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3DQuant

Understanding long-range transcriptional regulation in the context of the 3D genome organization

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 3DQuant project word cloud

Explore the words cloud of the 3DQuant project. It provides you a very rough idea of what is the project "3DQuant" about.

stem    promoter    single    temporal    techniques    shown    chromosome    genetic    modulate    unknown    correlated    cell    topologically    mediated    promoters    sub    capture    action    loops    communication    measured    establishment    distances    self    expression    megabase    cells    3c    underlying    space    linked    close    mammalian    gene    structure    conformation    cognate    spatial    organization    manner    environment    transcriptional    modulates    contributes    enhancers    tads    view    modulation    suggests    relationship    folded    metazoans    enhancer    genes    regulation    associating    proximity    architecture    mouse    partitioning    unprecedented    mechanisms    patterns    quantitatively    physical    chromatin    isolated    live    outputs    mechanism    biophysical    engineering    technologies    partitioned    dimensional    measuring    chromosomes    embryonic    imaging    influences    quantitative    regulatory    generate    engineered    unravel    transcription    3d    interactions    domains    precisely    pairs    mobilized    genome    genomic   

Project "3DQuant" data sheet

The following table provides information about the project.

Coordinator
FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH FONDATION 

Organization address
address: MAULBEERSTRASSE 66
city: BASEL
postcode: 4058
website: www.fmi.ch

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 175˙419 €
 EC max contribution 175˙419 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-03-01   to  2019-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH FONDATION CH (BASEL) coordinator 175˙419.00

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 Project objective

Enhancers are regulatory elements that control the spatial and temporal expression of genes in metazoans. Enhancers are able to modulate transcription of a target gene from large genomic distances, as a result of the formation of chromatin loops that bring them in close spatial proximity to cognate promoters. The manner how specific patterns of enhancer-promoter physical interactions are established is linked to how chromosomes are folded in the three-dimensional (3D) space. Recent studies based on chromosome conformation capture (3C) have shown that mammalian chromosomes are partitioned into self-associating sub-megabase domains called Topologically Associating Domains (TADs). Genetic evidence suggests that 3D chromatin organization within and across TADs contributes to the establishment and partitioning of enhancers-promoters physical communication. Yet it is still unknown by which biophysical mechanisms chromosome architecture modulates enhancer action, and thus transcription. The goal of this proposal is to determine the quantitative relationship between 3D chromatin architecture and enhancer-promoter activity to unravel the mechanism of long-range transcriptional modulation mediated by enhancers. Addressing this goal requires a system where transcriptional outputs can be measured precisely and quantitatively, and correlated with 3D distances. To this aim, we will use state-of-the art genome engineering techniques to generate mouse embryonic stem cells with engineered enhancer-promoter pairs in an isolated chromatin environment, where a selected enhancer can be mobilized at different distances from its cognate promoter. We will use this system to quantitatively assess how 3D chromatin structure influences enhancer action by measuring transcription and promoter-enhancer interactions using 3C-based technologies, single-cell methods and live-cell imaging. This will lead to an unprecedented view of the mechanisms underlying long-range transcriptional regulation.

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