cell dynamics related to pathogen proliferation. ImmProDynamics will for the first time provide insights into how cells of the immune system react to distinct pathogen proliferative states in vivo. This will greatly expand our knowledge of host-pathogen interactions, which will be critical for the design of efficient vaccines and antimicrobial therapy.

Publications

List of publications.
year	authors and title	journal	last update
2019	Elena A. SeiÃŸ, Anna Krone, Pauline Formaglio, Oliver Goldmann, Susanne Engelmann, Burkhart Schraven, Eva Medina, Andreas J. MÃ¼ller Longitudinal proliferation mapping in vivo reveals NADPH oxidase-mediated dampening of Staphylococcus aureus growth rates within neutrophils published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-019-42129-6	Scientific Reports 9/1	2019-09-26
2018	Sandrina Heyde, Lars Philipsen, Pauline Formaglio, Yan Fu, Iris Baars, Guido HÃ¶bbel, Corinna L. Kleinholz, Elena A. SeiÃŸ, Juliane Stettin, Patricia Gintschel, Anne Dudeck, Philippe Bousso, Burkhart Schraven, Andreas J. MÃ¼ller CD11c-expressing Ly6C+CCR2+ monocytes constitute a reservoir for efficient Leishmania proliferation and cell-to-cell transmission published pages: e1007374, ISSN: 1553-7374, DOI: 10.1371/journal.ppat.1007374	PLOS Pathogens 14/10	2019-09-26

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The information about "IMMPRODYNAMICS" are provided by the European Opendata Portal: CORDIS opendata.