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HIVACAR SIGNED

Evaluating a Combination of Immune-based Therapies to Achieve a Functional Cure of HIV Infection

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

HIVACAR project word cloud

Explore the words cloud of the HIVACAR project. It provides you a very rough idea of what is the project "HIVACAR" about.

quality participating view hivacar therapy proof trial patient limited improvement discontinuation rest public immune stakeholders reversing responsible engagement data neutralizing until cure antibodies actual clinical residual successfully cd4 levels hiv health vaccines thanks social population point innovation agents viral paradigm society cell life overwhelming functional communication shown maintenance benefits therapeutic ml iia conceived reservoirs threshold strategy virus count latency framework analysed therapies combine obtaining patients perfectly copies antiretroviral inception load broadly replication socio tailor psycho economic designed treatment below

Project "HIVACAR" data sheet

The following table provides information about the project.

Coordinator	CONSORCI INSTITUT D'INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER Organization address address: CALLE ROSSELLO 149 PUERTA BJS city: BARCELONA postcode: 8036 website: http://www.idibaps.org/en_index.html contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Spain [ES]
Project website	http://www.hivacar.org/
Total cost	6˙822˙299 €
EC max contribution	6˙685˙111 € (98%)
Programme	1. H2020-EU.3.1.3. (Treating and managing disease)
Code Call	H2020-SC1-2016-RTD
Funding Scheme	RIA
Starting year	2017
Duration (year-month-day)	from 2017-01-01 to 2021-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	CONSORCI INSTITUT D'INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER CONSORCI INSTITUT D'INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER Organization address address: CALLE ROSSELLO 149 PUERTA BJS city: BARCELONA postcode: 8036 website: http://www.idibaps.org/en_index.html contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (BARCELONA)	coordinator	2˙859˙183.00
2	FUNDACIO PRIVADA INSTITUT DE RECERCA DE LA SIDA-CAIXA FUNDACIO PRIVADA INSTITUT DE RECERCA DE LA SIDA-CAIXA Organization address address: CARRETERA DE CANYET city: BARCELONA postcode: 8916 website: www.irsicaixa.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (BARCELONA)	participant	714˙375.00
3	THE ROCKEFELLER UNIVERSITY NOT FOR PROFIT CORPORATION THE ROCKEFELLER UNIVERSITY NOT FOR PROFIT CORPORATION Organization address address: YORK AVENUE 1230 city: NEW YORK postcode: 10065 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	US (NEW YORK)	participant	706˙250.00
4	AARHUS UNIVERSITET AARHUS UNIVERSITET Organization address address: NORDRE RINGGADE 1 city: AARHUS C postcode: 8000 website: www.au.dk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (AARHUS C)	participant	496˙250.00
5	ECRIN EUROPEAN CLINICAL RESEARCH INFRASTRUCTURE NETWORK ECRIN EUROPEAN CLINICAL RESEARCH INFRASTRUCTURE NETWORK Organization address address: 5 RUE WATT city: PARIS postcode: 75013 website: www.ecrin.org contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	participant	309˙275.00
6	ZABALA INNOVATION CONSULTING, S.A. ZABALA INNOVATION CONSULTING, S.A. Organization address address: PASEO SANTXIKI 3 BIS city: MUTILVA ALTA NAVARRA postcode: 31192 website: www.zabala.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (MUTILVA ALTA NAVARRA)	participant	273˙125.00
7	AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS Organization address address: CALLE SERRANO 117 city: MADRID postcode: 28006 website: http://www.csic.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (MADRID)	participant	238˙063.00
8	ASSISTANCE PUBLIQUE HOPITAUX DE PARIS ASSISTANCE PUBLIQUE HOPITAUX DE PARIS Organization address address: 3 AVENUE VICTORIA city: PARIS postcode: 75000 website: http://www.aphp.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	participant	216˙236.00
9	ETHERNA IMMUNOTHERAPIES ETHERNA IMMUNOTHERAPIES Organization address address: GALILEILAAN 19 city: NIEL postcode: 2845 website: www.etherna.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (NIEL)	participant	215˙000.00
10	VRIJE UNIVERSITEIT BRUSSEL VRIJE UNIVERSITEIT BRUSSEL Organization address address: PLEINLAAN 2 city: BRUSSEL postcode: 1050 website: www.vub.ac.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (BRUSSEL)	participant	198˙360.00
11	ASPHALION SL ASPHALION SL Organization address address: CALLE TARRAGONA, NUMEROS 151-157, PLANTA 10, BLOQU city: BARCELONA postcode: 8014 website: www.asphalion.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (BARCELONA)	participant	175˙000.00
12	EUROPEAN AIDS TREATMENT GROUP EV EUROPEAN AIDS TREATMENT GROUP EV Organization address address: METTMANNER STRASSE 24-26 city: DUSSELDORF postcode: 40233 website: www.eatg.org contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (DUSSELDORF)	participant	150˙000.00
13	UNIVERSIDAD COMPLUTENSE DE MADRID UNIVERSIDAD COMPLUTENSE DE MADRID Organization address address: AVENIDA DE SENECA 2 city: MADRID postcode: 28040 website: http://www.ucm.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (MADRID)	participant	128˙750.00
14	AELIX THERAPEUTICS SL AELIX THERAPEUTICS SL Organization address address: CALLE BALDIRI REIXAC, 4-8 city: BARCELONA postcode: 8028 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (BARCELONA)	participant	5˙242.00
15	Simon Fraser University Simon Fraser University Organization address address: UNIVERSITY DRIVE 8888 city: BURNABY postcode: V5A 1S6 website: http://www.sfu.ca contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CA (BURNABY)	participant	0.00

