#	Pagina
attuale pagina	/open-h2020/projects/207392/index.html

Opendata, web and dolomites

ChemEpigen SIGNED

The chemical understanding of biomolecular recognition in epigenetics

Total Cost €

EC-Contrib. €

Partnership

Views

ChemEpigen project word cloud

Explore the words cloud of the ChemEpigen project. It provides you a very rough idea of what is the project "ChemEpigen" about.

nucleosome molecular regulation erc unstructured epigenetic disease methyllysine roles mechanisms examine biomedical biomolecular enzymatic basis framework unravel tails water atomic experimentally intact notably human elucidation interventions play genes biochemical covalent histone found peptides sophistication form chemical physical arrays cancer structural proteins regulate underlying health histones containing posttranslational synergistic computational dna computationally assembly complete constituents unprecedented epigenetics organic regarded recognition modifications treatment ultimate thermodynamic fundamental chemistry elemental genuinely therapeutic methylarginine interactions perspective origin refers

Project "ChemEpigen" data sheet

The following table provides information about the project.

Coordinator	SYDDANSK UNIVERSITET Organization address address: CAMPUSVEJ 55 city: ODENSE M postcode: 5230 website: www.sdu.dk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Denmark [DK]
Total cost	1˙500˙000 €
EC max contribution	1˙500˙000 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2016-STG
Funding Scheme	ERC-STG
Starting year	2017
Duration (year-month-day)	from 2017-04-01 to 2022-03-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	SYDDANSK UNIVERSITET SYDDANSK UNIVERSITET Organization address address: CAMPUSVEJ 55 city: ODENSE M postcode: 5230 website: www.sdu.dk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (ODENSE M)	coordinator	1˙266˙890.00
2	STICHTING KATHOLIEKE UNIVERSITEIT STICHTING KATHOLIEKE UNIVERSITEIT Organization address address: GEERT GROOTEPLEIN NOORD 9 city: NIJMEGEN postcode: 6525 EZ website: www.radboudumc.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (NIJMEGEN)	participant	233˙110.00

Map

Project objective

The ultimate aim of this ERC project is to provide a comprehensive and complete understanding, at the atomic-level of sophistication, of genuinely important biomolecular recognition processes in epigenetics that play key roles in human health and disease. At the biochemical level, epigenetics refers to mechanisms, such as enzymatic modifications of DNA and posttranslational modifications of the associated histone proteins, that regulate the activity of human genes. The proposed work aims to address epigenetics using the physical-organic chemistry approach that enables the elucidation of the elemental processes with unprecedented molecular/atomic detail. The project will experimentally and computationally examine non-covalent interactions between three essential constituents of the epigenetic biomolecular system, namely epigenetic proteins, histones and water, at the level of short histone peptides, intact histone proteins, the nucleosome assembly and nucleosome arrays. Our programme, built on synergistic thermodynamic, structural and computational studies, aims to unravel i) the underlying chemical origin of methyllysine-containing histones in epigenetics, ii) the chemical basis for the recognition of methylarginine-containing histones in epigenetic processes, and iii) the role of unstructured histone tails in biomolecular recognition, which together form the three main structural elements found in the epigenetic framework. Results from this work will be important from both a fundamental molecular perspective as well as from the biomedical perspective, because proteins involved in epigenetic regulation processes are currently regarded as important targets for numerous therapeutic interventions, most notably for cancer treatment.

Publications

List of publications.
year	authors and title	journal	last update
2020	Abbas H. K. Al Temimi, Paul B. White, Marcus J. M. Mulders, Nicole G. A. van der Linden, Richard H. Blaauw, Anita Wegert, Floris P. J. T. Rutjes, Jasmin MecinoviÄ‡ Methylation of geometrically constrained lysine analogues by histone lysine methyltransferases published pages: 3039-3042, ISSN: 1359-7345, DOI: 10.1039/c9cc09098c	Chemical Communications 56/20	2020-03-24
2020	Abbas H. K. Al Temimi, Vu Tran, Ruben S. Teeuwen, Arthur J. Altunc, Helene I. V. Amatdjais-Groenen, Paul B. White, Danny C. Lenstra, Giordano Proietti, Yali Wang, Anita Wegert, Richard H. Blaauw, Ping Qian, Wansheng Ren, Hong Guo, Jasmin MecinoviÄ‡ Examining sterically demanding lysine analogs for histone lysine methyltransferase catalysis published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-020-60337-3	Scientific Reports 10/1	2020-03-24
2019	Abbas H. K. Al Temimi, Renate van der Wekken-de Bruijne, Giordano Proietti, Hong Guo, Ping Qian, Jasmin MecinoviÄ‡ Î³-Thialysine versus Lysine: An Insight into the Epigenetic Methylation of Histones published pages: 1798-1804, ISSN: 1043-1802, DOI: 10.1021/acs.bioconjchem.9b00313	Bioconjugate Chemistry 30/6	2020-02-19
2019	Bas J. G. E. Pieters, Jordi C. J. Hintzen, Yvonne Grobben, Abbas H. K. Al Temimi, Jos J. A. G. Kamps, Jasmin MecinoviÄ‡ Installation of Trimethyllysine Analogs on Intact Histones via Cysteine Alkylation published pages: 952-958, ISSN: 1043-1802, DOI: 10.1021/acs.bioconjchem.9b00065	Bioconjugate Chemistry 30/3	2020-02-19
2019	Abbas H. K. Al Temimi, Helene I. V. Amatdjais-Groenen, Y. Vijayendar Reddy, Richard H. Blaauw, Hong Guo, Ping Qian, Jasmin MecinoviÄ‡ The nucleophilic amino group of lysine is central for histone lysine methyltransferase catalysis published pages: 112, ISSN: 2399-3669, DOI: 10.1038/s42004-019-0210-8	Communications Chemistry 2/1	2020-02-19
2017	Roman Belle, Abbas H. K. Al Temimi, Kiran Kumar, Bas J. G. E. Pieters, Anthony Tumber, James E. Dunford, Catrine Johansson, Udo Oppermann, Tom Brown, Christopher J. Schofield, Richard J. Hopkinson, Robert S. Paton, Akane Kawamura, Jasmin MecinoviÄ‡ Investigating d -lysine stereochemistry for epigenetic methylation, demethylation and recognition published pages: 13264-13267, ISSN: 1359-7345, DOI: 10.1039/c7cc08028j	Chemical Communications 53/99	2020-02-19
2018	Abbas H. K. Al Temimi, Roman Belle, Kiran Kumar, Jordi Poater, Peter Betlem, Bas J. G. E. Pieters, Robert S. Paton, F. Matthias Bickelhaupt, Jasmin MecinoviÄ‡ Recognition of shorter and longer trimethyllysine analogues by epigenetic reader proteins published pages: 2409-2412, ISSN: 1359-7345, DOI: 10.1039/c8cc01009a	Chemical Communications 54/19	2020-02-19

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "CHEMEPIGEN" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "CHEMEPIGEN" are provided by the European Opendata Portal: CORDIS opendata.