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NeMatrix
Nematode-based screening technology for next-generation drug discovery
Total Cost €
0EC-Contrib. €
0Partnership
0Views
0NeMatrix project word cloud
Explore the words cloud of the NeMatrix project. It provides you a very rough idea of what is the project "NeMatrix" about.
definitely
mammals
maintenance
elegans
tests
expose
microscopic
animal
interesting
time
techniques
fill
microcompartments
clinical
distribute
replacing
completely
big
screening
actual
startup
generation
roundworms
proving
microfluidic
replacement
refinement
manual
protocols
operations
phenotypes
starting
popular
company
automated
observation
envisioned
species
caenorhabditis
separate
lacking
models
drug
platform
suspension
device
paving
monitor
gently
roundworm
prototype
feed
size
multiple
organism
context
creation
pharmaceutical
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suitable
organisms
rely
worm
culture
hinders
population
proposes
worms
biomedical
handling
examples
model
technologies
reproducibility
close
store
discovery
nematrix
throughput
framework
concentration
alternative
flies
first
standards
industries
technological
gap
named
nematodes
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food
industrial
concentrations
Project "NeMatrix" data sheet
The following table provides information about the project.
| Coordinator |
ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
Organization address contact info |
| Coordinator Country | Switzerland [CH] |
| Total cost | 150˙000 € |
| EC max contribution | 150˙000 € (100%) |
| Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
| Code Call | ERC-2016-PoC |
| Funding Scheme | ERC-POC |
| Starting year | 2017 |
| Duration (year-month-day) | from 2017-06-01 to 2018-11-30 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE | CH (LAUSANNE) | coordinator | 150˙000.00 |
Map
Project objective
Alternative model organisms, such as worms or flies, are getting increasingly popular in the drug discovery field, since they are proving to be suitable for replacing mammals for several aspects of the screening tests in the pre-clinical phase. In this context, one of the most interesting models is a roundworm species, named Caenorhabditis elegans. Its microscopic size, however, hinders its actual use in the field, since the protocols for its maintenance and study still completely rely on manual handling/observation techniques, definitely lacking any reproducibility and throughput standards. The NeMatrix project proposes to fill this technological gap, by developing a microfluidic platform for fully automated culture and analysis of C. elegans –and, more in general, roundworms-, tailored for drug screening applications. Specifically, starting from a simple worm suspension, our envisioned prototype will employ a set of microfluidic-based automated operations to: (i) gently distribute nematodes within separate microcompartments; (ii) feed them at desired food rate, time and concentration; (iii) expose them to drug tests at desired rate, time and drug concentrations; (iv) continuously monitor multiple phenotypes over the whole worm population in the device; (v) provide real-time data analysis and store/exploit results in a “big data” approach. This project would provide one of the first examples of next-generation technologies for whole-organism drug screening, with the potential of paving the way for the widespread use of worms and other alternative model organisms for the replacement, reduction and refinement of animal testing in biomedical research and pharmaceutical industries. The project will be held in close collaboration with key industrial partners in the field, in the framework of a planned startup company, which currently is on the way of creation.
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The information about "NEMATRIX" are provided by the European Opendata Portal: CORDIS opendata.
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