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PALAEO-ENEO SIGNED

Genomic and proteomic analysis of Palaeolithic, Neolithic and Bronze Age humans from Central-Southern Italy

Total Cost €

EC-Contrib. €

Partnership

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PALAEO-ENEO project word cloud

Explore the words cloud of the PALAEO-ENEO project. It provides you a very rough idea of what is the project "PALAEO-ENEO" about.

proteomic oral humans central omics modern migration southern outstanding population prehistoric communities landscape calculus neolithic microbiome consequence gatherers until integrate individuals west archaeological italy agricultural base structure metagenomic data cardial host culture taxonomic metabolic profiling groups gained peopling limited palaeolithic events genome asian day samples gatherer skeletal south similarly spectrometry interactions reconstructing heath ancestry steppe metaproteomic few hunter bronze characterised reconstruct genomic demographic mass dental initial preliminary plaque richest lost characterisation disease eurasians east personal genetic achievable screening transition human horizon mineralised migratory anatomically age ancient functions neolithisation

Project "PALAEO-ENEO" data sheet

The following table provides information about the project.

Coordinator	KOBENHAVNS UNIVERSITET Organization address address: NORREGADE 10 city: KOBENHAVN postcode: 1165 website: www.ku.dk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Denmark [DK]
Total cost	200˙194 €
EC max contribution	200˙194 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2016
Funding Scheme	MSCA-IF-EF-ST
Starting year	2017
Duration (year-month-day)	from 2017-11-01 to 2019-10-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	KOBENHAVNS UNIVERSITET KOBENHAVNS UNIVERSITET Organization address address: NORREGADE 10 city: KOBENHAVN postcode: 1165 website: www.ku.dk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (KOBENHAVN)	coordinator	200˙194.00

Map

Project objective

This project aims at reconstructing the ancestry and oral disease of Palaeolithic, Neolithic and Bronze Age anatomically modern humans from Central-Southern Italy, using genome-wide profiling and mass spectrometry-based proteomic analysis of skeletal remains and mineralised dental plaque (archaeological dental calculus). In Europe, the transition from hunter-gatherer to agricultural communities (Neolithisation) and the Bronze Age migration into Central Europe from the Asian steppe were the most important demographic events since the initial peopling by anatomically modern humans. However, until now, no Palaeolithic and only a few of Neolithic and Bronze age individuals from South Europe have been characterised for genomic analysis. As a consequence, the genetic base of outstanding peopling and migratory processes in prehistoric Europe, such as: (a) the East-West population structure among European hunter-gatherers, and (b) the Neolithic Southern European horizon known as the Cardial culture, still need to be fully understood. Similarly, metagenomic analysis of Palaeolithic and Neolithic dental calculus has been limited to preliminary screening of a limited number of samples, with no associated metaproteomic analysis. What taxonomic groups and metabolic functions were lost or gained with Neolithisation? How this affected oral heath? The genomic characterisation of Palaeolithic, Neolithic and Bronze Age humans from Southern Europe will be integrated with a metagenomic and metaproteomic analysis of dental calculus to produce the richest possible personal “-omics” profiling so far achievable for ancient humans. The two main research objectives are: 1. Integrate Palaeolithic, Neolithic and Bronze Age human genomic data from Central-Southern Italy within the genomic landscape available for all ancient and present-day West Eurasians, and 2. Reconstruct the oral microbiome, and its metabolic interactions with the host, before and after Neolithisation.

Publications

List of publications.
year	authors and title	journal	last update
2018	Marica Baldoni, Gabriele Scorrano, Angelo Gismondi, Alessia Dâ€™Agostino, Michelle Alexander, Luca Gaspari, Fabrizio Vallelonga, Antonella Canini, Olga Rickards, Cristina MartÃnez-Labarga Who were the miners of Allumiere? A multidisciplinary approach to reconstruct the osteobiography of an Italian worker community published pages: e0205362, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0205362	PLOS ONE 13/10	2020-04-09

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