Map

Project objective

The main goal of HIVACAR proposal is to change the current paradigm of HIV treatment by obtaining a functional cure for HIV (i.e., control of viral load to levels below the threshold of 50 copies/ml and maintenance of high CD4 T-cell count after discontinuation of antiretroviral therapy) thanks to effectively targeting residual virus replication and viral reservoirs. In order to do so, the planned novel strategy is to successfully combine immune-based therapies, including therapeutic vaccines and broadly neutralizing antibodies with latency reversing agents, in a proof-of-concept phase IIa clinical trial. HIVACAR project will lead to a reduction of the actual costs related to HIV treatment and management and of the social public health as well as an improvement in the patients’ quality of life. HIVACAR project has been conceived under the framework of responsible research and innovation, so patients and other stakeholders will have a key role from the inception of the project until obtaining the results. Patients will be perfectly aware of how this therapy has been conceived and the real impact and change in their actual quality of life, as well as how the clinical trial has been designed and the consequences of participating in it. In addition, patients (and the general population) will tailor the project and its results dissemination and communication. This patient engagement will not be limited to the clinical trial but also to the rest of the activities of the project, so patients and the general society will be aware of how the research is developed and can include the patients’ point of view in the research activities. In addition, the socio-economic and psycho-social impact of the new treatment will be also analysed so overwhelming data on the benefits and impact of the new treatment will be obtained and shown to all the stakeholders.

Deliverables

List of deliverables.
Intermediate report on dissemination activities	Documents, reports	2020-02-19 17:35:24
Targeted communication tools	Documents, reports	2020-02-19 17:35:24
Final Briefing Document sent to EMA to request Scientific Advice containing information on the quality, nonclinical and clinical development program	Documents, reports	2020-02-19 17:35:24
Data Management Plan	Documents, reports	2020-02-19 17:35:24
Communication plan	Other	2020-02-19 17:35:24
HIVACAR Phase I/IIa clinical trial protocol	Documents, reports	2020-02-19 17:35:24

Take a look to the deliverables list in detail: detailed list of HIVACAR deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2019	Beatriz Perdiguero, Cristina SÃ¡nchez-Corzo, Carlos Oscar S. Sorzano, Lidia Saiz, Pilar Mediavilla, Mariano Esteban, Carmen Elena GÃ³mez A Novel MVA-Based HIV Vaccine Candidate (MVA-gp145-GPN) Co-Expressing Clade C Membrane-Bound Trimeric gp145 Env and Gag-Induced Virus-Like Particles (VLPs) Triggered Broad and Multifunctional HIV-1-Specific T Cell and Antibody Responses published pages: 160, ISSN: 1999-4915, DOI: 10.3390/v11020160	Viruses 11(2)	2020-02-19
2018	Beatriz Perdiguero; Suresh C. Raman; Cristina SÃ¡nchez-Corzo; Carlos Oscar S. Sorzano; JosÃ© RamÃ³n Valverde; Mariano Esteban; Carmen Elena GÃ³mez Potent HIV-1-Specific CD8 T Cell Responses Induced in Mice after Priming with a Multiepitopic DNA-TMEP and Boosting with the HIV Vaccine MVA-B published pages: 424, ISSN: 1999-4915, DOI: 10.3390/v10080424	Viruses 10(8)	2020-02-19

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The information about "HIVACAR" are provided by the European Opendata Portal: CORDIS opendata.